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公开(公告)号：US20110183991A1
公开(公告)日：2011-07-28
申请号：US13063947
申请日：2009-07-31
IPC分类号： A61K31/496 , C07D403/06 , A61P13/00 , C07D401/06 , A61P1/00 , A61P9/12 , A61P25/28 , A61P25/18 , A61P25/00 , A61P25/24 , A61P25/06 , A61P25/22
CPC分类号： A61K31/495 , A61K31/496 , A61K31/506 , A61K31/515
摘要： The present invention relates to compounds having pharmacological activity towards the 5-HT7 receptor, especially as agonists, identified by using a pharmacophore and a descriptor's profile filter as well as to pharmaceutical compositions comprising them. These compounds are useful in therapy in particular for the treatment and or prophylaxis of a disease in which 5-HT7 is involved, such as CNS disorders.
摘要翻译： 本发明涉及对5-HT7受体具有药理活性的化合物，特别是作为通过使用药效团和描述符轮廓过滤器鉴定的激动剂以及包含它们的药物组合物。 这些化合物特别用于治疗和/或预防其中涉及5-HT7的疾病，例如CNS疾病。
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12.发明申请SULFONAMIDE SUBSTITUTED PYRAZOLINE COMPOUNDS, THEIR PREPARATION AND USE AS CB1 MODULATORS 失效磺酰胺取代的吡咯啉化合物，其制备和用作CB1调节剂公开(公告)号：US20100184772A1
公开(公告)日：2010-07-22
申请号：US12445260
申请日：2007-10-10
IPC分类号： C07D231/06 , A61K31/415 , A61K31/4178 , C07D403/12 , C07D409/12 , A61K31/4155 , A61K31/428 , C07D417/12 , C07D405/12 , C07D413/12 , A61K31/422 , A61K31/513 , C07D401/12 , A61K31/4709 , A61K31/4439 , A61K31/4245 , A61K31/433 , A61K31/427 , A61K31/4725 , A61K31/498 , C07D513/04 , A61K31/429 , A61P5/00 , A61P9/00 , A61P11/00 , A61P25/00 , A61P37/00 , A61P15/00 , A61P1/00 , A61P35/00 , A61P19/00 , A61P3/00
CPC分类号： C07D231/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代吡唑啉化合物，其制备方法，包含这些化合物的药物及其制备用于治疗人和动物的药物的用途。
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13.发明申请Use of Compounds Binding to the Sigma Receptor for the Treatment of Metabolic Syndrome 审中-公开使用与Sigma受体结合用于治疗代谢综合征的化合物公开(公告)号：US20090181976A1
公开(公告)日：2009-07-16
申请号：US12224254
申请日：2007-02-28
IPC分类号： A61K31/495 , A61P3/10
CPC分类号： A61K31/00
摘要： The present invention refers to the use of compounds binding to the sigma receptor for the treatment of metabolic syndrome.
摘要翻译： 本发明涉及结合σ受体的化合物用于治疗代谢综合征的用途。
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公开(公告)号：US20170112829A1
公开(公告)日：2017-04-27
申请号：US15402867
申请日：2017-01-10
申请人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
发明人： José Manuel Baeyens-Cabrera , Helmut H. Buschmann , José-Miguel Vela-Hernandez , Daniel Zamanillo-Castanedo , Francisco Rafael Nieto-López
IPC分类号： A61K31/495
CPC分类号： A61K31/495 , A61K31/137 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/451 , A61K31/4515 , A61K31/454 , A61K31/46 , A61K31/5415
摘要： The present invention refers to the use of compounds binding to the sigma receptor for the treatment or prevention of neuropathic pain resulting from chemotherapy.
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15.发明授权Heterocyclyl-substituted-tetrahydro-naphthalen-amine derivatives, their preparation and use as medicaments 失效杂环取代 - 四氢 - 萘胺衍生物，其制备和用途作为药物公开(公告)号：US08236845B2
公开(公告)日：2012-08-07
申请号：US12593464
申请日：2008-03-28
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07D213/38 , C07D261/08 , C07D307/52 , C07D333/20
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘胺化合物及其组合物，其制备方法以及所述化合物用于治疗或预防人或动物各种疾病的用途。
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16.发明申请公开(公告)号：US20100197717A1
公开(公告)日：2010-08-05
申请号：US12451717
申请日：2008-05-27
申请人： Luz Romero-Alonso , Daniel Zamanillo-Castanedo , José-Miguel Vela-Hernandez , Helmut H. Buschmann
发明人： Luz Romero-Alonso , Daniel Zamanillo-Castanedo , José-Miguel Vela-Hernandez , Helmut H. Buschmann
IPC分类号： A61K31/485 , A61P25/00
CPC分类号： A61K45/06 , A61K31/415 , A61K31/485 , A61K2300/00
摘要： The present invention refers to a combination of a 5HT7 receptor ligand and an opioid receptor ligand, especially of a 5HT7 receptor agonist and an opioid receptor agonist, a medicament comprising this combination, or the use of this combination for the treatment of the symptoms of pain, the prevention or the prophylaxis of the symptoms of pain.
摘要翻译： 本发明涉及5HT7受体配体和阿片受体配体，特别是5HT7受体激动剂和阿片受体激动剂的组合，包含该组合的药物，或该组合用于治疗疼痛症状的组合 ，预防或预防疼痛症状。
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17.发明申请Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments 审中-公开杂环取代的 - 乙基氨基 - 苯基衍生物，它们的制备和用作药物公开(公告)号：US20100152252A1
公开(公告)日：2010-06-17
申请号：US12520463
申请日：2007-12-21
IPC分类号： A61K31/415 , C07D231/12 , C07C211/27 , C07C217/56 , C07D261/08 , C07D213/64 , A61K31/137 , A61K31/42 , A61K31/4418 , A61P25/00 , A61P25/06 , A61P25/22 , A61P9/12 , A61P1/00 , A61P29/00 , A61P13/00
CPC分类号： C07D231/12 , C07C211/27 , C07C211/29 , C07C217/60 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-ethylamino-phenyl compounds of general formula (I), wherein K-L-M-N, Z and R1, R2, R3, R4 are as described in the claims methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基取代的 - 乙基氨基 - 苯基化合物，其中KLMN，Z和R1，R2，R3，R4如权利要求的制备方法所述，包含这些化合物的药物以及 它们用于制备用于治疗人或动物的药物的用途。
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