摘要:
The invention relates to a process for the preparation of 1-(3-chlorophenyl)-4-methyl-7,8-dimethoxy-5 H-2,3-benzodiazepine of formula (I) ##STR1## in high purity and in a quality suitable for pharmaceutical purposes. According to the invention the reaction of 1 mole of 2-acetonyl-3'-chloro-4,5-dimethoxybenzophenone of formula (II) ##STR2## with 3-7 moles of hydrazine hydrate in an organic solvent or in a mixture of organic solvents at a temperature between 15.degree. C. and 85.degree. C. is carried out in the absence of air oxygen, optionally in the presence of water. The crude product is then recrystallized from an aliphatic alcohol containing 1 to 5 carbon atom(s).
摘要:
The invention relates to new substituted dihydropyridine derivatives of the general formula (I), ##STR1## wherein R.sup.1 and R.sup.6 are as defined herein after, the racemic and optically active variants as well as mixtures thereof, furthermore the acid addition salts of these compounds, pharmaceutical compositions containing the same and a process for the preparation thereof.The compounds of the general formula (I) can be advantageously applied for the treatment of pathologically severe hypertensions, their toxicity is low and they possess an advantageous therapeutic index.
摘要:
The invention relates to new peptide-aldehydes and a process for the preparation thereof, furthermore to pharmaceutical compositions containing the same.According to a feature of the present invention there are provided new peptide-aldehyde derivatives corresponding to the general formula (I) ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1-6 alkyl group,R.sub.2 stands for C.sub.1-6 alkyl group, furthermore R.sub.1 and R.sub.2 are linked to the amino group of the Xxx alpha-amino acid,Xxx represents a D-phenylalanine residue or a D-alpha-amino acid group having in the side chain a C.sub.1-4 alkyl group,Pro stands for L-proline residue,Yyy stands for L-, D- or DL-arginine residue andA represents an acid residue.The new peptide-aldehyde derivatives of the invention possess valuable anticoagulant activity.
摘要:
The invention relates to a process for the reduction of sodium hydroxide losses of the Bayer-cycle by modified causticization of red mud which comprisessubjecting an optionally previously concentrated red mud slurry led off from the red mud washing line by ramification and containing a liquid phase which has a concentration of 5-40 g. caustic Na.sub.2 0/1. caustification by adjusting the lime content expressed as CaO through addition of lime or lime milk to 1-3.2 moles per mole Al.sub.2 O.sub.3, preferably to 2-2.5 moles per mole Al.sub.2 O.sub.3, related to the total Al.sub.2 O.sub.3 content of the slurry;stirring the slurry for 0.3-5 hours at a temperature of 70.degree.-110.degree. C., preferably at 80.degree.-100.degree. C.;adding to the slurry 3-4 moles, preferably 3.2-3.4 moles, of soda related to 1 mole of the originally dissolved Al.sub.2 O.sub.3, and continuing the stirring for 1-4 hours at 80.degree.-100.degree. C., preferably at a temperature of 90.degree.-95.degree. C.;if necessary causticizing the excess of soda by adding lime or lime milk by methods known per se;if desired concentrating the slurry thus obtained and re-introducing the liquid phase thereof to the red mud washing unit which corresponds to the sodium hydroxide content thereof;and re-entering the slurry to the red mud washing line.The advantages of the process of the present invention are as follows: the sodium hydroxide losses of different origin of Bayer-type alumina production are recovered by a single operation step, the process is simple, requires no expensive equipment and is economical.
摘要翻译:本发明涉及通过红泥的改性苛化来降低拜耳 - 循环的氢氧化钠损失的方法,该方法包括将由红泥浆清洗线引出的任选预先浓缩的红泥浆经分散和含有液相 浓度为5-40g。 苛性钠Na20 / 1。 通过将石灰或石灰乳添加为1-3.2摩尔/摩尔Al 2 O 3,优选为2-2.5摩尔/摩尔Al 2 O 3,通过调整CaO表示的石灰含量与浆料的总Al 2 O 3含量相关; 在70-110℃,优选在80℃-100℃下搅拌该浆料0.3-5小时。 向浆料中加入3-4摩尔,优选3.2-3.4摩尔与1摩尔原始溶解的Al 2 O 3有关的苏打,并在80℃-100℃下,优选在 90°-95℃。 如果需要,通过本身已知的方法加入石灰或石灰乳来苛化苏打水; 如果需要浓缩由此获得的浆料并将其液相再引入对应于其氢氧化钠含量的红泥洗涤单元; 并将浆料重新进入红泥清洗线。 本发明方法的优点如下:通过单一操作步骤回收拜耳式氧化铝生产不同来源的氢氧化钠损失,工艺简单,不需要昂贵的设备,而且经济。
摘要:
A linear overpressured thin layer chromatographic apparatus comprises a base plate 3 supporting a sorbent layer 1 over which a membrane 4 is filled. The membrane 4 is externally pressurized by a fluid medium 10. A transparent cover plate 5 is fitted over the membrane 4, and there are sealed inlets 6, 7 passing through the cover plate 5 for the introduction of the mobile phase and the samples.
摘要:
The method of the invention is advantageously applicable to realize a multistage chemical process during which liquid clarifiers suitable for the purification of water and sewage, furthermore, fine-disperse pulverulent solid products utilizable as pait pigments and fillers may be recovered. Each final product of the multistage chemical processes is a useful material, so the whole technology is waste free.
摘要:
Novel 6-amino-5.alpha.,19-cycloandrostane derivatives of formula I and their pharmaceutically acceptable addition salts ##STR1## wherein X denotes any of the groups of the formula =CH(OR), =CO or =C=N-OR.sub.1,Y denotes any of the groups of the formula =CO, =CH(OR.sub.1), =C=N-OR.sub.1, =C(OR.sub.1)-C.tbd.CH or ##STR2## wherein R denotes a hydrogen atom, a C.sub.1-4 alkyl group or a C.sub.2-5 acyl group, andR.sub.1 denotes a hydrogen atom, a straight-chained or branched C.sub.1-5 alkyl group, a straight-chained or branched C.sub.1-5 hydroxyalkyl group, a C.sub.3-8 cycloalkyl group, an allyl group, or a benzyl group, andR.sub.3 has the same meaning as R.sub.2 but if R.sub.2 is a sec. or tert. alkyl group or an alicyclic group, then R.sub.3 can only be a hydrogen atom; and if R.sub.2 is a benzyl group then R.sub.3 can only be a hydrogen atom or a primary alkyl group, furtherR.sub.2 and R.sub.3 may denote together with the adjcacent nitrogen atom a piperidine, a morpholine, or an N-methylpiperazine group. These compounds have exhibited an aldosterone-antagonistic effect on rats.
摘要翻译:式I的新型6-氨基-5α,19-环戊二烯衍生物及其药学上可接受的加成盐(I)其中X表示式= CH(OR),= CO或= C = N -OR1,Y表示式= CO,= CH(OR1),= C = N-OR1,= C(OR1)-C3ONDCH或者其中R表示氢原子,C1 -4-烷基或C 2-5酰基,R 1表示氢原子,直链或支链C 1-5烷基,直链或支链C 1-5羟基烷基,C 3-8环烷基, 烯丙基或苄基,R3与R2具有相同的含义,但如果R2为秒。 或叔。 烷基或脂环基,那么R 3只能是氢原子; 并且如果R 2是苄基,那么R 3只能是氢原子或伯烷基,R 2和R 3可以与相邻的氮原子一起表示哌啶,吗啉或N-甲基哌嗪基。 这些化合物对大鼠表现出醛固酮拮抗作用。
摘要:
This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'--CH(OH)--CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties.
摘要:
The invention relates to the new 1-(3-chlorophenyl)-4-hydroxymethyl-7,8-dimethoxy-5H-2,3-benzodiazepine of formula (I) ##STR1## and pharmaceutically acceptable acid addition salts thereof, furthermore to a process for preparing these compounds.The compounds according to the invention possess valuable anxiolytic, antiaggressive and antidepressant effects and have at the same time favorable acute toxicity values, so they can be used to advantage in therapy.
摘要:
According to the process the grains are led to the surface or ducts of a rotary element farther in than the flange of the rotary element, thus the coarse grains are led to the flange of the rotary element in a counterflow to the sizing medium. In a housing on an impeller deflecting elements are arranged, the carrier medium and the mixture of material to be sized are fed into the housing by medium inlet tubes, and led out by coarse and fine fraction outlet tubes or nozzles, and one inlet disc is arranged above the impeller so that they form an annular assorting space which is divided by deflecting elements into segments, and a passage connected to the inlet tube of the sizing medium is formed between the mantle of the inlet disc and the inner wall of the housing at its upper end, where ducts leading into the assorting space are arranged in the inlet disc farther in than its flange, and which are connected to the carrier medium inlet tube.