摘要:
A pulverable casing (10) includes a housing (12) which is made from a ceramic material and which defines a circular housing closure surface (18). There is a cover (14) on the housing (12). The cover (14) is also made from a ceramic material and defines a circular cover closure surface (20). Cover (14) has a rounded conical exterior surface (24) that defines a skirt angle S of about 120.degree.. The cover closure surface (20) is dimensioned and configured to engage the housing closure surface (18) to define a housing-cover joint (22) which defines a joint angle .alpha. of about 130.degree.. In a particular embodiment, the exterior surface (24) of the cover (14) is rounded to a radius of about 1.8 inches and has a diameter D of about 3.28 inches.
摘要:
A well pipe perforating gun (10) is improved by the utilization of a pulverable support structure (14) to hold the explosive shaped charges (18a, 18b, etc.) and the fireset (20). When the gun (10) is fired, the support structure (14) disintegrates substantially into fragments too small to obstruct the flow of oil or natural gas from a surrounding earth formation into or through the well pipe (12) within which the gun is disposed. Optionally, the support structure (14) is assembled from a number of segments (14a, 14b, etc.) linked together in sequential fashion.
摘要:
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要:
This invention provides novel 5-HT.sub.1F agonists of formula ##STR1## where X, Y, Z,and R are defined in the specification, which are useful for the prevention and treatment of migraine and associated disorders.
摘要:
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optically other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要:
The present invention provides novel HIV protease inhibitors, pharmaceutical formulations containing those compounds and methods of treating and/or preventing HIV infection and/or AIDS.
摘要:
HIV protease inhibitors, obtainable by chemical synthesis, inhibit or block the biological activity of the HIV protease enzyme, causing the replication of the HIV virus to terminate. These compounds, as well as pharmaceutical compositions that contain these compounds and optionally other anti-viral agents as active ingredients, are suitable for treating patients or hosts infected with the HIV virus, which is known to cause AIDS.
摘要:
A flat-form separation device (12) is made of two half-section members (22, 22') which are fastened together by a series of fasteners (38) to define therebetween a receiving channel within which an expansion device (40) is received. Aside from the receiving channel and any apertures which are to receive mechanical fasteners, the separation device (12) is solid throughout and free of other channels or cavities. The device (12) includes a pair of joinder flanges formed by mating half-flange segments (28a and 28b), which contain apertures (32 and 34) by which the flat-form separation device (12) may be secured to structures (48, 50) which are to be temporarily joined by the device (12). Because of the cross-sectional profile of the half-section members (22, 22'), they may be made by manufacturing techniques, such as machining, which enable the use of alloys or metals which are much tougher and stronger than those which can be extraded to form prior art hollow-form separation devices (14). Several embodiments of the flat-form separation device (12) are disclosed. Both flat-form separation devices (12) and hollow-form separation devices (14) may be combined in a segmented separation structure (10).
摘要:
A manifold (130) is configured to have a body portion (131) having at least one initiation port (132) for receiving an initiation device and at least one tapered boss (138) mounted on the body portion (131). The boss (138) has an elliptical cross-sectional configuration and a boss bore (140) for receiving a fuse or linear explosive charge (16) and it communicates with the initiation port (132). There is a clamp member (160) having an aperture (164) dimensioned and configured to generally conform to the boss (138), and tension means such as a set of bolts (166) for urging the clamp member (160) towards the manifold (130). There may be a bushing material (121) on the boss. The manifold (130) may be coupled to a separation device (23) that includes a frangible joint (24) through which is disposed an expansion member (110). The expansion member (110) may have a containment tube (120) and a linear explosive charge (16) within the tube (120), wherein the tube (120) and the charge (16) protrude from the frangible joint (24). The charge (16) is disposed within the boss bore (140) and the tube is clamped between the boss (138) and the clamp member (160).