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    Method and apparatus for leukoreduction of red blood cells
    1.
    发明授权
    Method and apparatus for leukoreduction of red blood cells 有权
    红细胞白细胞减少的方法和装置

    公开(公告)号：US07651474B2

    公开(公告)日：2010-01-26

    申请号：US10861199

    申请日：2004-06-03

    申请人： Geert Van Waeg ,  Bruce W. Gibbs ,  Marc Antoon ,  Laura Goodrich

    发明人： Geert Van Waeg ,  Bruce W. Gibbs ,  Marc Antoon ,  Laura Goodrich

    IPC分类号： A61M37/00 ,  C02F1/44

    CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/0218 ,  A61M1/0231 ,  A61M1/30 ,  A61M1/303 ,  A61M1/308 ,  A61M1/3633 ,  A61M1/3692 ,  A61M1/3696 ,  A61M1/3698 ,  A61M2202/0429 ,  A61M2202/0439 ,  A61M2205/123 ,  A61M2202/0071

    摘要： A method and apparatus for red blood collection and filtration is provided wherein a red blood cell collection assembly provides for leukoreduction filtration concurrent with or soon after the red blood cell collection procedure. The procedure preferably involves filtering the separated red blood cells in a high hematocrit (high-crit) state prior to addition of storage solution thereto. Preferably, a storage solution is passed through the leukoreduction filter after the RBCs have been filtered therethrough. The red blood cell collection filtration and storage assembly is preferably preconnected to a blood component separation disposable assembly, including, for example, a centrifuge vessel and a blood removal/return assembly for removing blood from a donor, passing the blood to the centrifuge vessel for separation of the blood into components for collection and providing for filtration of the separated red blood cell component, as described.

    摘要翻译： 提供一种用于红血采集和过滤的方法和装置，其中红细胞收集组件与红细胞收集程序同时或之后提供白细胞减少过滤。 该方法优选包括在加入其中的储存溶液之前以高血细胞比容（高暴击）状态过滤分离的红细胞。 优选地，在通过其过滤RBC之后，使储存溶液通过白细胞减少过滤器。 红细胞收集过滤和储存组件优选地预先连接到血液成分分离一次性组件，包括例如离心机容器和用于从供体去除血液的除血/返回组件，将血液通过离心机容器 将血液分离成用于收集的组分并提供分离的红细胞组分的过滤，如所述。

    METHODS AND DEVICES FOR PROCESSING BLOOD
    4.
    发明申请
    METHODS AND DEVICES FOR PROCESSING BLOOD 有权
    用于处理血液的方法和装置

    公开(公告)号：US20090043237A1

    公开(公告)日：2009-02-12

    申请号：US12187988

    申请日：2008-08-07

    申请人： Robert W. Langley ,  Thomas J. Felt ,  Geert Van Waeg ,  Marlene Adele Bainbridge

    发明人： Robert W. Langley ,  Thomas J. Felt ,  Geert Van Waeg ,  Marlene Adele Bainbridge

    IPC分类号： A61M1/14

    CPC分类号： A61M1/3693 ,  A61M1/304 ,  A61M1/3639 ,  A61M1/3656 ,  A61M1/3696

    摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.

    摘要翻译： 提出了用于血液处理的方法，装置和装置部件。 特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。 一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。 另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。 另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。

    Method for separating a volume of composite liquid into at least two components
    6.
    发明授权
    Method for separating a volume of composite liquid into at least two components 有权
    将复合液体的体积分离成至少两个组分的方法

    公开(公告)号：US07648639B2

    公开(公告)日：2010-01-19

    申请号：US11956696

    申请日：2007-12-14

    申请人： Brian M. Holmes ,  Peter Pihlstedt ,  Geert Van Waeg

    发明人： Brian M. Holmes ,  Peter Pihlstedt ,  Geert Van Waeg

    IPC分类号： B04B1/00 ,  B04B3/00

    CPC分类号： A61M1/3693 ,  A61M1/0209 ,  A61M1/3696 ,  A61M1/3698 ,  A61M2205/331 ,  B01D21/262 ,  B01D2221/10 ,  B04B5/0428 ,  B04B5/0442 ,  B04B13/00 ,  B04B2013/006

    摘要： A method for separating a volume of a composite liquid into at least a first component and a second component is performed in a centrifuge cooperating with a separation bag containing the volume of composite liquid. The separation bag is connected to at least a first component bag and a second component bag. The separation bag is spun so as to centrifuge the volume of composite liquid and cause the sedimentation of the at least first and second components. When the at least first and second components have sedimented, the first component is transferred at least one first transfer flow rate into the first component bag. When the first component has been transferred into the first component bag, the second component is transferred into the intermediate component bag at least one second transfer flow rate that is different from the at least one first transfer flow rate.

    摘要翻译： 在与包含复合液体体积的分离袋配合的离心机中进行将复合液体的体积分离成至少第一成分和第二成分的方法。 分离袋连接到至少第一组分袋和第二组分袋。 旋转分离袋以离心复合液体的体积并引起至少第一和第二组分的沉降。 当至少第一和第二组分沉淀时，第一组分将至少一个第一转移流速转移到第一组分袋中。 当第一组分已被转移到第一组分袋中时，将第二组分转移到中间组分袋中至少一个不同于至少一个第一转移流速的第二转移流速。

    Methods and devices for processing blood
    9.
    发明授权
    Methods and devices for processing blood 有权
    处理血液的方法和装置

    公开(公告)号：US07704454B1

    公开(公告)日：2010-04-27

    申请号：US10680950

    申请日：2003-10-08

    申请人： Robert W. Langley ,  Thomas J. Felt ,  Geert Van Waeg ,  Marlene Adele Bainbridge

    发明人： Robert W. Langley ,  Thomas J. Felt ,  Geert Van Waeg ,  Marlene Adele Bainbridge

    IPC分类号： A61M37/00 ,  C02F1/44

    CPC分类号： A61M1/3693 ,  A61M1/304 ,  A61M1/3639 ,  A61M1/3656 ,  A61M1/3696

    摘要： Methods, devices and device components are presented for blood processing. Particularly, methods, devices and device components are presented for separating blood into blood components and collecting one or more separated blood components, which reduce the incidence of blood vessel infiltration and enhance donor comfort. In one aspect, the invention provides blood processing methods having a return flow rate which decreases systematically during a return time. In another aspect, the invention provides blood processing methods having a removal flow rate, return flow rate or both which are derived from a subject's total blood volume. In another aspect, the present invention provides blood processing methods wherein the fraction by volume of removed blood corresponding to collected components is selected to optimize blood processing efficiency and enhance the purities of collected blood components.

    摘要翻译： 提出了用于血液处理的方法，装置和装置部件。 特别地，提出了用于将血液分离成血液成分并收集一种或多种分离的血液成分的方法，装置和装置部件，其减少血管浸润的发生率并增强供体的舒适度。 一方面，本发明提供了具有在返回时间内系统地减少的返回流速的血液处理方法。 另一方面，本发明提供了血液处理方法，其具有从受检者的总血液体积得到的去除流速，回流流量或两者。 另一方面，本发明提供了血液处理方法，其中选择相应于所收集的组分的去除血液的体积份数以优化血液处理效率并增强收集的血液成分的纯度。