公开(公告)号：US20230372090A1

公开(公告)日：2023-11-23

申请号：US18228229

申请日：2023-07-31

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI ,  Meni IAMBERGER ,  Aviram BAUM

IPC: A61F2/24 ,  B23P15/00

CPC classification number: A61F2/2418 ,  A61F2/2415 ,  A61F2/2412 ,  B23P15/001 ,  A61F2220/0075 ,  A61F2250/0039 ,  A61F2210/0014 ,  A61F2230/0069 ,  A61F2230/0093 ,  A61F2240/001 ,  A61F2/2436 ,  A61F2220/0025 ,  A61F2250/0063

Abstract: A unitary flexible sheet (612) is folded to define (i) a panel (608); (ii) a first tab (606a), having a first-tab outer layer and a first-tab inner layer, and protruding away from the panel; and (iii) a second tab (606b), having a second-tab outer layer and a second-tab inner layer, and protruding away from the panel. A commissural portion of a first prosthetic leaflet (58a), and a commissural portion of a second prosthetic leaflet (58b) are disposed between the first-tab inner layer and the second-tab inner layer. A first stitching (632) is stitched through the inner layer of each tab, and the commissural portion of each leaflet. A second stitching (634) is stitched through the outer and inner layers of each tab, and the commissural portion of each leaflet. The first-tab outer layer and the second-tab outer layer cover the first stitching. Other embodiments are also described.

公开(公告)号：US20220338985A1

公开(公告)日：2022-10-27

申请号：US17839538

申请日：2022-06-14

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI ,  Meni IAMBERGER

IPC: A61F2/24

Abstract: An apparatus for use at a native valve of a heart of a subject comprises a tubular frame (30) circumscribing a longitudinal axis to define a lumen, a valve member (62) disposed within the lumen and coupled to the tubular frame, an outer frame (40), and a pin (50). The outer frame is composed of a shape-memory alloy. The tubular frame and the pin are composed of a material that is not the shape-memory alloy. The outer frame comprises a flange (42), defines an eyelet (44), and is disposed radially outward from the tubular frame. The pin defines a shaft (52) and a head (54), and couples the outer frame to the tubular frame. The head is disposed against the outer frame, radially outward from the eyelet, the shaft extends from the head through the eyelet to the tubular frame, and the shaft is welded to the tubular frame.

公开(公告)号：US20210196461A1

公开(公告)日：2021-07-01

申请号：US17181722

申请日：2021-02-22

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI ,  Maxim KARALNIK ,  Michael ALBITOV ,  Meni IAMBERGER

IPC: A61F2/24 ,  A61F2/966

Abstract: A delivery tool includes a nosepiece that is fixed to a shaft, and distal to an implant, and an expandable element proximal to the nosepiece. Maximally-expanded, the expandable element (i) has an expanded external diameter at its widest part that is smaller than the expanded internal diameter of a lumen of the frame of the implant, (ii) tapers proximally away from the widest part and from the nosepiece, and (iii) is dimensioned to slide proximally through the lumen of the implant in its expanded state, between leaflets of the implant, and out of the lumen. When non-expanded, the widest part of the expandable element has a non-expanded external diameter that is smaller than the expanded external diameter of the expandable element. In a compressed state of the implant a portion of the expandable element is disposed within the lumen of the frame. Other applications are also described.

公开(公告)号：US20190083263A1

公开(公告)日：2019-03-21

申请号：US16135619

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: A prosthetic valve delivery system may be provided. The prosthetic valve delivery system may include a first catheter and a first steering mechanism configured to bend the first catheter within a first steering plane. The prosthetic valve delivery system may also include a second catheter coaxially arranged within the first catheter and a second steering mechanism configured to bend the second catheter within a second steering plane, different from the first steering plane. Moreover, the prosthetic valve delivery system may include a capsule positioned distal to both the first catheter and the second catheter. The capsule may be configured to retain a prosthetic valve therein during transvascular advancement of the capsule.

公开(公告)号：US20240074856A1

公开(公告)日：2024-03-07

申请号：US18368250

申请日：2023-09-14

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI ,  Meni LAMBERGER

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/243 ,  A61F2/9517

Abstract: A valve frame includes a tubular portion defining a plurality of valve-frame coupling elements disposed circumferentially around a longitudinal axis of the valve frame, and a plurality of arms, extending radially outward from an upstream portion of the tubular portion to define an arm span, and configured to engage tissue in the atrium. An outer frame is coupled to the valve frame, and includes a ring circumscribing the tubular portion, and a plurality of flanges that extend radially outward from the ring to define a flange span, and are configured to engage ventricular tissue. Each arm defines a rigid portion and a flexible portion that is disposed radially outward from the rigid portion, and is more flexible than the rigid portion. The majority of the flexible portion is disposed further radially outward than the flange span. Other embodiments are also described.

公开(公告)号：US20220249230A1

公开(公告)日：2022-08-11

申请号：US17721763

申请日：2022-04-15

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Meni IAMBERGER ,  Aviram BAUM ,  Boaz HARARI

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an expandable valve body having an atrial end, a ventricular end opposite the atrial end, and an intermediate portion extending between the atrial end and the ventricular end. The valve body may include a plurality of struts intersecting at junctions. The prosthetic valve may also include a plurality of tissue anchoring legs extending from junctions within the intermediate portion of the valve body. At least one of the tissue anchoring legs may have a cross-sectional area which is larger by at least 20% than a cross-sectional area of a strut extending between the at least one tissue anchoring leg and an adjacent tissue anchoring leg.

公开(公告)号：US20200297486A1

公开(公告)日：2020-09-24

申请号：US16896858

申请日：2020-06-09

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular valve body and atrial anchors and ventricular anchors extending from the valve body. An atrial anchor may include a pivoting portion configured to extend in an upstream direction when the prosthetic heart valve is in a delivery configuration and in a downstream direction when the prosthetic heart valve is in a deployed-anchor configuration. A portion of a ventricular anchor may be configured to abut the annular valve body when the prosthetic heart valve is arranged in the delivery configuration.

公开(公告)号：US20200129294A1

公开(公告)日：2020-04-30

申请号：US16730090

申请日：2019-12-30

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic heart valves and methods of use of prosthetic heart valves may be provided. In one implementation, a prosthetic heart valve may include an annular outer frame, an inner frame, and at least one connector configured to secure the outer frame to the inner frame. The connector may be spaced apart from at least one of the downstream end of the outer frame or the downstream end of the inner frame. The prosthetic heart valve may be configured to maintain a greater distance between the downstream ends of the outer and inner frames when the prosthetic heart valve is radially compressed than when the prosthetic heart valve is radially expanded.

公开(公告)号：US20200069424A1

公开(公告)日：2020-03-05

申请号：US16678355

申请日：2019-11-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body having atrial anchoring arms and ventricular anchoring legs extending therefrom. The atrial anchoring arms and the ventricular anchoring legs may be configured for independent outward radial deflection. In some embodiments, at least one atrial anchoring arm may include first and third arm segments configured to extend in upstream directions and a second arm segment configured to extend in a downstream direction, the second arm segment situated between the first and third arm segments. The terminal end of the at least one atrial anchoring arm may be configured to be situated upstream from the rest of the arm when the prosthetic valve is radially-expanded.

公开(公告)号：US20200054451A1

公开(公告)日：2020-02-20

申请号：US16585349

申请日：2019-09-27

Applicant: CARDIOVALVE LTD.

Inventor： Ilia HARITON ,  Boaz HARARI

IPC: A61F2/24

Abstract: Prosthetic valves and methods of use of prosthetic valves may be provided. In one implementation, a method of releasing a prosthetic valve from a delivery capsule within a heart may be provided. The delivery capsule may include a distal capsule portion and a proximal capsule portion. The method may include moving the distal capsule portion in a first direction to release ventricular anchoring legs of the prosthetic valve from the delivery capsule and moving the released legs into contact with a native mitral valve. The method may include moving the proximal capsule portion in a second direction to release atrial anchoring arms of the prosthetic valve from the delivery capsule, after contacting the mitral valve with the released legs. The method may include moving the distal capsule portion in the first direction to release an annular valve body of the prosthetic valve from the delivery capsule.