公开(公告)号：US20210244711A1

公开(公告)日：2021-08-12

申请号：US17221859

申请日：2021-04-05

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： PETER TAI WAH CHENG ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: A61K31/4192 ,  C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/454 ,  C07D401/04

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11008317B2

公开(公告)日：2021-05-18

申请号：US16083958

申请日：2017-03-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ellen K. Kick ,  Joanne M. Smallheer ,  Scott A. Shaw ,  Benjamin P. Vokits ,  Andrew K. Dilger ,  Charles G. Clark ,  Meriah Neissel Valente ,  Sutjano Jusuf ,  Nicholas R. Wurtz

IPC: C07D471/04 ,  C07D519/00

Abstract: The present invention provides compounds of Formula (I); wherein the substituents are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

公开(公告)号：US09920075B2

公开(公告)日：2018-03-20

申请号：US15510168

申请日：2015-09-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nicholas R. Wurtz ,  Andrew Quoc Viet ,  Scott A. Shaw ,  Benjamin P. Vokits ,  Ellen K. Kick ,  Meriah Neissel Valente ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty ,  Sutjano Jusuf

IPC: A61K31/519 ,  C07D519/00 ,  C07D471/04 ,  C07D487/04 ,  A61K31/437

CPC classification number: C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): wherein A and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US20170247396A1

公开(公告)日：2017-08-31

申请号：US15510168

申请日：2015-09-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Nicholas R. Wurtz ,  Andrew Quoc Viet ,  Scott A. Shaw ,  Benjamin P. Vokits ,  Ellen K. Kick ,  Meriah Neissel Valente ,  Andrew K. Dilger ,  Kumar Balashanmuga Pabbisetty ,  Sutjano Jusuf

IPC: C07D519/00 ,  C07D487/04 ,  C07D471/04

CPC classification number: C07D519/00 ,  A61K31/437 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04

Abstract: The present invention provides compounds of Formula (I): wherein A and R1 are each as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments.

公开(公告)号：US20220249443A1

公开(公告)日：2022-08-11

申请号：US17718760

申请日：2022-04-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: A61K31/4192 ,  C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/454 ,  C07D401/04

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US11267800B2

公开(公告)日：2022-03-08

申请号：US16772825

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Ying Wang ,  Peter Tai Wah Cheng ,  Jun Shi ,  Shiwei Tao ,  James R. Corte ,  Tianan Fang ,  Jun Li ,  Lawrence J. Kennedy ,  Robert F. Kaltenbach, III ,  Sutjano Jusuf

IPC: C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D491/052

Abstract: The present invention provides compounds of Formula (I): Formula (I) or a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US10576062B2

公开(公告)日：2020-03-03

申请号：US16038739

申请日：2018-07-18

Applicant: Bristol-Myers Squibb Company

Inventor： Peter Tai Wah Cheng ,  Robert F. Kaltenbach, III ,  Jun Li ,  Jun Shi ,  Yan Shi ,  Shiwei Tao ,  Hao Zhang ,  Suresh Dhanusu ,  Kumaravel Selvakumar ,  Ramesh Babu Reddigunta ,  Steven J. Walker ,  Lawrence J. Kennedy ,  James R. Corte ,  Tianan Fang ,  Sutjano Jusuf

IPC: C07D401/14 ,  C07D249/06 ,  A61K31/27 ,  A61K31/4192 ,  A61K31/454 ,  C07D401/04 ,  A61K31/41 ,  C07C62/10

Abstract: The present invention provides compounds of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein all the variables are as defined herein. These compounds are selective LPA receptor inhibitors.

公开(公告)号：US20190177340A1

公开(公告)日：2019-06-13

申请号：US16099010

申请日：2017-06-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joanne M. Smallheer ,  Ellen K. Kick ,  Meriah Neissel Valente ,  Carol Hui Hu ,  Oz Scott Halpern ,  Sutjano Jusuf

IPC: C07D519/00

CPC classification number: C07D519/00 ,  A61P9/10

Abstract: The present invention provides compounds of Formula (I): wherein the substituents are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, and may be useful for for the treatment and/or prophylaxis of atherosclerosis, heart failure, chronic obstructive pulmonary disease (COPD), and related diseases.

公开(公告)号：US09938222B2

公开(公告)日：2018-04-10

申请号：US15509214

申请日：2015-09-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yan Shi ,  Peter T. W. Cheng ,  Ying Wang ,  Sutjano Jusuf ,  Shiwei Tao ,  Hao Zhang ,  Shung C. Wu ,  Jeffrey A. Robl

IPC: C07C62/34 ,  C07C59/64 ,  C07D307/79 ,  C07D277/30 ,  C07D213/55 ,  C07D231/12 ,  C07D213/65

CPC classification number: C07C62/34 ,  A61K31/192 ,  A61K31/343 ,  A61K31/415 ,  A61K31/426 ,  A61K31/44 ,  A61K31/4418 ,  C07C59/64 ,  C07C2601/02 ,  C07D207/323 ,  C07D213/55 ,  C07D213/65 ,  C07D231/12 ,  C07D277/30 ,  C07D277/593 ,  C07D307/79 ,  C07D307/82

Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, or a pharmaceutically acceptable salt thereof, wherein all of the variables are as defined herein. These compounds are GPR120 G protein-coupled receptor modulators which may be used as medicaments.