公开(公告)号：US09249152B2

公开(公告)日：2016-02-02

申请号：US14663497

申请日：2015-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Kyle J. Eastman ,  Zhongxing Zhang ,  Kyle E. Parcella ,  Zhiwei Yin ,  John F. Kadow

IPC: C07D491/048 ,  C07D491/04

CPC classification number: C07D491/048 ,  C07D491/04

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

Abstract translation: 阐述了式I化合物，包括它们的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者：

公开(公告)号：US20150266886A1

公开(公告)日：2015-09-24

申请号：US14663497

申请日：2015-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Kyle J. Eastman ,  Zhongxing Zhang ,  Kyle E. Parcella ,  Zhiwei Yin ,  John F. Kadow

IPC: C07D491/048

CPC classification number: C07D491/048 ,  C07D491/04

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

Abstract translation: 阐述了式I化合物，包括它们的盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者：

公开(公告)号：US10214534B2

公开(公告)日：2019-02-26

申请号：US15317541

申请日：2015-06-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Zhongxing Zhang ,  Kyle E. Parcella ,  Kyle J. Eastman ,  John F. Kadow

IPC: C07D491/048 ,  C07D405/12 ,  C07D491/04 ,  C07D307/84

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

公开(公告)号：US08962651B2

公开(公告)日：2015-02-24

申请号：US14204292

申请日：2014-03-11

Applicant: Bristol-Myers Squibb Company

Inventor： Kyle J. Eastman ,  Kyle E. Parcella ,  John F. Kadow

IPC: A61K31/44 ,  C07D471/02 ,  C07D491/02 ,  C07D498/02 ,  C07D491/048 ,  C07D491/04

CPC classification number: C07D491/048 ,  C07D491/04

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US20170121340A1

公开(公告)日：2017-05-04

申请号：US15317541

申请日：2015-06-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao WANG ,  Zhongxing Zhang ,  Kyle E. Parcella ,  Kyle J. Eastman ,  John F. Kadow

IPC: C07D491/048 ,  C07D307/84

CPC classification number: C07D491/048 ,  C07D307/84 ,  C07D405/12 ,  C07D491/04

Abstract: Compounds of Formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV:

公开(公告)号：US20170107202A1

公开(公告)日：2017-04-20

申请号：US15290167

申请日：2016-10-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： KAP-SUN YEUNG ,  Timothy P. Connolly ,  David B. Frennesson ,  Katharine A. Grant-Young ,  Piyasena Hewawasam ,  David R. Langley ,  Zhaoxing Meng ,  Eric Mull ,  Kyle E. Parcella ,  Mark George Saulnier ,  Li-Qiang Sun ,  Alan Xiangdong Wang ,  Ningning Xu ,  Juliang Zhu ,  Paul Michael Scola

IPC: C07D401/14 ,  A61K31/5377 ,  C07D213/85 ,  A61K31/4439 ,  C07D401/12 ,  A61K31/4545 ,  A61K31/44 ,  C07D471/04 ,  C07D405/14 ,  A61K31/454 ,  C07D403/12 ,  A61K31/4025 ,  A61K31/496 ,  C07D205/04 ,  A61K31/397 ,  A61K31/4427 ,  A61K31/4453 ,  C07D211/22 ,  A61K31/40 ,  C07D207/14 ,  C07D207/12 ,  A61K31/138 ,  C07C215/20 ,  C07D413/14 ,  C07D213/82 ,  C07D491/08 ,  C07D417/14 ,  A61K31/541 ,  C07D471/08 ,  C07D405/12 ,  A61K31/135 ,  C07D213/80 ,  C07D207/16 ,  C07D265/30 ,  A61K31/5375 ,  A61K31/166 ,  C07C235/46 ,  C07D417/12 ,  A61K45/06

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US20140275154A1

公开(公告)日：2014-09-18

申请号：US14204292

申请日：2014-03-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kyle J. Eastman ,  Kyle E. Parcella ,  John F. Kadow

IPC: C07D491/048

CPC classification number: C07D491/048 ,  C07D491/04

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US08722688B2

公开(公告)日：2014-05-13

申请号：US13798286

申请日：2013-03-13

Applicant: Bristol-Myers Squibb Company

Inventor： Kap-Sun Yeung ,  Kyle E. Parcella ,  John A. Bender ,  Brett R. Beno ,  Katharine A. Grant-Young ,  Ying Han ,  Piyasena Hewawasam ,  John F. Kadow ,  Andrew Nickel

IPC: A61K31/506

CPC classification number: A61K31/506 ,  A61K45/06 ,  C07D307/84 ,  C07D405/04 ,  C07D405/10 ,  C07D405/12 ,  C07D407/12 ,  C07D409/12 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D453/00 ,  C07D491/10

Abstract: The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

Abstract translation: 本公开提供式I化合物，包括其盐，以及使用该化合物的组合物和方法。 该化合物具有抗丙型肝炎病毒（HCV）的活性，可用于治疗HCV感染者。

公开(公告)号：US10745382B2

公开(公告)日：2020-08-18

申请号：US15290167

申请日：2016-10-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Kap-Sun Yeung ,  Timothy P. Connolly ,  David B. Frennesson ,  Katharine A. Grant-Young ,  Piyasena Hewawasam ,  David R. Langley ,  Zhaoxing Meng ,  Eric Mull ,  Kyle E. Parcella ,  Mark George Saulnier ,  Li-Qiang Sun ,  Alan Xiangdong Wang ,  Ningning Xu ,  Juliang Zhu ,  Paul Michael Scola

IPC: C07D401/14 ,  C07D213/71 ,  C07D455/02 ,  A61K31/135 ,  A61K31/138 ,  A61K31/166 ,  A61K31/397 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4439 ,  A61K31/4453 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/5375 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07C215/20 ,  C07C235/46 ,  C07D205/04 ,  C07D207/12 ,  C07D207/14 ,  C07D207/16 ,  C07D211/22 ,  C07D213/80 ,  C07D213/82 ,  C07D213/85 ,  C07D265/30 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D491/08

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

公开(公告)号：US09957278B2

公开(公告)日：2018-05-01

申请号：US15500110

申请日：2015-08-04

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tao Wang ,  Kyle J. Eastman ,  Zhongxing Zhang ,  Kyle E. Parcella ,  John F. Kadow

IPC: C07D491/048 ,  A61K31/4355 ,  C07B59/00

CPC classification number: C07D491/048 ,  C07B59/002 ,  C07B2200/05

Abstract: Compounds of formula I, including their salts, as well as compositions and methods of using the compounds are set forth. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.