公开(公告)号：US20190275180A1

公开(公告)日：2019-09-12

申请号：US16363193

申请日：2019-03-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Mathilde H. LERCHE ,  Pernille Rose JENSEN ,  Magnus KARLSSON ,  Roberta NAPOLITANO ,  Claudia CABELLA ,  Luigi MIRAGOLI ,  Sonia COLOMBO SERRA ,  Fabio TEDOLDI

IPC: A61K51/04 ,  A61B5/00 ,  A61K49/10 ,  C07C69/007 ,  C07B59/00 ,  A61B5/055

Abstract: 1-13C-1,1-Bis(acetoxy(methyl))-2,2′-cyclopropane of formula (I): The compound can be hyperpolarized and used as a contrast agent in 13C Magnetic Resonance diagnostic technique (13C-MR) for the diagnosis of tumor.

公开(公告)号：US20170252464A1

公开(公告)日：2017-09-07

申请号：US15500024

申请日：2015-07-22

Applicant: BRACCO IMAGING S.P.A. ,  UNIVERSITA DI PAVIA

Inventor： Elena ELISEI ,  Attilio CESARO ,  Marta FILIBIAN ,  Pietro CARRETTA ,  Sonia COLOMBO SERRA ,  Alessandro MAIOCCHI ,  Fabio TEDOLDI

IPC: A61K49/10 ,  A61K49/18

CPC classification number: A61K49/10 ,  A61K49/18

Abstract: A method for preparing a sample for dynamic nuclear polarization which comprises submitting a solid substrate to a milling process in the presence of a polarizing agent at a temperature lower than the glass-transition temperature (Tg) of said substrate. Preferably said substrate may be in crystalline form.

公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.