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    SYNTHETIC MICROFLUIDIC SYSTEMS FOR HYPOXIA
    2.
    发明申请
    SYNTHETIC MICROFLUIDIC SYSTEMS FOR HYPOXIA 审中-公开
    HYPOXIA合成微流控系统

    公开(公告)号：US20140255970A1

    公开(公告)日：2014-09-11

    申请号：US14202491

    申请日：2014-03-10

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: G01N33/50

    CPC classification number: G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

    Abstract: A cell culture device can include: an internal chamber configured for an internal cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the internal chamber; at least one fluid channel bordering the internal chamber that is configured for a channel cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the fluid channel; and a wall separating the internal chamber and at least one fluid channel having gaps that fluidly couple the internal chamber with the at least one fluid channel, wherein the perfusion modulating device causes reduced fluid flow. The internal chamber can include a first cell type and the at least one fluid channel includes a second cell type. The first cell type has an ischemic zone in the middle, a non-ischemic zone adjacent with the at least one fluid channel, and a border zone between the ischemic zone and non-ischemic zone. In one aspect, the internal chamber and at least one fluid channel are modeled from physiological features. In one aspect, the internal chamber and at least one fluid channel are modeled from idealized features.

    Abstract translation: 细胞培养装置可以包括：配置用于内部细胞培养物的内部室，其具有耦合到能够调节内部腔室灌注的灌注调节装置的至少一个端口; 至少一个与所述内室邻接的流体通道，其构造成用于通道细胞培养，所述通道细胞培养物具有至少一个端口，所述至少一个端口耦合到能够调节所述流体通道中的灌注的灌注调节装置; 以及分隔内室和至少一个流体通道的壁，所述至少一个流体通道具有使内室与至少一个流体通道流体连接的间隙，其中灌注调节装置引起减少的流体流动。 内部腔室可以包括第一细胞类型，并且所述至少一个流体通道包括第二细胞类型。 第一细胞类型在中间具有缺血区，与至少​​一个流体通道相邻的非缺血区，以及缺血区与非缺血区之间的边界区。 在一个方面，内部室和至少一个流体通道由生理特征建模。 在一个方面，内部室和至少一个流体通道由理想特征建模。

    Synthetic microfluidic systems for wound healing and hemostasis
    4.
    发明授权
    Synthetic microfluidic systems for wound healing and hemostasis 有权
    用于伤口愈合和止血的合成微流体系统

    公开(公告)号：US09291614B2

    公开(公告)日：2016-03-22

    申请号：US14202721

    申请日：2014-03-10

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: C12M3/00 ,  G01N33/50 ,  G01N33/86 ,  B01L3/00

    CPC classification number: G01N33/5029 ,  B01L3/5027 ,  G01N33/5005 ,  G01N33/5011 ,  G01N33/5061 ,  G01N33/5088 ,  G01N33/86 ,  G01N2333/4703 ,  G01N2333/70525

    Abstract: A method of assaying wound healing can include: growing cells on the matrix in the first flow channel; introducing an agent that removes the matrix from the junction; introducing a matrix material into the second flow channel so as to form the second matrix in the second flow channel and junction; and detecting cellular migration into the junction onto the second matrix. The agent that removes the matrix can include a biomolecule or chemical agent. The method can include removing cells in the matrix in the junction before introducing the matrix material into the second flow channel. A bioactive agent can be introduced into the junction to determine if it modulates cellular migration and/or clot formation into the intersection openings of tissue and vascular channels.

    Abstract translation: 测定伤口愈合的方法可以包括：在第一流动通道中在基质上生长细胞; 引入从接合处去除基质的试剂; 将基质材料引入到第二流动通道中，以便在第二流动通道和结中形成第二基质; 并检测细胞迁移到第二基质上的结。 去除基质的试剂可以包括生物分子或化学试剂。 该方法可以包括在将基质材料引入第二流动通道之前去除接合中的基体中的细胞。 可以将生物活性剂引入接头以确定其是否调节细胞迁移和/或凝块形成到组织和血管通道的交叉开口中。

    MICROFLUIDIC ASSAY IN IDEALIZED MICROVASCULAR NETWORK FOR CHARACTERIZATION OF LEUKOCYTE ADHESION CASCADE
    5.
    发明申请
    MICROFLUIDIC ASSAY IN IDEALIZED MICROVASCULAR NETWORK FOR CHARACTERIZATION OF LEUKOCYTE ADHESION CASCADE 有权
    用于表征白云石粘合剂的理想化微血管网络的微流感测定

    公开(公告)号：US20130149735A1

    公开(公告)日：2013-06-13

    申请号：US13743171

    申请日：2013-01-16

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: C12Q1/02

    CPC classification number: C12Q1/025 ,  G01N33/5008 ,  G01N33/5029 ,  G01N33/5032 ,  G01N33/5047 ,  G01N33/54366 ,  G01N33/56972

    Abstract: Methods of assaying the leukocyte adhesion cascade (LAC) and monitoring leukocyte rolling, adhesion, and/or migration can be implemented with an apparatus that includes an idealized microvascular network (IMN) of one or more interconnected idealized flow channels in fluid communication through a porous wall with a tissue space (e.g., idealized tissue space). The methods of assaying the LAC can be implemented with means for quantifying modulation of the leukocyte adhesion cascade. Methods of assaying the LAC can be implemented with the device and one or more active agents to monitor leukocyte rolling, adhesion, and/or migration in the presence of absence of the active agent. Migration can be through the idealized flow channels, through the porous wall, and/or into the tissue space.

    Abstract translation: 测定白细胞粘附级联（LAC）和监测白细胞滚动，粘附和/或迁移的方法可以用包括理想的微血管网络（IMN）的装置来实现，所述设备包括一个或多个互连的理想化流动通道，其通过多孔 具有组织空间的壁（例如，理想化的组织空间）。 可以用用于量化白细胞粘附级联调节的方法来实施测定LAC的方法。 可以使用该装置和一种或多种活性剂来实施测定LAC的方法，以在存在活性剂的情况下监测白细胞的滚动，粘附和/或迁移。 迁移可以通过理想的流动通道，通过多孔壁和/或进入组织空间。

    Synthetic microfluidic systems for hypoxia
    6.
    发明授权
    Synthetic microfluidic systems for hypoxia 有权

    公开(公告)号：US10775364B2

    公开(公告)日：2020-09-15

    申请号：US15017125

    申请日：2016-02-05

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: G01N33/50 ,  G01N33/86 ,  B01L3/00

    Abstract: A method of inducing ischemia includes: providing a cell culture device having a first cell culture in an internal chamber and a second cell culture in at least one fluid channel and a perfusion modulating system that causes changes in oxygen flow in the internal chamber and/or at least one fluid channel; flowing liquid media having oxygen through the internal chamber and at least one fluid channel of the cell culture device; modulating oxygen perfusion in the internal chamber with the perfusion modulating system by varying and selectively blocking the flow rate of at least one of the liquid media or oxygen through the internal chamber to induce varying levels of ischemia; and assaying for ischemia in the first cell culture.

    SYNTHETIC MICROFLUIDIC SYSTEMS FOR HYPOXIA
    9.
    发明申请
    SYNTHETIC MICROFLUIDIC SYSTEMS FOR HYPOXIA 审中-公开
    HYPOXIA合成微流控系统

    公开(公告)号：US20160153970A1

    公开(公告)日：2016-06-02

    申请号：US15017125

    申请日：2016-02-05

    Applicant: CFD Research Corporation

    Inventor： Balabhaskar Prabhakarpandian ,  Kapil Pant

    IPC: G01N33/50

    Abstract: A cell culture device can include: an internal chamber configured for an internal cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the internal chamber; at least one fluid channel bordering the internal chamber that is configured for a channel cell culture that has at least one port coupled to a perfusion modulating device capable of modulating perfusion in the fluid channel; and a wall separating the internal chamber and at least one fluid channel having gaps that fluidly couple the internal chamber with the at least one fluid channel, wherein the perfusion modulating device causes reduced fluid flow. The internal chamber can include a first cell type and the at least one fluid channel includes a second cell type. The first cell type has an ischemic zone in the middle, a non-ischemic zone adjacent with the at least one fluid channel, and a border zone between the ischemic zone and non-ischemic zone. In one aspect, the internal chamber and at least one fluid channel are modeled from physiological features. In one aspect, the internal chamber and at least one fluid channel are modeled from idealized features.

    Abstract translation: 细胞培养装置可以包括：配置用于内部细胞培养物的内部室，其具有耦合到能够调节内部腔室灌注的灌注调节装置的至少一个端口; 至少一个与所述内室邻接的流体通道，其构造成用于通道细胞培养，所述通道细胞培养物具有至少一个端口，所述至少一个端口耦合到能够调节所述流体通道中的灌注的灌注调节装置; 以及分隔内室和至少一个流体通道的壁，所述至少一个流体通道具有使内室与至少一个流体通道流体连接的间隙，其中灌注调节装置引起减少的流体流动。 内部腔室可以包括第一细胞类型，并且所述至少一个流体通道包括第二细胞类型。 第一细胞类型在中间具有缺血区，与至少​​一个流体通道相邻的非缺血区，以及缺血区与非缺血区之间的边界区。 在一个方面，内部室和至少一个流体通道由生理特征建模。 在一个方面，内部室和至少一个流体通道由理想特征建模。

    BIPOLAR ELECTRODE SAMPLE PREPARATION DEVICES
    10.
    发明申请
    BIPOLAR ELECTRODE SAMPLE PREPARATION DEVICES 有权
    双极电极样品制备装置

    公开(公告)号：US20140251813A1

    公开(公告)日：2014-09-11

    申请号：US14202105

    申请日：2014-03-10

    Applicant: CFD Research Corporation

    Inventor： Yi Wang ,  Hongjun Song ,  Kapil Pant

    IPC: G01N27/447

    CPC classification number: G01N27/44769 ,  B01L3/502753 ,  B01L3/502761 ,  B01L2200/0636 ,  B01L2200/0652 ,  B01L2300/0864 ,  B01L2400/0415 ,  B01L2400/0487 ,  B03C5/026 ,  B03C2201/26 ,  C07K1/24 ,  G01N15/0266 ,  G01N30/0005 ,  G01N2001/4038 ,  G01N2015/0288 ,  G01N2030/0065

    Abstract: An analyte selection device can include: a body defining a fluid channel having a channel inlet and channel outlet; a bipolar electrode (BPE) between the inlet and outlet; one of an anode or cathode electrically coupled with the BPE on a channel inlet side of the BPE and the other of the anode or cathode electrically coupled with the BPE on a channel outlet side of the BPE; and an electronic system operably coupled with the anode and cathode so as to polarize the BPE. The fluid channel can have any shape or dimension. The channel inlet and channel outlet can be longitudinal or lateral with respect to the longitudinal axis of the channel. The BPE can be any metallic member, such as a flat plate on a wall or mesh as a barrier BPE. The anode and cathode can be located at a position that polarizes the BPE.

    Abstract translation: 分析物选择装置可以包括：主体，其限定具有通道入口和通道出口的流体通道; 入口和出口之间的双极电极（BPE）; 在BPE的通道入口侧上与BPE电耦合的阳极或阴极中的一个，阳极或阴极中的另一个在BPE的通道出口侧与BPE电耦合; 以及与阳极和阴极可操作地耦合以便使BPE偏振的电子系统。 流体通道可以具有任何形状或尺寸。 通道入口和通道出口可以相对于通道的纵向轴线纵向或横向。 BPE可以是任何金属构件，例如作为屏障BPE的壁或网上的平板。 阳极和阴极可以位于使BPE偏振的位置。

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