公开(公告)号：US20160016961A1

公开(公告)日：2016-01-21

申请号：US14772152

申请日：2014-03-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Prashantha Gunaga ,  John Lloyd ,  Srinivasu Pothukanuri

IPC: C07D487/04 ,  A61K31/5025

CPC classification number: C07D487/04 ,  A61K31/5025

Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 该化合物可用作钾通道功能的抑制剂和治疗心律不齐，IKur相关疾病以及由离子通道功能介导的其它病症。

公开(公告)号：US20160009719A1

公开(公告)日：2016-01-14

申请号：US14772403

申请日：2014-03-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Prashantha Gunaga ,  John Lloyd ,  Srinivasu Pothukanuri

IPC: C07D487/04 ,  A61K31/53

CPC classification number: C07D487/04 ,  A61K31/53 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D413/04 ,  C07D413/14

Abstract: A compound of formula (I), wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 式（I）化合物，其中A，R 1，R 3和R 24在本文中描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。

公开(公告)号：USRE49700E1

公开(公告)日：2023-10-17

申请号：US17183286

申请日：2021-02-23

Applicant: Bristol-Myers Squibb Company

Inventor： Navnath Dnyanoba Yadav ,  Rajeev S. Bhide ,  Rajesh Onkardas Bora ,  Prashantha Gunaga ,  Manoranjan Panda ,  Eldon Scott Priestley ,  Jeremy Richter

IPC: C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

CPC classification number: C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D487/04

Abstract: Disclosed are compounds of Formula (I)




or a salt thereof,

wherein R1 is:





each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

公开(公告)号：US20200255407A1

公开(公告)日：2020-08-13

申请号：US16864825

申请日：2020-05-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D513/04 ,  C07D471/04 ,  C07D405/12 ,  C07D239/94 ,  A61K45/06 ,  A61K31/549 ,  A61K31/5377 ,  A61K31/517 ,  C07D417/14 ,  C07D417/12 ,  C07D413/14 ,  C07D407/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/12 ,  C07D239/95

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US20190144426A1

公开(公告)日：2019-05-16

申请号：US16243400

申请日：2019-01-09

Applicant: Bristol-Myers Squibb Company

Inventor： James A. Johnson ,  John Lloyd ,  Heather Finlay ,  James Neels ,  Naveen Kumar Dhondi ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  A61K31/5377 ,  C07D239/95 ,  C07D513/04 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  A61K31/517 ,  C07D417/14 ,  C07D417/12 ,  C07D413/14 ,  C07D407/12 ,  C07D403/12 ,  C07D403/04 ,  C07D401/12 ,  A61K31/549

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US10214511B2

公开(公告)日：2019-02-26

申请号：US15724566

申请日：2017-10-04

Applicant: Bristol-Myers Squibb Company

Inventor： John Lloyd ,  Heather Finlay ,  Prashantha Gunaga ,  Abhisek Banerjee ,  Ashokkumar Adisechan

IPC: C07D401/14 ,  C07D239/95 ,  C07D401/12 ,  C07D403/04 ,  C07D403/12 ,  C07D407/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/549 ,  A61K45/06 ,  C07D239/94 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04

Abstract: A compound of formula I wherein A, X, Y, Z, R1 and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US09458164B2

公开(公告)日：2016-10-04

申请号：US14772152

申请日：2014-03-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Prashantha Gunaga ,  John Lloyd ,  Srinivasu Pothukanuri

IPC: C07D487/04 ,  A61K31/5025

CPC classification number: C07D487/04 ,  A61K31/5025

Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

公开(公告)号：US09242966B2

公开(公告)日：2016-01-26

申请号：US14200063

申请日：2014-03-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Prashantha Gunaga ,  John Lloyd ,  Pothukanuri Srinivasu

IPC: C07D405/14 ,  C07D401/14 ,  C07D401/04 ,  C07D401/12 ,  C07D403/04 ,  A61K31/502 ,  A61K31/506

CPC classification number: C07D405/14 ,  A61K31/502 ,  A61K31/506 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04

Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment and prevention of arrhythmia, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 这些化合物可用作钾通道功能的抑制剂和治疗和预防心律失常，IKur相关疾病以及由离子通道功能介导的其它病症。

公开(公告)号：US09050345B2

公开(公告)日：2015-06-09

申请号：US14200055

申请日：2014-03-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Naveen Kumar Dhondi ,  Kavitha Govindrajulu ,  Prashantha Gunaga ,  John Lloyd ,  Pothukanuri Srinivasu

IPC: C07D487/04 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  A61K31/53 ,  A61P9/06 ,  A61P9/04 ,  C07D405/04 ,  C07D405/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  A61K31/5377 ,  C07D519/00

CPC classification number: A61K31/5377 ,  A61K31/53 ,  C07D487/04 ,  C07D519/00

Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 该化合物可用作钾通道功能的抑制剂和治疗心律不齐，维持正常窦性心律，IKur相关疾病以及由离子通道功能介导的其它病症。

公开(公告)号：US20140256719A1

公开(公告)日：2014-09-11

申请号：US14200055

申请日：2014-03-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heather Finlay ,  Ashok Kumar Adisechan ,  Naveen Kumar Dhondi ,  Kavitha Govindrajulu ,  Prashantha Gunaga ,  John Lloyd ,  Pothukanuri Srinivasu

IPC: A61K31/5377 ,  C07D487/04 ,  A61K31/53

CPC classification number: A61K31/5377 ,  A61K31/53 ,  C07D487/04 ,  C07D519/00

Abstract: A compound of formula (I) wherein A, R1, R3, and R24 are described herein. The compounds are useful as inhibitors of potassium channel function and in the treatment of arrhythmia, maintaining normal sinus rhythm, IKur-associated disorders, and other disorders mediated by ion channel function.

Abstract translation: 其中A，R1，R3和R24的式（I）化合物在此描述。 该化合物可用作钾通道功能的抑制剂和治疗心律不齐，维持正常窦性心律，IKur相关疾病以及由离子通道功能介导的其它病症。