公开(公告)号：US20160114323A1

公开(公告)日：2016-04-28

申请号：US14922696

申请日：2015-10-26

Applicant: Arizona Board of Regents on behalf of Arizona State University

Inventor： Rhett Martineau ,  Jeff Houkal ,  Shih-Hui Chao ,  Weimin Gao ,  Shufang Ci ,  Deirdre Meldrum

IPC: B01L3/00

CPC classification number: B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L7/52 ,  B01L2200/0605 ,  B01L2200/0642 ,  B01L2200/0647 ,  B01L2200/0684 ,  B01L2300/044 ,  B01L2300/0636 ,  B01L2300/0681 ,  B01L2300/0803 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/161 ,  B01L2400/049 ,  B01L2400/0683

Abstract: The invention relates to microfluidic devices and array disks for “one-pot” isolated chemical reactions. The array disks comprise a plurality of sectors in which each sector comprises one microfluidic device. The microfluidic devices comprise a fluid delivery channel and an array of wells wherein the fluid delivery channel delivery fluid into the wells in a serpentine arrangement. In some embodiments, the fluid delivery channel is directly above the array of wells. In other embodiments, the fluid delivery channel is offset from the array of wells so that side channels branching from the fluid delivery channel delivers fluid into the wells. The well of the microfluidic device comprises a gas-permeable membrane that forms the floor, well, or at least a portion of the floor or wall of the well. In preferred embodiments, the well is cylindrical.

Abstract translation: 本发明涉及用于“一锅”分离的化学反应的微流体装置和阵列盘。 阵列盘包括多个扇区，其中每个扇区包括一个微流体装置。 微流体装置包括流体输送通道和孔阵列，其中流体输送通道以蛇形结构输送到孔中。 在一些实施例中，流体输送通道直接在孔阵列的上方。 在其他实施例中，流体输送通道偏离孔阵列，使得从流体输送通道分支的侧通道将流体输送到孔中。 微流体装置的井包括形成地板，井或井的地板或墙壁的至少一部分的透气膜。 在优选实施例中，井是圆柱形的。