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    Multi-chambered cell culture device to model organ microphysiology
    12.
    发明授权
    Multi-chambered cell culture device to model organ microphysiology 有权

    公开(公告)号：US10570360B2

    公开(公告)日：2020-02-25

    申请号：US15898032

    申请日：2018-02-15

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36

    Abstract: A method of testing an analyte can include using a cell culture device that includes: at least three distinct chambers between the top wall and bottom wall. The chambers can include: an internal chamber defined by at least one porous internal wall; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber.

    MULTI-CHAMBERED CELL CULTURE DEVICE TO MODEL ORGAN MICROPHYSIOLOGY
    15.
    发明申请
    MULTI-CHAMBERED CELL CULTURE DEVICE TO MODEL ORGAN MICROPHYSIOLOGY 有权
    多室细胞培养装置模型有机微生物学

    公开(公告)号：US20150299631A1

    公开(公告)日：2015-10-22

    申请号：US14646715

    申请日：2013-11-26

    Applicant: CFD RESEARCH CORPORATION

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: C12M3/00 ,  C12M1/12 ,  C12M1/36 ,  C12M1/00

    CPC classification number: C12M21/08 ,  C12M23/20 ,  C12M23/26 ,  C12M23/58 ,  C12M25/06 ,  C12M29/00 ,  C12M29/04 ,  C12M41/48

    Abstract: A cell culture device can include: a top wall; a bottom wall; one or more perimeter walls coupled with and extending between the top wall and bottom wall; and at least 3 distinct chambers between the top wall, bottom wall. The one or more perimeter walls can include: an internal chamber defined by at least one porous internal wall and having an internal chamber inlet and an internal chamber outlet; one or more boundary layer chambers having at least an inner boundary layer chamber defined by the at least one porous internal wall and at least one porous inner boundary layer wall, the at least one porous internal wall having a plurality of pores fluidically coupling the central internal chamber to the one or more boundary layer chamber; and an outer chamber defined by an outer porous boundary layer wall of the at least one porous boundary layer walls and the one or more perimeter walls and having an outer chamber inlet and an outer chamber outlet, the outer porous boundary layer wall having a plurality of pores that fluidically couple the outer chamber with the one or more boundary layer chambers. In one aspect, wherein the at least three distinct chambers are nonlinear and/or idealized.

    Abstract translation: 细胞培养装置可以包括：顶壁; 底壁 在顶壁和底壁之间耦合并延伸的一个或多个周边壁; 以及在顶壁，底壁之间的至少3个不同的腔室。 一个或多个周边壁可以包括：由至少一个多孔内壁限定并具有内部室入口和内部室出口的内部室; 一个或多个边界层室具有至少一个由所述至少一个多孔内壁和至少一个多孔内边界层壁限定的内边界层室，所述至少一个多孔内壁具有多个孔隙， 室到一个或多个边界层室; 以及由所述至少一个多孔边界层壁和所述一个或多个周边壁的外部多孔边界层壁限定的外部室，并且具有外部室入口和外部室出口，所述外部多孔边界层壁具有多个 将外室与一个或多个边界层室流体耦合的孔。 在一个方面，其中所述至少三个不同的室是非线性和/或理想化的。

    SYNTHETIC MICROFLUIDIC SYSTEMS FOR TUMOR METASTASIS
    16.
    发明申请
    SYNTHETIC MICROFLUIDIC SYSTEMS FOR TUMOR METASTASIS 有权
    用于肿瘤分化的合成微流体系统

    公开(公告)号：US20140255971A1

    公开(公告)日：2014-09-11

    申请号：US14202511

    申请日：2014-03-10

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: G01N33/50

    CPC classification number: G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

    Abstract: A method of assaying metastasis can include: providing a device of one of the embodiments; introducing the at least one cancer cell into the at least one internal chamber or at least one fluid channel; and studying metastasis of the at least one cancer cell. Optionally: introducing cancer cells into a first internal chamber; detecting escape of the cancer cell from the first internal chamber into the fluid channel; detecting migration of the cancer cell through the fluid channel; detecting adhesion of the cancer cell to a coating on the fluid channel; detecting invasion of the cancer cell into a second internal chamber from the fluid channel; or visualizing metastasis of the cancer cell with a visualization device.

    Abstract translation: 测定转移的方法可以包括：提供实施方案之一的装置; 将至少一个癌细胞引入所述至少一个内室或至少一个流体通道中; 并研究至少一种癌细胞的转移。 任选地：将癌细胞引入第一内室; 检测癌细胞从第一内室进入流体通道的逃逸; 检测癌细胞通过流体通道的迁移; 检测癌细胞与流体通道上的涂层的粘附; 检测来自流体通道的癌细胞侵入第二内室; 或用可视化装置可视化癌细胞的转移。

    SYSTEMS AND METHODS FOR REPERFUSION INJURY
    18.
    发明申请
    SYSTEMS AND METHODS FOR REPERFUSION INJURY 审中-公开

    公开(公告)号：US20200378952A1

    公开(公告)日：2020-12-03

    申请号：US16995734

    申请日：2020-08-17

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant ,  Kevin Daniel Roehm ,  Ketan Harendrakumar Bhatt

    IPC: G01N33/50 ,  G01N33/86

    Abstract: A method of creating a reperfusion injury can include: providing a cell culture device having an internal chamber with at least one port coupled to a perfusion modulating system capable of modulating perfusion in the internal chamber, wherein the internal chamber includes a cell culture; perfusing a fluid through the internal chamber with the perfusion modulating system, wherein the perfusion modulating system includes at least one pump; reducing fluid flow through the internal chamber; reperfusing fluid flow through the internal chamber; and creating a reperfusion injury in the cell culture by the reperfusion of the fluid flow through the internal chamber. The cell culture includes at least one type of tissue cell. The cell culture can include a tissue construct formed of hydrogel and/or extracellular matrix.

    SYNTHETIC MICROFLUIDIC SYSTEMS FOR WOUND HEALING
    20.
    发明申请
    SYNTHETIC MICROFLUIDIC SYSTEMS FOR WOUND HEALING 有权
    合成微血管系统治疗伤口愈合

    公开(公告)号：US20160161469A1

    公开(公告)日：2016-06-09

    申请号：US15041963

    申请日：2016-02-11

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: G01N33/50 ,  G01N33/86

    CPC classification number: G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

    Abstract: A method of assaying wound healing can include: growing cells on the matrix in the first flow channel; introducing an agent that removes the matrix from the junction; introducing a matrix material into the second flow channel so as to form the second matrix in the second flow channel and junction; and detecting cellular migration into the junction onto the second matrix. The agent that removes the matrix can include a biomolecule or chemical agent. The method can include removing cells in the matrix in the junction before introducing the matrix material into the second flow channel. A bioactive agent can be introduced into the junction to determine if it modulates cellular migration and/or clot formation into the intersection openings of tissue and vascular channels.

    Abstract translation: 测定伤口愈合的方法可以包括：在第一流动通道中在基质上生长细胞; 引入从接合处去除基质的试剂; 将基质材料引入到第二流动通道中，以便在第二流动通道和结中形成第二基质; 并检测细胞迁移到第二基质上的结。 去除基质的试剂可以包括生物分子或化学试剂。 该方法可以包括在将基质材料引入第二流动通道之前去除接合中的基体中的细胞。 可以将生物活性剂引入接头以确定其是否调节细胞迁移和/或凝块形成到组织和血管通道的交叉开口中。

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