公开(公告)号：US09771411B2

公开(公告)日：2017-09-26

申请号：US14664290

申请日：2015-03-20

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Stuart Emanuel ,  Linda Engle ,  Ray Camphausen ,  Martin C. Wright ,  Ginger Chao Rakestraw ,  Marco Gottardis ,  Joan Carboni

IPC: A61K38/16 ,  A61K38/39 ,  C07K14/435 ,  C07K14/475 ,  C07K14/78 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  C07K14/705 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/39 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/475 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/34 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/30

Abstract: The present invention relates to bispecific molecules comprising an EGFR binding domain and a distinct IGFIR binding domain for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and vectors comprising the polynucleotides encoding the innovative proteins. Exemplary bispecific molecules include antibody-like protein dimers based on the tenth fibronectin type III domain.

公开(公告)号：US11344639B2

公开(公告)日：2022-05-31

申请号：US16305284

申请日：2017-05-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie Lafont ,  Daniel Cohen ,  David K. Leung

IPC: A61K51/08 ,  C07B59/00 ,  C07K16/28

Abstract: Provided herein are novel 10Fn3 domains which specifically bind to PD-L1, as well as imaging agents based on the same for diagnostics.

公开(公告)号：US10406251B2

公开(公告)日：2019-09-10

申请号：US15529260

申请日：2015-11-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Paul E. Morin ,  David Donnelly ,  Dasa Lipovsek ,  Jochem Gokemeijer ,  Maria N. Jure-Kunkel ,  David Fabrizio ,  Martin C. Wright ,  Douglas Dischino ,  Samuel J. Bonacorsi, Jr. ,  Ralph Adam Smith ,  Virginie Lafont ,  Daniel Cohen

IPC: A61K51/08 ,  C07K14/78 ,  G01N33/60 ,  G01N33/68 ,  G01N33/574

Abstract: Provided herein are novel polypeptides comprising fibronectin type III tenth (10Fn3) domains which specifically bind to Programmed Death Ligand-1 (PD-L1), as well as imaging agents based on the same for diagnostics.