公开(公告)号：US20190265240A1

公开(公告)日：2019-08-29

申请号：US16405588

申请日：2019-05-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/571 ,  G01N33/92 ,  G01N33/543

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US20190018023A1

公开(公告)日：2019-01-17

申请号：US16145021

申请日：2018-09-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Benedicte Jardin

IPC: G01N33/72 ,  G01N33/531 ,  C07K16/18 ,  G01N33/58

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

公开(公告)号：US20180172687A1

公开(公告)日：2018-06-21

申请号：US15897040

申请日：2018-02-14

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/576 ,  G01N33/543

CPC classification number: G01N33/5761 ,  G01N33/54326

Abstract: Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.

公开(公告)号：US09927439B2

公开(公告)日：2018-03-27

申请号：US14261525

申请日：2014-04-25

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: C12Q1/68 ,  C12Q1/70 ,  A61K39/00 ,  A61K39/29 ,  C07K14/005 ,  G01N33/576 ,  G01N33/543

CPC classification number: G01N33/5761 ,  G01N33/54326

Abstract: Provided herein are multiplex assays for determining whether an individual is or has been infected with Hepatitis B virus, and the stage of infection or resolution. In addition, the multiplex system can discriminate between vaccinated subjects and subjects susceptible to Hepatitis B infection.

公开(公告)号：US11262366B2

公开(公告)日：2022-03-01

申请号：US16145021

申请日：2018-09-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Benedicte Jardin

IPC: G01N33/531 ,  C07K16/18 ,  G01N33/72 ,  G01N33/58

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

公开(公告)号：US20170370931A1

公开(公告)日：2017-12-28

申请号：US15701272

申请日：2017-09-11

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/571 ,  G01N33/543 ,  G01N33/92

CPC classification number: G01N33/571 ,  G01N33/543 ,  G01N33/54313 ,  G01N33/92 ,  G01N2333/20 ,  G01N2405/04 ,  G01N2469/20

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US20210156859A1

公开(公告)日：2021-05-27

申请号：US17170577

申请日：2021-02-08

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/571 ,  G01N33/543 ,  G01N33/92

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US20200225230A1

公开(公告)日：2020-07-16

申请号：US16832608

申请日：2020-03-27

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/571 ,  G01N33/543 ,  G01N33/92

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US10648981B2

公开(公告)日：2020-05-12

申请号：US16405588

申请日：2019-05-07

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Ravi Kaul ,  Weiming Zheng ,  Roger Walker

IPC: G01N33/53 ,  G01N33/571 ,  G01N33/543 ,  G01N33/92

Abstract: Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.

公开(公告)号：US09605060B2

公开(公告)日：2017-03-28

申请号：US14947939

申请日：2015-11-20

Applicant: Bio-Rad Laboratories, Inc.

Inventor： Roger Walker ,  Benedicte Jardin

IPC: C07K16/18 ,  G01N33/531 ,  G01N33/58 ,  G01N33/72

CPC classification number: G01N33/721 ,  C07K16/18 ,  C07K2317/34 ,  C07K2317/92 ,  G01N33/531 ,  G01N33/582 ,  G01N33/723 ,  Y10T436/101666 ,  Y10T436/25125

Abstract: Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of HbA1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.