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公开(公告)号:US5514802A
公开(公告)日:1996-05-07
申请号:US416568
申请日:1995-04-04
IPC分类号: C07C237/18 , A61K31/16 , A61K31/47 , A61K31/472 , C07C231/14 , C07C237/20 , C07C317/40 , C07C317/50 , C07C323/60 , C07C323/61 , C07C323/63 , C07D215/48 , C07D217/22 , C07D401/12 , C07D217/16
CPC分类号: C07D401/12 , C07C323/60 , C07D215/48
摘要: The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
摘要翻译: 本发明提供了新的HIV蛋白酶抑制剂,含有这些化合物的药物制剂以及治疗和/或预防HIV感染和/或AIDS的方法。
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公开(公告)号:US5434265A
公开(公告)日:1995-07-18
申请号:US994871
申请日:1992-12-22
IPC分类号: C07C237/18 , A61K31/16 , A61K31/47 , A61K31/472 , C07C231/14 , C07C237/20 , C07C317/40 , C07C317/50 , C07C323/60 , C07C323/61 , C07C323/63 , C07D215/48 , C07D217/22 , C07D401/12 , C07D217/26
CPC分类号: C07D401/12 , C07C323/60 , C07D215/48
摘要: The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating HIV infection.
摘要翻译: 本发明提供了新的HIV蛋白酶抑制剂,含有这些化合物的药物制剂和治疗HIV感染的方法。
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公开(公告)号:US6060484A
公开(公告)日:2000-05-09
申请号:US214533
申请日:1999-01-06
IPC分类号: A61K31/00 , A61K31/135 , A61K31/155 , A61K31/16 , A61K31/17 , A61K31/19 , A61K31/22 , A61K31/222 , A61K31/27 , A61K31/275 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61P31/00 , A61P31/16 , C07C233/11 , C07C233/15 , C07C233/65 , C07C271/28 , C07C271/44 , C07C275/24 , C07C275/30 , C07C279/18 , C07C333/04 , C07C333/08 , C07C335/16 , C07D213/40 , C07D213/57 , C07D215/12 , A61K31/165 , A61K31/445
CPC分类号: C07D213/40 , A61K31/17 , C07C233/11 , C07C233/15 , C07C233/65 , C07C271/44 , C07C275/24 , C07C275/30 , C07C279/18 , C07C333/08 , C07C335/16 , C07D213/57 , C07D215/12 , C07C2101/14 , C07C2101/16 , C07C2103/18 , C07C2103/32
摘要: The present invention provides compounds which inhibit an envelope virus by inhibiting the fusion of the virus with the host cell. The virus may be inhibited in an infected cell, a cell susceptible of infection or a mammal in need thereof.
摘要翻译: PCT No.PCT / US97 / 07431 Sec。 371日期1999年1月6日 102(e)1999年1月6日PCT PCT 1997年5月2日PCT公布。 公开号WO97 / 41846 日期1997年11月13日本发明通过抑制病毒与宿主细胞的融合来提供抑制包膜病毒的化合物。 感染的细胞,易感染的细胞或有需要的哺乳动物可能会抑制病毒。
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公开(公告)号:US5792763A
公开(公告)日:1998-08-11
申请号:US938739
申请日:1997-09-26
IPC分类号: A61K31/343 , A61K31/381 , A61K31/443 , A61K31/4525 , A61P25/06 , A61P43/00 , C07D307/81 , C07D333/58 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , A61K31/54 , A61K31/445 , A61K31/535 , C07D417/00
CPC分类号: C07D405/04 , C07D307/81 , C07D333/58 , C07D405/12 , C07D409/12
摘要: This invention provides novel 5-HT.sub.1F agonists of formula ##STR1## where X, Y, Z,and R are defined in the specification, which are useful for the prevention and treatment of migraine and associated disorders.
摘要翻译: 本发明提供了新颖的式(I)的5-HT1F激动剂,其中X,Y,Z和R在说明书中定义,其可用于预防和治疗偏头痛及相关疾病。
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公开(公告)号:US5505135A
公开(公告)日:1996-04-09
申请号:US379701
申请日:1995-01-27
申请人: James E. Fritz , Scot P. Riley
发明人: James E. Fritz , Scot P. Riley
CPC分类号: F42B3/28
摘要: A pulverable casing (10) includes a housing (12) which is made from a ceramic material and which defines a circular housing closure surface (18). There is a cover (14) on the housing (12). The cover (14) is also made from a ceramic material and defines a circular cover closure surface (20). Cover (14) has a rounded conical exterior surface (24) that defines a skirt angle S of about 120.degree.. The cover closure surface (20) is dimensioned and configured to engage the housing closure surface (18) to define a housing-cover joint (22) which defines a joint angle .alpha. of about 130.degree.. In a particular embodiment, the exterior surface (24) of the cover (14) is rounded to a radius of about 1.8 inches and has a diameter D of about 3.28 inches.
摘要翻译: 可粉化的壳体(10)包括由陶瓷材料制成并限定圆形壳体封闭表面(18)的壳体(12)。 壳体(12)上有一个盖子(14)。 盖(14)也由陶瓷材料制成,并且限定了一个圆形盖封闭表面(20)。 盖(14)具有限定约120度的裙角S的圆锥形外表面(24)。 盖封闭表面(20)的尺寸设计和配置以接合壳体封闭表面(18)以限定限定约130°的关节角度α的壳体 - 盖接头(22)。 在一个具体实施例中,盖(14)的外表面(24)被圆化成约1.8英寸的半径,并且具有约3.28英寸的直径D.
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公开(公告)号:US6125762A
公开(公告)日:2000-10-03
申请号:US108161
申请日:1998-06-30
申请人: James E. Fritz , Steven L. Olson , Jon E. Rydberg
发明人: James E. Fritz , Steven L. Olson , Jon E. Rydberg
摘要: A flat-form separation device (12) is made of two half-section members (22, 22') which are fastened together by a series of fasteners (38) to define therebetween a receiving channel within which an expansion device (40) is received. Aside from the receiving channel and any apertures which are to receive mechanical fasteners, the separation device (12) is solid throughout and free of other channels or cavities. The device (12) includes a pair of joinder flanges formed by mating half-flange segments (28a and 28b), which contain apertures (32 and 34) by which the flat-form separation device (12) may be secured to structures (48, 50) which are to be temporarily joined by the device (12). Because of the cross-sectional profile of the half-section members (22, 22'), they may be made by manufacturing techniques, such as machining, which enable the use of alloys or metals which are much tougher and stronger than those which can be extraded to form prior art hollow-form separation devices (14). Several embodiments of the flat-form separation device (12) are disclosed. Both flat-form separation devices (12) and hollow-form separation devices (14) may be combined in a segmented separation structure (10).
摘要翻译: 平面形式分离装置(12)由两个半部分构件(22,22')制成,它们通过一系列紧固件(38)紧固在一起,以在其间限定一个接收通道,膨胀装置(40) 收到了 除了接收通道和要接收机械紧固件的任何孔之外,分离装置(12)贯穿整个并且没有其它通道或空腔。 装置(12)包括一对通过配合半法兰段(28a和28b)形成的接合法兰,该法兰段包含孔(32和34),平板形分离装置(12)可通过该孔口固定到结构 ,50),其将由所述装置(12)临时连接。 由于半部件(22,22')的横截面轮廓,它们可以通过诸如机械加工的制造技术制成,这使得能够使用比可以使用的那些更坚固和更坚固的合金或金属 被挤出以形成现有技术的中空形式分离装置(14)。 公开了平面形式分离装置(12)的几个实施例。 平面形式分离装置(12)和中空形式分离装置(14)都可以组合在分段分离结构(10)中。
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公开(公告)号:US6021715A
公开(公告)日:2000-02-08
申请号:US52507
申请日:1998-03-31
CPC分类号: F42B15/38
摘要: A manifold (130) is configured to have a body portion (131) having at least one initiation port (132) for receiving an initiation device and at least one tapered boss (138) mounted on the body portion (131). The boss (138) has an elliptical cross-sectional configuration and a boss bore (140) for receiving a fuse or linear explosive charge (16) and it communicates with the initiation port (132). There is a clamp member (160) having an aperture (164) dimensioned and configured to generally conform to the boss (138), and tension means such as a set of bolts (166) for urging the clamp member (160) towards the manifold (130). There may be a bushing material (121) on the boss. The manifold (130) may be coupled to a separation device (23) that includes a frangible joint (24) through which is disposed an expansion member (110). The expansion member (110) may have a containment tube (120) and a linear explosive charge (16) within the tube (120), wherein the tube (120) and the charge (16) protrude from the frangible joint (24). The charge (16) is disposed within the boss bore (140) and the tube is clamped between the boss (138) and the clamp member (160).
摘要翻译: 歧管(130)构造成具有主体部分(131),其具有用于接收起始装置的至少一个起始端口(132)和安装在主体部分(131)上的至少一个锥形凸台(138)。 所述凸台(138)具有椭圆形横截面形状和用于接收熔断器或线性炸药(16)的凸起孔(140),并且其与所述起始端口(132)连通。 具有夹紧构件(160),该夹紧构件(160)具有孔(164),其尺寸设计成大致与凸台(138)相符合;以及拉伸装置,例如一组螺栓(166),用于将夹紧构件(160)朝向歧管 (130)。 在凸台上可能有衬套材料(121)。 歧管(130)可以联接到包括易碎接头(24)的分离装置(23),布置在膨胀构件(110)上。 膨胀构件(110)可以在管(120)内具有容纳管(120)和线性炸药(16),其中管(120)和装料(16)从易碎接头(24)突出。 电荷(16)设置在凸台孔(140)内,并且管被夹紧在凸台(138)和夹紧构件(160)之间。
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公开(公告)号:US5380346A
公开(公告)日:1995-01-10
申请号:US83826
申请日:1993-06-25
申请人: James E. Fritz
发明人: James E. Fritz
CPC分类号: C10L3/00
摘要: Fortified hydrocarbon torch gas is a mixture of a major portion by weight of hydrocarbon base gas and additive selected from 1,2-ethanediol, 1,2-propanediol, 1,3 butanediol, glycerol, diethylene glycol, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol dimethyl ether, ethyl acetate, n-propyl alcohol, isopropyl alcohol, n-butyl alcohol, isobutyl alcohol, sec butyl alcohol, methyl ethyl ketone, propionaldehyde, and butyraldehyde and liquid hydrocarbon fuel fortified with ethylene glycol monomethyl ether or ethyl acetate.
摘要翻译: 强化烃手电筒气是主要部分烃基气体和选自1,2-乙二醇,1,2-丙二醇,1,3-丁二醇,甘油,二甘醇,乙二醇单甲醚,乙二醇的添加剂的混合物 乙醚,乙二醇二甲醚,乙酸乙酯,正丙醇,异丙醇,正丁醇,异丁醇,仲丁醇,甲基乙基酮,丙醛,丁醛和用乙二醇单甲醚强化的液态烃燃料, 乙酸乙酯。
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19.
公开(公告)号:US5236467A
公开(公告)日:1993-08-17
申请号:US898042
申请日:1992-06-12
申请人: James E. Fritz
发明人: James E. Fritz
CPC分类号: C10L3/00
摘要: Base hydrocarbon, preferably LPG gas, is fortified with methyl ethyl ketone and methyl tertbutyl ether in an amount 0.5% to 13%, preferably 5% to 8%, of the base hydrocarbon by weight for use as torch gas, heating or motor fuel. Cutting of ferrous metal can be accomplished even under water by mixing the fortified torch gas with oxygen having a purity as low as 90%.
摘要翻译: 基础烃,优选LPG气体用甲基乙基酮和甲基叔丁基醚加氢,其用量为用作火炬气,加热或发动机燃料的重量的基础烃的0.5%至13%,优选5%至8%。 黑色金属的切割也可以在水中通过将强化的手电筒气体与纯度低至90%的氧气混合来实现。
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公开(公告)号:US06311621B1
公开(公告)日:2001-11-06
申请号:US09455548
申请日:1999-12-06
IPC分类号: F42C1908
CPC分类号: F42C19/00 , F42B3/121 , H05K5/0204
摘要: A shock-resistant electronic circuit assembly (10) is provided in which an electronic circuit is encased in an encapsulation (14) that engages a surrounding enclosure (18) in shock-dispersing contact therewith. The encapsulation may have a plurality of edges (16, 16a, 16b), fins (24) or bosses (70) that bear against the enclosure. The encapsulation may include a shock-absorbing material (14f) disposed against the enclosure to protect the circuit against vibrations and a structural support material such as a casing (14e) to protect the circuit against stress. The circuit assembly (10) may be part of a sheathed initiator assembly (55) that includes a transfer member (58) for converting shock wave energy into electrical energy for the electronic circuit, and the released energy may be converted into a detonation initiation signal. Assembly (55) may be part of a detonator (100) that receives a non-electric initiation signal and detonates following the delay determined by the electronic circuit. The detonator housing (112) or an optional sleeve (22) provides an enclosure for the assembly (55). The circuit encapsulation may include one or more bushings such as O-rings (14g, 14g′) disposed about the circuit casing (14e).
摘要翻译: 提供了一种抗冲击电子电路组件(10),其中电子电路被封装在与周围的外壳(18)接触的密封件(14)中。 封装可以具有承载在外壳上的多个边缘(16,16a,16b),翅片(24)或凸起(70)。 封装可以包括抵靠外壳设置的防震材料(14f),以保护电路免受振动,以及诸如壳体(14e)的结构支撑材料以保护电路免受应力。 电路组件(10)可以是包覆引发器组件(55)的一部分,其包括用于将冲击波能量转换成用于电子电路的电能的转移构件(58),并且释放的能量可以被转换成爆震启动信号 。 组件(55)可以是雷管(100)的一部分,其接收非电启动信号并且引发跟随由电子电路确定的延迟。 雷管壳体(112)或可选的套筒(22)提供用于组件(55)的外壳。 电路封装可以包括一个或多个套管,例如设置在电路外壳(14e)周围的O形环(14g,14g')。
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