公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.

公开(公告)号：US20220016275A1

公开(公告)日：2022-01-20

申请号：US17292479

申请日：2019-11-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Simona GHIANI ,  Alessandro MAIOCCHI ,  Ivan HAWALA

IPC: A61K51/08 ,  C07K7/64 ,  A61P35/00

Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.

公开(公告)号：US20210395832A1

公开(公告)日：2021-12-23

申请号：US17292748

申请日：2019-11-08

Applicant: BRACCO IMAGING S.P.A.

Inventor： Andrea FERRARIS ,  Erika REITANO ,  Alessandro MAIOCCHI

IPC: C12Q1/6886

Abstract: Disclosed are gene signatures and methods for predicting the recurrence of prostate cancer in prostatectomized subjects. Other objectives of the invention are assay devices and kits for determining the expression levels of specific gene sets correlated to prostate cancer recurrence.