公开(公告)号：US12289332B2

公开(公告)日：2025-04-29

申请号：US17983048

申请日：2022-11-08

Applicant: CFD Research Corporation

Inventor： Brian Gene Palmer

IPC: H04L9/40

Abstract: The present invention includes systems and methods for providing cybersecurity to web-enabled applications for protection of critical software and host systems. The present invention is operable to build a Hidden Markov model of an application using automated analysis of code and documentation in order to characterize potential state and state transitions. The present invention is also operable to use additional data such as timing and proximity to assess incoming data. Incoming messages are then assigned a trust score based on Bayesian calculations.

公开(公告)号：US12121889B2

公开(公告)日：2024-10-22

申请号：US17502517

申请日：2021-10-15

Applicant: CFD RESEARCH CORPORATION ,  Garry Lynn Freeman, Jr.

Inventor： Joseph Roger Herdy, Jr. ,  Garry Lynn Freeman, Jr.

IPC: G01M9/04 ,  B01J4/00 ,  B01J6/00 ,  C01B13/02 ,  C01B21/02

CPC classification number: B01J4/002 ,  B01J6/00 ,  C01B13/0203 ,  C01B21/02 ,  G01M9/04 ,  B01J2204/007

Abstract: A variable 3D CD nozzle includes: a flexible body defining a flow path having an inlet extending through a narrowed throat to an expanded outlet, wherein the flexible body comprises a plurality of flexible members movably interconnected together; and at least one means for changing a shape of the flexible body to change a dimension or location of the throat plane relative to at least one of the inlet plane or outlet plane. A method of changing airflow in a nozzle includes operating at least one means for changing the shape of the flexible nozzle body to change the dimension or the location of the throat plane. A method of testing an object includes placing a test object in the test region of the test cell and passing a test gas from the outlet opening of the nozzle onto the test object.

公开(公告)号：US20240094297A1

公开(公告)日：2024-03-21

申请号：US18201043

申请日：2023-05-23

Applicant: Purdue Research Foundation ,  CFD Research Corporation

Inventor： Venkatesh Kabra ,  Partha Mukherjee ,  James Cole ,  Paul Northrop ,  Conner Fear

IPC: G01R31/36 ,  G01R31/367 ,  G01R31/3842 ,  G01R31/392

CPC classification number: G01R31/3648 ,  G01R31/367 ,  G01R31/3842 ,  G01R31/392

Abstract: A state of battery testing system is disclosed which includes a charger, a load to be coupled across the battery's positive and negative terminals, a processer adapted to apply a predetermined voltage pulse across the battery's positive and negative terminals, apply the load to the battery, measure and log current through the load as Iexp, and establish a model based on establishing an initial estimation of state of the battery (θ0), and establishing a modeled state of battery (θi) based on a plurality of internal parameters of the battery. The model is adapted to output a model current through the load, inputting θ0 and the plurality of internal parameters of the model to thereby generate Imodel, generate an objective function (f) based on a comparison of Imodel and Iexp, and iteratively optimize θi, and output θoptimal based on the iterations.

公开(公告)号：US20210338664A1

公开(公告)日：2021-11-04

申请号：US16862500

申请日：2020-04-29

Applicant: CFD Research Corporation

Inventor： Narender Singh

IPC: A61K31/497 ,  A61P1/16

Abstract: A method for providing a therapy to a subject that has been exposed to an Aflatoxin B1 can include administering a compound having a structure of Formula 1 to the subject after exposure to the Aflatoxin B1: wherein: R1, R2, R3, R4, R5 and/or R6 are each individually a chemical moiety and n is 1, 2, 3, 4, or 5. The compound can be Amprenavir or a derivative thereof, prodrug thereof, salt thereof, or stereoisomer thereof, or having any chirality at any chiral center, or tautomer, polymorph, solvate, or combination thereof. The prodrug can be Amprenavir phosphate.

公开(公告)号：US20210280088A1

公开(公告)日：2021-09-09

申请号：US16696997

申请日：2019-11-26

Applicant: CFD Research Corporation

Inventor： David Keith Sedberry ,  Vincent J. Harrand ,  Phillip E. Whitley ,  Andrzej Przekwas

IPC: G09B23/34 ,  G01N33/00

Abstract: A modular surrogate can include: a body having an external body surface with an anatomical shape, wherein the body includes an internal chamber with at least one port formed in the body extending inwardly; at least one anatomical module having an external module portion and a module stem coupled thereto, the module stem being received into a corresponding module port of the at least one port, the external module portion having an external module surface with an anatomical shape, the external body surface matches with the external module surface to provide a continuous anatomical shape; at least one sensor located in the at least one anatomical module; and at least one controller, wherein when the at least one anatomical module is coupled with the body, the at least one sensor is capable of being operably coupled with the at least one controller.

公开(公告)号：US20210269868A1

公开(公告)日：2021-09-02

申请号：US17187267

申请日：2021-02-26

Applicant: CFD Research Corporation

Inventor： David Edwin Gaddes, III ,  Ketan Harendrakumar Bhatt ,  Balabhaskar Prabhakarpandian

IPC: C12Q1/6853 ,  C12Q1/6832 ,  C12Q1/6816

Abstract: A primer composition for amplifying a target nucleic acid of a plurality of target organisms can include: a first primer having in order: 3′-a first target specific sequence; a melt key region; and a first super primer region, wherein the first target specific sequence includes a nucleic acid sequence that specifically hybridizes with a first unique nucleic acid sequence of a first target organism over nucleic acid sequences of other organisms, the melt key region includes a nucleic acid sequence that has less than full identity with a melt key probe and a complement of the melt key region hybridizes with the melt key probe with at least one nucleotide mismatch with the melt key probe, and the first super primer region includes a nucleic acid sequence that is common to the plurality of target organisms.

公开(公告)号：US20210187332A1

公开(公告)日：2021-06-24

申请号：US17119621

申请日：2020-12-11

Applicant: CFD Research Corporation

Inventor： Zachary William Wright ,  William Christopher Krolick ,  Wyatt Gilbert Ramos

IPC: A62B3/00

Abstract: A door breach device can include: an elongate shaft having a first end and an opposite second end; a pivot mechanism at the first end of the shaft; a spearhead rotatably coupled with the pivot mechanism and having a tip on a tip-side of the pivot mechanism and having a shaft cavity on a shaft-side, where the shaft cavity is adapted to receive the shaft therein; a restraint slidably received on the shaft-side of the spearhead and on the shaft; a handle protruding from the shaft; and a hitch at the second end of the shaft. A method of breaching a door can include: forcing the spearhead through a door until the restraint releases the spearhead and the spearhead rotates by the pivot mechanism so as to form an angle with the shaft; and pulling the spearhead against the door until the door is breached.

公开(公告)号：US20210116338A1

公开(公告)日：2021-04-22

申请号：US17074007

申请日：2020-10-19

Applicant: CFD RESEARCH CORPORATION

Inventor： David Edwin Gaddes, III ,  Balabhaskar Prabhakarpandian ,  Ketan Harendrakumar Bhatt

IPC: G01N1/40 ,  B01L3/00

Abstract: A fluidic device can include: a plurality of fluid conduits, each fluid conduit including a first conduit portion separated from a second conduit portion; and at least one transport body that is movably positioned between the first conduit portion and the second conduit portion of each fluid conduit. The at least one transport body can include: at least one port adapted to be aligned with a first conduit portion and a second conduit portion of at least one first conduit so as to fluidly couple the first conduit portion with the second conduit portion; and at least one blocking body portion adapted to be aligned with a first conduit portion and a second conduit portion of at least one second conduit so as to fluidly isolate the first conduit portion from the second conduit portion of the at least one second conduit.

公开(公告)号：US20200083543A1

公开(公告)日：2020-03-12

申请号：US16503261

申请日：2019-07-03

Applicant: CFD Research Corporation

Inventor： Pyoungho CHOI ,  Sameer Singhal ,  Joe Don Edington

IPC: H01M6/36 ,  H01M4/06

Abstract: A thermal battery can include: an anode of lithium alloy; a metal-fluoride cathode having Ni; and an electrolyte composition in contact with the anode and cathode. The electrolyte composition can be a tertiary electrolyte composition of LiF—LiCl—Li2SO4. A thermal battery can also include: an anode of lithium alloy; a metal-fluoride cathode having an oxide selected from V2O5 or LiVO3; and an electrolyte composition in contact with the anode and cathode. In one aspect, a metal of the metal fluoride cathode includes Ni, Fe, V, Cr, Mn, Co, or mixture thereof. In one aspect, the metal-fluoride cathode includes NiF2, FeF3, VF3, CrF3, MnF3, CoF3, or a mixture thereof. A method of providing electricity can include: providing an electronic device having a thermal battery with a metal-fluoride cathode having Ni and/or having an oxide selected from V2O5 or LiVO3; and discharging the thermal battery to provide electricity.

公开(公告)号：US10012640B2

公开(公告)日：2018-07-03

申请号：US14768154

申请日：2014-02-14

Applicant: CFD Research Corporation

Inventor： Kapil Pant ,  Balabhaskar Prabhakarpandian

IPC: C12M1/00 ,  C12M3/00 ,  B01L3/00 ,  G01N33/50 ,  C12M3/06 ,  C12M1/12 ,  C12M1/34 ,  C12M1/36 ,  C12M1/42

CPC classification number: G01N33/5008 ,  B01L3/5025 ,  B01L3/502715 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2300/0874 ,  B01L2400/0487 ,  C12M23/16 ,  C12M23/34 ,  C12M25/14 ,  C12M29/00 ,  C12M29/04 ,  C12M35/08 ,  C12M41/00 ,  C12M41/48

Abstract: A cell culture assay device can include: a substrate having a plurality of discrete microfluidic networks and a plurality of wells over the discrete microfluidic networks, each discrete microfluidic network having one or more wells fluidly coupled thereto, the wells extending upward from the discrete microfluidic networks; and a manifold body coupled with the substrate and having at least one fluid conduit pair for each microfluidic network and/or each well, each fluid conduit pair including a fluid inlet conduit and a fluid outlet conduit fluidly coupled to a corresponding microfluidic network and/or well. The substrate can be formed from a substrate base having the microfluidic networks coupled to a well plate having the wells associated with the microfluidic networks.