公开(公告)号：US20160228583A1

公开(公告)日：2016-08-11

申请号：US15130160

申请日：2016-04-15

Applicant: BRACCO IMAGING S.p.A.

Inventor： Pier Lucio ANELLI ,  Pierfrancesco MOROSINI ,  Silvia CERAGIOLI ,  Fulvio UGGERI ,  Luciano LATTUADA ,  Roberta FRETTA ,  Aurelia FERRIGATO

IPC: A61K49/18 ,  C07C213/10 ,  B29C67/24 ,  C07C227/40

CPC classification number: A61K49/1887 ,  A61K9/0019 ,  B29C67/24 ,  C07C213/10 ,  C07C227/38 ,  C07C227/40 ,  Y10T428/2982 ,  C07C229/22

Abstract: The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.

Abstract translation: 本发明公开了一种以固体形式制备钆酸二甲酚络合物的方法。 特别地，所述固体形式通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地得到。 本发明对于工业规模是特别有利的，因为固体形式可以通过使用水作为溶剂，其是无毒溶剂，易于处理并且基本上不需要麻烦的健康或安全预防措施来获得。

公开(公告)号：US20220370646A1

公开(公告)日：2022-11-24

申请号：US17771168

申请日：2020-10-20

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Mariangela BOCCALON ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Alessandro MAIOCCHI ,  Roberta MAZZON ,  Fabio TEDOLDI ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.

公开(公告)号：US20250109094A1

公开(公告)日：2025-04-03

申请号：US18860494

申请日：2023-04-28

Applicant: BRACCO IMAGING S.P.A.

Inventor： Zsolt BARANYAI ,  Nicol GUIDOLIN ,  Federica LAZZARI ,  Fulvio UGGERI

IPC: C07C235/48

Abstract: The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I2 and an oxide or a salt of an element of group 11 of the periodic table.

公开(公告)号：US20240271295A1

公开(公告)日：2024-08-15

申请号：US18694306

申请日：2022-09-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Luciano LATTUADA ,  Camilla CAVALLOTTI ,  Giovanni Battista GIOVENZANA ,  Fulvio UGGERI ,  Alessandro MINGUZZI ,  Alberto VERTOVA ,  Letizia SORTI ,  Carlo MORELLI

IPC: C25B3/27 ,  C07C231/12 ,  C07C237/46 ,  C25B3/07 ,  C25B3/09 ,  C25B3/11 ,  C25B15/08

CPC classification number: C25B3/27 ,  C07C231/12 ,  C07C237/46 ,  C25B3/07 ,  C25B3/09 ,  C25B3/11 ,  C25B15/081 ,  C25B15/083 ,  C25B15/087

Abstract: The invention is related to a process for preparing a iodinating X-rays contrast agent. More specifically, it relates to a process for the preparation of N,N′-bis-(2,3-dihydroxypropyl)-5-hydroxy-2,4,6-triiodo-1,3-benzenedicarboxaniide (I) by electrochemical iodination of N,N′-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide (II) with molecular iodine (I2) which is in situ electrochemically generated from a source of iodide ions (I−). The iodide ions (I−) are obtained by the dissolution of hydrogen iodide (HI) or an alkali metal iodide in the reaction medium or produced during the reaction of N,N′-(2,3-dihydroxypropyl)-5-hydroxy-1,3-benzenedicarboxamide with I2. The invention also relates to the use of the intermediate compound of formula (I), obtained through the above electrochemical iodination of compound (II), in the preparation of N,N′-bis[2,3-dihydroxypropyl]-5(hydroxyacetyl)methylamino]-2,4,6-triiodo-1,3-benzenedicarboxamide (iomeprol).

公开(公告)号：US20190209713A1

公开(公告)日：2019-07-11

申请号：US16256749

申请日：2019-01-24

Applicant: BRACCO IMAGING S.P.A.

Inventor： Silvio AIME ,  Daniela DELLI CASTELLI ,  Franco FEDELI ,  Dario Livio LONGO ,  Enzo TERRENO ,  Fulvio UGGERI

IPC: A61K49/10

Abstract: The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.

公开(公告)号：US20170340755A1

公开(公告)日：2017-11-30

申请号：US15535937

申请日：2015-12-18

Applicant: BRACCO IMAGING S.P.A.

Inventor： Alessandro MAIOCCHI ,  Chiara BRIOSCHI ,  Fulvio UGGERI ,  Giovanni VALBUSA

IPC: A61K49/00 ,  A61B10/00 ,  A61B5/08 ,  A61B5/00

Abstract: The present invention relates to the use of a NIR fluorescent probe comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety in the fluorescence- guided surgery of pathologic regions and to an optical imaging method that comprises using this fluorescent probe for the identification and demarcation of tumor margins during the surgical resection.