Patent search ap:("BRISTOL-MYERS SQUIBB COMPANY") AND inv:"John F. Kadow" Page 2

11.

发明申请
BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C 审中-公开

公开(公告)号：US20180030016A1

公开(公告)日：2018-02-01

申请号：US15551002

申请日：2016-02-17

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang , Zhiwei Yin , Zhongxing Zhang , John F. Kadow

IPC: C07D307/82 , C07D405/12 , C07D405/04

CPC classification number: C07D307/82 , C07D307/84 , C07D405/04 , C07D405/12

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

12.

发明申请
6H-FURO[2,3-E]INDOLE COMPOUNDS FOR THE TREATMENT OF HEPATITIS C 审中-公开

公开(公告)号：US20170174696A1

公开(公告)日：2017-06-22

申请号：US15127054

申请日：2015-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang , Zhongxing Zhang , John F. Kadow

IPC: C07D491/048 , C07B59/00

CPC classification number: C07D491/048 , C07B59/002 , C07B2200/05

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

13.

发明申请
SUBSTITUTED 2-PHENYL (AZA)BENZOFURAN COMPOUNDS FOR THE TREATMENT OF HEPATITIS C 审中-公开

公开(公告)号：US20170121340A1

公开(公告)日：2017-05-04

申请号：US15317541

申请日：2015-06-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao WANG , Zhongxing Zhang , Kyle E. Parcella , Kyle J. Eastman , John F. Kadow

IPC: C07D491/048 , C07D307/84

CPC classification number: C07D491/048 , C07D307/84 , C07D405/12 , C07D491/04

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

14.

发明申请
SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES 审中-公开

公开(公告)号：US20160075703A1

公开(公告)日：2016-03-17

申请号：US14878270

申请日：2015-10-08

Applicant: Bristol-Myers Squibb Company

Inventor： TAO WANG , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

IPC: C07D471/04 , C07D491/048

CPC classification number: C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives having the Formula I: wherein Q is These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

15.

发明申请
SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES 审中-公开
Title translation: 取代的氮杂双环哌嗪衍生物

公开(公告)号：US20150259342A1

公开(公告)日：2015-09-17

申请号：US14725298

申请日：2015-05-29

Applicant: Bristol-Myers Squibb Company

Inventor： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

IPC: C07D471/04 , C07D491/048

CPC classification number: C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives having the Formula I: wherein Q is These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。特别地，本发明涉及具有式I的亚硝基二氧乙酰基哌嗪衍生物：其中Q是这些化合物具有独特的抗病毒活性，无论是单独使用还是与其它抗病毒剂，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。

16.

发明申请
TRICYCLIC AMIDINE DERIVATIVES AS HIV ATTACHMENT INHIBITORS 有权
Title translation: 作为艾滋病毒附着抑制剂的三甲基胺衍生物

公开(公告)号：US20150210676A1

公开(公告)日：2015-07-30

申请号：US14419568

申请日：2013-08-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang , Zhongxing Zhang , Zhiwei Yin , John F. Kadow , Nicholas A. Meanwell

IPC: C07D413/12 , A61K45/06 , A61K31/5513 , C07D471/04 , A61K31/553 , C07D403/12

CPC classification number: C07D413/12 , A61K31/5513 , A61K31/553 , A61K45/06 , C07D403/12 , C07D471/04

Abstract: Compounds of Formula I, including pharmaceutically acceptable salts thereof: (F) wherein A is selected from the group consisting of: (F) and; (F) and wherein Z is: (F) are useful as HIV attachment inhibitors.

Abstract translation: 式I化合物，包括其药学上可接受的盐：（F）其中A选自：（F）和（F），其中Z是：（F）可用作HIV附着抑制剂。

17.

发明申请
Hepatitis C Virus Inhibitors 审中-公开
Title translation: 丙型肝炎病毒抑制剂

公开(公告)号：US20140205564A1

公开(公告)日：2014-07-24

申请号：US14221774

申请日：2014-03-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Jeffrey Lee Romine , Denis R. St. Laurent , Makonen Belema , Lawrence B. Snyder , Lawrence G. Hamann , John F. Kadow , Jayne Kapur , Andrew C. Good , Omar D. Lopez , Rico Lavoie , John A. Bender

IPC: C07D403/14 , A61K45/06 , A61K38/21 , A61K31/7056 , A61K31/4725 , C07D405/14 , A61K31/454 , C07D413/14 , A61K31/422 , A61K31/4184 , A61K38/20

CPC classification number: C07D403/14 , A61K31/4184 , A61K31/422 , A61K31/454 , A61K31/4725 , A61K31/7056 , A61K38/2013 , A61K38/204 , A61K38/208 , A61K38/21 , A61K38/212 , A61K45/06 , C07D405/14 , C07D413/14

Abstract: The present disclosure relates to compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.

Abstract translation: 本公开涉及用于治疗丙型肝炎病毒（HCV）感染的化合物，组合物和方法。还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。

18.

发明申请
PHARMACEUTICAL FORMULATIONS OF SUBSTITUTED AZAINDOLEOXOACETIC PIPERAZINE DERIVATIVES WITH PROTEASE INHIBITORS 审中-公开
Title translation: 替代酰基氨基哌啶衍生物与蛋白酶抑制剂的药物制剂

公开(公告)号：US20140135342A1

公开(公告)日：2014-05-15

申请号：US14156718

申请日：2014-01-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang , Zhongxing Zhang , Nicholas A. Meanwell , John F. Kadow , Zhiwei Yin , Qiufen May Xue , Alicia Regueiro-Ren , John D. Matiskella , Yasutsugu Ueda

IPC: C07D471/04 , A61K45/06 , A61K31/496

CPC classification number: C07D471/04 , A61K31/496 , A61K45/06 , C07D491/048

Abstract: This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with azaindoleoxoacetyl piperazine derivatives. These compounds possess unique antiviral activity, whether used alone or in combination with other antivirals, antiinfectives, immunomodulators or HIV entry inhibitors. More particularly, the present invention relates to the treatment of HIV and AIDS.

Abstract translation: 本发明提供具有药物和生物影响性质的化合物，其药物组合物和使用方法。特别地，本发明涉及氮杂吲哚乙酰基哌嗪衍生物。这些化合物具有独特的抗病毒活性，无论是单独使用还是与其他抗病毒药，抗感染剂，免疫调节剂或HIV进入抑制剂组合使用。更具体地说，本发明涉及艾滋病毒和艾滋病的治疗。

19.

发明申请
Novel Compounds for the Treatment of Hepatitis C 有权
Title translation: 用于治疗丙型肝炎的新型化合物

公开(公告)号：US20130203775A1

公开(公告)日：2013-08-08

申请号：US13755971

申请日：2013-01-31

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun Yeung , John F. Kadow

IPC: C07D405/14

CPC classification number: C07D405/14 , C07D405/04

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。