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公开(公告)号：US20250109094A1
公开(公告)日：2025-04-03
申请号：US18860494
申请日：2023-04-28
Applicant: BRACCO IMAGING S.P.A.
Inventor： Zsolt BARANYAI , Nicol GUIDOLIN , Federica LAZZARI , Fulvio UGGERI
IPC: C07C235/48
Abstract: The invention relates to a process for the preparation of a 2,4,6-triiodo-phenol derivative of formula (II), which is useful as an intermediate for the synthesis of conventional X-ray contrast agents, said process comprising the tri-iodination of the correspondent phenol derivative of said 2,4,6-triiodo-phenol derivative by means of an iodinating system comprising I2 and an oxide or a salt of an element of group 11 of the periodic table.
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公开(公告)号：US20210196840A1
公开(公告)日：2021-07-01
申请号：US17199122
申请日：2021-03-11
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta NAPOLITANO , Luciano LATTUADA , Zsolt BARANYAI , Nicole GUIDOLIN , Giuseppe MARAZZI
Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic glutaric acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
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公开(公告)号：US20180036436A1
公开(公告)日：2018-02-08
申请号：US15551612
申请日：2016-02-25
Applicant: BRACCO IMAGING S.P.A.
Inventor： Zsolt BARANYAI , Zoltán GARDA , Simona GHIANI , Ferenc Krisztián KÁLMÁN , László KRUSPER , Alessandro MAIOCCHI , Gyula TIRCSÓ , Imre TOTH
IPC: A61K49/10 , C07D295/185 , C07D211/42 , C07D211/46 , C07D211/48 , C07D207/34 , C07D211/62 , C07D211/16 , C07D295/192 , C07D491/107 , C07D221/22 , C07D471/08 , G01N33/58 , G01N24/08 , A61B5/055 , C07D207/325
CPC classification number: A61K49/106 , A61B5/055 , A61B2503/40 , A61K49/103 , C07C237/06 , C07D207/325 , C07D207/34 , C07D211/16 , C07D211/42 , C07D211/46 , C07D211/48 , C07D211/62 , C07D221/22 , C07D295/185 , C07D295/192 , C07D401/12 , C07D403/12 , C07D471/08 , C07D491/107 , G01N24/08 , G01N33/58
Abstract: The present invention relates to novel substituted ethylenediaminetetraacetic acid bisamide derivatives, their complexes with Mn(II) ion and the use thereof as contrast agents for Magnetic Resonance Imaging (MRI) analysis.
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Patent Agency Ranking
公开(公告)号：US20240366802A1
公开(公告)日：2024-11-07
申请号：US18734341
申请日：2024-06-05
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta NAPOLITANO , Luciano LATTUADA , Zsolt BARANYAI , Nicole GUIDOLIN , Giuseppe MARAZZI
IPC: A61K49/10 , C07D471/08 , C07F5/00
Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
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公开(公告)号：US20200376145A1
公开(公告)日：2020-12-03
申请号：US16766619
申请日：2019-08-06
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta NAPOLITANO , Luciano LATTUADA , Zsolt BARANYAI , Nicole GUIDOLIN , Giuseppe MARAZZI
Abstract: The present invention relates to the RRR/SSS pair of enantiomers of the of Gd(PCTA-tris-glutamic acid), the single enantiomers of the pair, the pharmaceutically acceptable salts thereof, their amide derivatives, and compositions comprising at least 50% of these compounds.
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公开(公告)号：US20250163007A1
公开(公告)日：2025-05-22
申请号：US18871962
申请日：2023-07-28
Applicant: BRACCO IMAGING S.P.A.
Inventor： Mauro BOTTA , Lorenzo TEI , Fabio CARNIATO , Zsolt BARANYAI , Mariangela BOCCALON
IPC: C07D255/02 , A61K49/10
Abstract: The invention relates to the novel compounds of formula (I) as well as ions, stereoisomers, tautomers, hydrates, solvates, pharmaceutically acceptable salts thereof, or mixtures of the same. The compounds of formula (I) are ligands that are able to chelate Fe(III) ions, thereby generating Fe(III) complexes, which are particularly suitable in diagnostic imaging, for example as contrast agents for magnetic resonance imaging (MRI), due to their high relaxivity, thermodynamic stability, kinetic inertness and redox stability.
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公开(公告)号：US20220370646A1
公开(公告)日：2022-11-24
申请号：US17771168
申请日：2020-10-20
Applicant: BRACCO IMAGING S.P.A.
Inventor： Zsolt BARANYAI , Mariangela BOCCALON , Federica BUONSANTI , Federico CRIVELLIN , Alessandro MAIOCCHI , Roberta MAZZON , Fabio TEDOLDI , Fulvio UGGERI
IPC: A61K49/10
Abstract: The present invention relates to pharmaceutical compositions comprising an gadolinium-complex and a saturated macrocyclic tetraamine that find application in diagnostic imaging as diagnostic agents, in particular as contrast agents having improved tolerability, specifically in Magnetic Resonance Imaging (MRI), and to their preparation.
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公开(公告)号：US20220016275A1
公开(公告)日：2022-01-20
申请号：US17292479
申请日：2019-11-12
Applicant: BRACCO IMAGING S.P.A.
Inventor： Zsolt BARANYAI , Simona GHIANI , Alessandro MAIOCCHI , Ivan HAWALA
Abstract: A chelating compound of formula (I) or a pharmaceutically acceptable salt thereof and its complexes with metals or radioisotopes thereof. The invention further relates to the preparation of such ligand and complexes as well as to their use as diagnostic or therapeutic agents.
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