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11.发明授权Apparatus and method for separating a volume of composite liquid into at least two components 有权将体积的复合液体分离成至少两个组分的装置和方法公开(公告)号：US07347932B2
公开(公告)日：2008-03-25
申请号：US10783831
申请日：2004-02-20
申请人： Brian M. Holmes , Peter Pihlstedt , Geert Van Waeg
发明人： Brian M. Holmes , Peter Pihlstedt , Geert Van Waeg
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B01D21/262 , B01D2221/10 , B04B5/0428 , B04B5/0442 , B04B13/00 , B04B2013/006
摘要： A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at at least one second transfer flow rate that is different from the at least one first transfer flow rate.
摘要翻译： 在与包含复合液体体积的分离袋配合的离心机中进行将复合液体的体积分离成至少第一成分和第二成分的方法。 分离袋连接到至少第一组分袋和第二组分袋。 旋转分离袋以离心复合液体的体积并引起至少第一和第二组分的沉降。 当至少第一和第二组分沉淀时，第一组分以至少一个第一转移流速转移到第一组分袋中。 当第一组分转移到第一组分袋中时，第二组分以不同于至少一个第一转移流速的至少一个第二转移流速转移到中间组分袋中。
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公开(公告)号：US07824355B2
公开(公告)日：2010-11-02
申请号：US12187988
申请日：2008-08-07
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
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公开(公告)号：US20090043237A1
公开(公告)日：2009-02-12
申请号：US12187988
申请日：2008-08-07
IPC分类号： A61M1/14
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
摘要翻译： 提出了用于血液处理的方法，装置和装置部件。 特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。 一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。 另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。 另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。
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14.发明申请Method and Apparatus for Separating A Composite Liquid Into At Least Two Components And For Determining The Yield Of At Least One Component 有权将复合液体分离成至少两种成分并确定至少一种成分的产率的方法和装置公开(公告)号：US20100026986A1
公开(公告)日：2010-02-04
申请号：US12494476
申请日：2009-06-30
申请人： Briden Ray Stanton , Geert Van Waeg
发明人： Briden Ray Stanton , Geert Van Waeg
CPC分类号： G01N33/491 , A61M1/0272 , A61M1/3696 , A61M2202/0427
摘要： Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal.
摘要翻译： 用于通过感测在从分离容器到收集容器的表达过程中分离的细胞组分或另一组分的移动以产生指示运动的信号并预测来自复合血液制品的选定细胞组分的产量的方法和装置 从信号中分离的细胞成分的产率。
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15.发明授权Method and apparatus for separating a composite liquid into at least two components and for determining the yield of at least one component 有权将复合液体分离成至少两种组分并确定至少一种组分的产率的方法和设备公开(公告)号：US08120760B2
公开(公告)日：2012-02-21
申请号：US12494476
申请日：2009-06-30
申请人： Briden Ray Stanton , Geert Van Waeg
发明人： Briden Ray Stanton , Geert Van Waeg
IPC分类号： G01N33/48
CPC分类号： G01N33/491 , A61M1/0272 , A61M1/3696 , A61M2202/0427
摘要： Method and Apparatus for predicting the yield of a selected cellular component from a composite blood product by sensing the movement of the separated cellular component or another component during expression from a separation container to a collection container to produce a signal indicative of the movement, and predicting the yield of the separated cellular component from the signal.
摘要翻译： 用于通过感测在从分离容器到收集容器的表达过程中分离的细胞组分或另一组分的移动以产生指示运动的信号并预测来自复合血液制品的选定细胞组分的产量的方法和装置 从信号中分离的细胞成分的产率。
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公开(公告)号：US07704454B1
公开(公告)日：2010-04-27
申请号：US10680950
申请日：2003-10-08
CPC分类号： A61M1/3693 , A61M1/304 , A61M1/3639 , A61M1/3656 , A61M1/3696
摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.
摘要翻译： 提出了用于血液处理的方法，装置和装置部件。 特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。 一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。 另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。 另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。
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17.发明授权Method and apparatus for controlling concentrations in vivos and in tubing systems 失效用于控制活体和管道系统中浓度的方法和装置
公开(公告)号：US5817042A
公开(公告)日：1998-10-06
申请号：US622642
申请日：1996-03-27
CPC分类号： A61M1/3672 , A61M1/303 , A61M1/30 , A61M1/34 , A61M1/3693
摘要： A method and apparatus for maximizing the total amount of blood processed during an apheresis procedure by optimizing the concentration of anticoagulant in a donor/patient and the associated extracorporeal tubing set is provided. A simplified model of anticoagulant accumulation in a donor/patient's body is used to calculate an optimal anticoagulant infusion rate profile to the donor/patient during a blood processing procedure. A maximum acceptable anticoagulant concentration in the donor/patient acts as an upper limit on the rate at which anticoagulant may be infused to the donor/patient using the optimized infusion rate profile. A minimum acceptable anticoagulant level acts as a lower limit in optimally controlling the anticoagulant concentration in the extracorporeal tubing set. Both the maximum acceptable anticoagulant level in the donor/patient and the minimum acceptable anticoagulant level in the extracorporeal tubing set may be customized for a specific donor/patient thereby allowing the optimized infusion rate profile and the extracorporeal tubing set anticoagulant concentration to be customized for the specific patient.
摘要翻译： 提供了一种通过优化供体/患者和相关体外管组中的抗凝血剂的浓度来最大化在分离术过程中处理的血液总量的方法和装置。 供体/患者体内的抗凝血剂积聚的简化模型用于在血液处理过程中计算给予者/患者的最佳抗凝血剂输注速率曲线。 供体/患者中最大可接受的抗凝血剂浓度作为使用优化的输注速率曲线将抗凝血剂注入供体/患者的速率的上限。 最小可接受的抗凝血剂水平作为最佳控制体外管组中抗凝血剂浓度的下限。 供体/患者中最大可接受的抗凝血剂水平和体外管组中最小可接受的抗凝血剂水平可以针对特定供体/患者定制，从而允许优化的输注速率曲线和体外管道凝固剂浓度定制为 具体病人。
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公开(公告)号：US07651474B2
公开(公告)日：2010-01-26
申请号：US10861199
申请日：2004-06-03
申请人： Geert Van Waeg , Bruce W. Gibbs , Marc Antoon , Laura Goodrich
发明人： Geert Van Waeg , Bruce W. Gibbs , Marc Antoon , Laura Goodrich
CPC分类号： A61M1/3693 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/30 , A61M1/303 , A61M1/308 , A61M1/3633 , A61M1/3692 , A61M1/3696 , A61M1/3698 , A61M2202/0429 , A61M2202/0439 , A61M2205/123 , A61M2202/0071
摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves filtering the separated red blood cells in a high hematocrit (high-crit) state prior to addition of storage solution thereto. Preferably, a storage solution is passed through the leukoreduction filter after the RBCs have been filtered therethrough. The red blood cell collection filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component, as described.
摘要翻译： 提供一种用于红血采集和过滤的方法和装置，其中红细胞收集组件与红细胞收集程序同时或之后提供白细胞减少过滤。 该方法优选包括在加入其中的储存溶液之前以高血细胞比容（高暴击）状态过滤分离的红细胞。 优选地，在通过其过滤RBC之后，使储存溶液通过白细胞减少过滤器。 红细胞收集过滤和储存组件优选地预先连接到血液成分分离一次性组件，包括例如离心机容器和用于从供体去除血液的除血/返回组件，将血液通过离心机容器 将血液分离成用于收集的组分并提供分离的红细胞组分的过滤，如所述。
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公开(公告)号：US20070255505A1
公开(公告)日：2007-11-01
申请号：US11727550
申请日：2007-03-27
申请人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt , Brian Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin
发明人： Niclas Hogberg , Emanuel Hallgren , Peter Pihlstedt , Brian Holmes , Lars Persson , Lars Strandberg , Geert Van Waeg , Frank Corbin
CPC分类号： B04B13/00 , A61M1/0209 , A61M1/0218 , A61M1/025 , A61M1/26 , A61M1/262 , A61M1/3633 , A61M1/3639 , A61M1/3641 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M2205/331 , B04B5/0428 , B04B5/0442 , B04B2005/045 , B04B2005/0478 , B04B2013/006
摘要： A system and method are used in connection with processing of blood components. The processing of blood components may involve centrifugal separation and/or filtering of the blood components. In some examples, at least some blood components are centrifugally separated in a chamber and then filtered via a filter rotating along with a centrifuge rotor, wherein the filter is located closer than the chamber to an axis of rotation of the rotor. The filter may include a porous filtration medium configured to filter leukocytes, platelets, and/or red blood cells. Some examples include a pressure sensor sensing pressure of pumped blood components. The sensed pressure may be used in connection with controlling the pumping of the blood products and/or in connection with determining the location of an interface associated with the blood products. Other uses of the sensed pressure are also possible.
摘要翻译： 与血液成分的处理有关的系统和方法。 血液成分的处理可能涉及血液成分的离心分离和/或过滤。 在一些实例中，至少一些血液成分在室中离心分离，然后通过与离心机转子一起旋转的过滤器过滤，其中过滤器位于离转子更靠近转动轴的位置。 过滤器可以包括被配置为过滤白细胞，血小板和/或红细胞的多孔过滤介质。 一些示例包括感测泵送的血液成分的压力的压力传感器。 感测到的压力可以与控制血液制品的泵送和/或与确定与血液制品相关联的界面的位置的结合一起使用。 感测压力的其他用途也是可能的。
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公开(公告)号：US6022306A
公开(公告)日：2000-02-08
申请号：US924787
申请日：1997-09-05
CPC分类号： B04B5/0442 , A61M1/3618 , A61M1/362 , A61M1/3693 , A61M1/3696 , B04B2005/0471
摘要： The instant invention relates to a method and the apparatus for collecting a hyperconcentrated platelet product. A fluid containing platelets and other particles flows into a fluid chamber at a flow rate. The flow rate of the fluid is selected to retain the majority of the platelets in the fluid chamber in a saturated bed. The platelets are collected from the fluid chamber without collecting the other particles to form a hyperconcentrated other particle reduced platelet product.
摘要翻译： 本发明涉及用于收集高浓度血小板产品的方法和装置。 含有血小板和其它颗粒的流体以流速流入流体室。 选择流体的流速以将大部分血小板保持在饱和床中的流体室中。 从流体腔室收集血小板而不收集其它颗粒以形成高浓度的其它颗粒还原血小板产物。
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