公开(公告)号：US20200276438A1

公开(公告)日：2020-09-03

申请号：US16877554

申请日：2020-05-19

Applicant: Battelle Memorial Institute

Inventor： Chad E. Bouton ,  Gaurav Sharma ,  Andrew Sweeney ,  Amy M. Heintz ,  Stephanie Kute ,  Nicholas Annetta ,  Thomas D. Haubert ,  Steven M. Risser ,  Jeffrey Friend ,  John Bartholomew ,  Rachel Thurston ,  C. Alexander Morrow ,  George Brand ,  Jeffrey Ellis ,  Matthew Mowrer ,  Raymond Zaborski

IPC: A61N1/05 ,  A61B5/0488 ,  A61N1/04 ,  A61B5/00 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/11

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

公开(公告)号：US20180154140A1

公开(公告)日：2018-06-07

申请号：US15578816

申请日：2016-06-02

Applicant: Battelle Memorial Institute

Inventor： Chad E. Bouton ,  Gaurav Sharma ,  Andrew Sweeney ,  Amy M. Heintz ,  Stephanie Kute ,  Nicholas Annetta ,  Thomas D. Haubert ,  Steven M. Risser ,  Jeffrey Friend ,  John Bartholomew ,  Rachel Thurston ,  C. Alexander Morrow ,  George Brand ,  Jeffrey Ellis ,  Matthew Mowrer ,  Raymond Zaborski

IPC: A61N1/05 ,  A61B5/0478 ,  A61B5/00 ,  A61B5/0488 ,  A61B5/11 ,  A61N1/04

CPC classification number: A61N1/0556 ,  A61B5/0478 ,  A61B5/0482 ,  A61B5/0488 ,  A61B5/11 ,  A61B5/1127 ,  A61B5/4836 ,  A61B5/686 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/048 ,  A61N1/0484 ,  A61N1/36003

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

公开(公告)号：US20240271072A1

公开(公告)日：2024-08-15

申请号：US18625358

申请日：2024-04-03

Applicant: Battelle Memorial Institute

Inventor： Charles L. Desanti ,  Ryan W. Daly ,  David Charles Seibert, JR. ,  Patrick Norris ,  John Bartholomew ,  Sherry K. Blight

IPC: C12M3/06 ,  C12M1/00 ,  C12M1/34

CPC classification number: C12M23/16 ,  C12M23/34 ,  C12M23/40 ,  C12M27/18 ,  C12M29/10 ,  C12M41/46

Abstract: A biological culture unit comprises a chamber body and a valve plate. The chamber body has defined therein a growth chamber and an aliquot chamber. The valve plate is disposed on the top surface of the chamber body and is movable to define selectable configurations of the biological culture unit for: (1) loading the growth chamber; (3) transferring an aliquot from the growth chamber to the aliquot chamber via a path defined within the biological culture unit in the transfer position; and (4) extracting the aliquot from the aliquot chamber. The selectable positions may further include (2) a growth position, and (5) a termination position for putting a termination agent into the growth and aliquot chambers. The valve plate may further include a neutralizer port that is aligned with the aliquot chamber in the loading position, for loading a neutralizing agent into the aliquot chamber.

公开(公告)号：US11534605B2

公开(公告)日：2022-12-27

申请号：US16877554

申请日：2020-05-19

Applicant: Battelle Memorial Institute

Inventor： Chad E. Bouton ,  Gaurav Sharma ,  Andrew Sweeney ,  Amy M. Heintz ,  Stephanie Kute ,  Nicholas Annetta ,  Thomas D. Haubert ,  Steven M. Risser ,  Jeffrey Friend ,  John Bartholomew ,  Rachel Thurston ,  Alexander C. Morrow ,  George Brand ,  Jeffrey Ellis ,  Matthew Mowrer ,  Raymond Zaborski

IPC: A61N1/05 ,  A61N1/04 ,  A61B5/00 ,  A61B5/11 ,  A61B5/291 ,  A61B5/375 ,  A61B5/389 ,  A61N1/36

Abstract: The present disclosure relates to neuromuscular stimulation and sensing cuffs. The neuromuscular stimulation cuff has at least two fingers and a plurality of electrodes disposed on each finger. More generally, the neuromuscular stimulation cuff includes an outer, reusable component and an inner, disposable component. One or more electrodes are housed within the reusable component. The neuromuscular stimulation cuff may be produced by providing an insulating substrate layer, forming a conductive circuit on the substrate layer to form a conductive circuit layer, adhering a cover layer onto the conductive circuit layer to form a flexible circuit, and cutting at least one flexible finger from the flexible circuit. The neuromuscular stimulation cuff employs a flexible multi-electrode design which allows for reanimation of complex muscle movements in a patient, including individual finger movement.

公开(公告)号：US10695564B2

公开(公告)日：2020-06-30

申请号：US15612894

申请日：2017-06-02

Applicant: Battelle Memorial Institute

Inventor： John Bartholomew ,  Jeffrey Friend

IPC: A61N1/04 ,  A61N1/36 ,  B29C35/02 ,  A61N1/02 ,  A61N1/08 ,  B29L7/00 ,  B29L31/00

Abstract: A flexible sheet for neurostimulation is described having a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.

公开(公告)号：US20180001086A1

公开(公告)日：2018-01-04

申请号：US15612894

申请日：2017-06-02

Applicant: Battelle Memorial Institute

Inventor： John Bartholomew ,  Jeffrey Friend

IPC: A61N1/36 ,  B29C35/02 ,  A61N1/04 ,  B29L31/00 ,  A61N1/02 ,  B29L7/00 ,  A61N1/08

CPC classification number: A61N1/36003 ,  A61N1/025 ,  A61N1/0452 ,  A61N1/0456 ,  A61N1/0476 ,  A61N1/0484 ,  A61N1/0492 ,  A61N1/08 ,  A61N1/36031 ,  A61N1/36034 ,  B29C35/02 ,  B29K2995/0005 ,  B29L2007/002 ,  B29L2031/753

Abstract: A flexible sheet for neurostimulation is described having a flexible non-conductive substrate matrix in which electrodes are embedded along a lower surface. Electrically conductive wires extend from the electrodes through the flexible substrate to another exterior surface of the substrate. Methods of making the flexible sheet and making a device using the flexible sheet are also disclosed.