公开(公告)号：US20160068594A1

公开(公告)日：2016-03-10

申请号：US14947939

申请日：2015-11-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Benedicte Jardin

IPC: C07K16/18

CPC classification number: G01N33/721 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/531 ,  G01N33/582 ,  G01N33/723 ,  Y10T436/101666 ,  Y10T436/25125

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

Abstract translation: 各自的血红蛋白，其变体和糖基化形式在多重测定中单独测定，其允许校正测量的HbA1c水平以解释与样品中包含变体相关的糖基化变体和其它因素。 还提供了特别适合于多重测定的新抗体。

公开(公告)号：US20140073532A1

公开(公告)日：2014-03-13

申请号：US14081799

申请日：2013-11-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Benedicte Jardin

IPC: G01N33/72 ,  C07K16/18

CPC classification number: G01N33/721 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/531 ,  G01N33/582 ,  G01N33/723 ,  Y10T436/101666 ,  Y10T436/25125

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

Abstract translation: 各自的血红蛋白，其变体和糖基化形式在多重测定中单独测定，其允许校正测量的HbA1c水平以解释与样品中包含变体相关的糖基化变体和其它因素。 还提供了特别适合于多重测定的新抗体。

公开(公告)号：US20240248086A1

公开(公告)日：2024-07-25

申请号：US18437816

申请日：2024-02-09

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/571 ,  G01N33/543 ,  G01N33/92

CPC classification number: G01N33/571 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/92 ,  G01N2333/20 ,  G01N2405/04 ,  G01N2469/20

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US11913954B2

公开(公告)日：2024-02-27

申请号：US17170577

申请日：2021-02-08

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/53 ,  G01N33/571 ,  G01N33/543 ,  G01N33/92

CPC classification number: G01N33/571 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/92 ,  G01N2333/20 ,  G01N2405/04 ,  G01N2469/20

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US10324091B2

公开(公告)日：2019-06-18

申请号：US15701272

申请日：2017-09-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/53 ,  G01N33/571 ,  G01N33/543 ,  G01N33/92

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US10067135B2

公开(公告)日：2018-09-04

申请号：US15897040

申请日：2018-02-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: C12Q1/68 ,  C12Q1/70 ,  A61K39/00 ,  A61K38/00 ,  C07H21/04 ,  G01N33/576 ,  G01N33/543

CPC classification number: G01N33/5761 ,  G01N33/54326

Abstract: Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.

公开(公告)号：US09213034B2

公开(公告)日：2015-12-15

申请号：US14081799

申请日：2013-11-15

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Benedicte Jardin

IPC: C07K16/18 ,  G01N33/72 ,  G01N33/58

CPC classification number: G01N33/721 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/531 ,  G01N33/582 ,  G01N33/723 ,  Y10T436/101666 ,  Y10T436/25125

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

Abstract translation: 各自的血红蛋白，其变体和糖基化形式在多重测定中单独测定，其允许校正测量的HbA1c水平以解释与样品中包含变体相关的糖基化变体和其它因素。 还提供了特别适合于多重测定的新抗体。

公开(公告)号：US20140065634A1

公开(公告)日：2014-03-06

申请号：US14019150

申请日：2013-09-05

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  John Wesley Breneman, III

IPC: C12Q1/68

CPC classification number: C12Q1/6804 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/24 ,  G01N33/5308 ,  G01N33/564

Abstract: Provided herein are antibodies for determining the concentration of anti-dsDNA and anti-chromatin antibodies in biological samples.

Abstract translation: 本文提供了用于测定生物样品中抗dsDNA和抗染色质抗体浓度的抗体。

公开(公告)号：US10942182B2

公开(公告)日：2021-03-09

申请号：US16832608

申请日：2020-03-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/571 ,  G01N33/543 ,  G01N33/92

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US10921315B2

公开(公告)日：2021-02-16

申请号：US15617979

申请日：2017-06-08

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Yabin Lu ,  Urvee Desai ,  Daming Shan

IPC: G01N33/531 ,  G01N33/564 ,  C07K14/415 ,  G01N33/68 ,  C12N9/10

Abstract: Methods of diagnosing celiac disease in a subject are provided. In some embodiments, the method comprises contacting a sample of bodily fluid from the subject with an antigen comprising a recombinant or synthetic deamidated gliadin protein, wherein the deamidated gliadin protein comprises a hexamer of peptides each having the sequence of SEQ ID NO:1; and detecting an antibody from the sample that specifically binds to the antigen, thereby diagnosing celiac disease in the subject.