公开(公告)号：US12018047B2

公开(公告)日：2024-06-25

申请号：US17282855

申请日：2019-11-12

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Joo Young Lee ,  Chang Suk Lee ,  Jin Woo Jeon ,  Jun Ok Moon ,  Jin Seung Park

IPC: C07K1/30 ,  B01J23/02 ,  C07C319/12 ,  C07C319/26 ,  C07K1/02

CPC classification number: C07K1/306 ,  B01J23/02 ,  C07C319/12 ,  C07C319/26 ,  C07K1/02 ,  C07B2200/13

Abstract: Provided is a method of preparing an N-acetyl dipeptide and an N-acetyl amino acid, the method including producing the N-acetyl dipeptide and the N-acetyl amino acid by reaction of an amino acid with acetic anhydride or acetyl chloride.

公开(公告)号：US20210368825A1

公开(公告)日：2021-12-02

申请号：US17291416

申请日：2019-04-11

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Jinseung Park ,  Jinwoo Jeon ,  Jun Ok Moon ,  Joo Young Lee ,  Hong-Gu Lee

IPC: A23K20/142 ,  A61K31/405 ,  A23K50/10 ,  A23K50/60

Abstract: Provided are a feed additive composition for dairy cattle including N-acetyl-L-tryptophan (NALT), and more particularly, a feed additive composition including N-acetyl-L-tryptophan as an active ingredient for increasing feed intake of dairy cattle, increasing weight of calves born from dairy cattle, increasing milk yield of dairy cattle, increasing milk protein yield of dairy cattle, and enhancing immunity of calves born from dairy cattle; a feed including the feed additive composition for dairy cattle; and methods of increasing feed intake of dairy cattle, increasing weight of calves born from dairy cattle, increasing milk yield of dairy cattle, increasing milk protein yield of dairy cattle, enhancing immunity of calves born from dairy cattle, and breeding dairy cattle, the methods including feeding the dairy cattle with the feed additive composition or feed for dairy cattle including N-acetyl-L-tryptophan as an active ingredient.
The N-acetyl-L-tryptophan (NALT) according to the present disclosure increases feed intake of dairy cattle, increases weight of calves born from dairy cattle, increases milk yield of dairy cattle, increases milk protein yield of dairy cattle, and enhances immunity of calves born from dairy cattle, and thus it may be effectively used in a feed additive composition or a feed as an active ingredient.

公开(公告)号：US10961390B2

公开(公告)日：2021-03-30

申请号：US16604988

申请日：2018-04-13

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ji Eun Kim ,  Chang Suk Lee ,  Jun Ok Moon ,  Young Lyeol Yang ,  Chang Yub Oh ,  Hang Duk Roh ,  Do Yong Sim ,  Kwang Myung Cho ,  Jin Woo Choi

IPC: C08L77/04 ,  C08K5/053 ,  C08K5/1545 ,  C08K7/02

Abstract: Provided is a binder composition including polylysine and at least one reducing sugar or a derivative thereof, wherein the polylysine has, in a 1H NMR spectrum thereof, a first peak at 3.2 ppm to 3.4 ppm and a second peak at 3.8 ppm to 4.0 ppm, wherein a ratio (A:B) of an area of the first peak (A) to an area of the second peak (B) is 70:30 to 98:2.

公开(公告)号：US10590446B2

公开(公告)日：2020-03-17

申请号：US14362036

申请日：2012-10-17

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Sang Hee Park ,  Jun Ok Moon ,  Sang Jo Lim ,  Do Hyun Kwon ,  Kyung Han Lee ,  Jin Suck Sung ,  Hyun Joon Kim

IPC: C12P13/08 ,  C12P17/10 ,  C12P25/00 ,  C12P17/12 ,  C12R1/15 ,  A23K20/142 ,  C12N1/20

Abstract: The present invention relates to a method for producing highly-concentrated L-amino acid and riboflavin simultaneously, and a microorganism for simultaneously producing L-amino acid and riboflavin. Specifically, the present invention relates to a modified microorganism for producing L-lysine or L-threonine, and riboflavin simultaneously, wherein the microorganism belonging to Corynebacterium sp. capable of producing L-lysine or L-threonine is modified by enhancing the activity of an enzyme family expressed by a rib operon which contains riboflavin biosynthesis gene family. Also, the present invention relates to a method for the simultaneous production of L-lysine or L-threonine, and riboflavin using the modified microorganism, and relates to a formulation or granular formulation, feed, and feed additive, containing L-lysine or L-threonine, and riboflavin produced from a culture medium of the modified microorganism.

公开(公告)号：US20190292526A1

公开(公告)日：2019-09-26

申请号：US16426453

申请日：2019-05-30

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Lan Huh ,  Jun Ok Moon ,  Hyun Won Bae ,  Hyung Joon Kim ,  Sung Ki Song

IPC: C12N9/02 ,  C12N15/77 ,  C12P13/04 ,  C12P13/08

Abstract: The present disclosure relates to a novel pyruvate dehydrogenase variant, a polynucleotide encoding the pyruvate dehydrogenase variant, a microorganism of the genus Corynebacterium producing L-amino acid, which includes the pyruvate dehydrogenase variant, and a method for producing an L-amino acid using the microorganism.

公开(公告)号：US09938546B2

公开(公告)日：2018-04-10

申请号：US15419177

申请日：2017-01-30

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Kwang Ho Lee ,  Sang Jo Lim ,  Jun Ok Moon ,  Jae Woo Jang ,  Su Jin Park ,  Sang Hee Park

IPC: C12P13/08 ,  C12N9/00 ,  C12N9/10 ,  C12N15/52 ,  C12N15/74 ,  C12N9/12 ,  C12N15/63

CPC classification number: C12P13/08 ,  C12N9/1022 ,  C12N9/1217 ,  C12N9/93 ,  C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12Y202/01001 ,  C12Y207/02004 ,  C12Y604/01001 ,  Y02P20/52

Abstract: The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1; hereinafter, referred to as Tkt) or pyruvate carboxylase (EC:6.4.1.1; hereinafter, referred to as Pyc), in which the initiation codon is substituted with ATG, a vector including the same, a microorganism transformed with the vector, and a method for producing L-lysine using the same.

公开(公告)号：US20160040200A1

公开(公告)日：2016-02-11

申请号：US14923825

申请日：2015-10-27

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： So Yeon Rah ,  Lan Huh ,  Chang Gyeom Kim ,  Kwang Ho Lee ,  Jun Ok Moon ,  Kyung Han Lee ,  Jin Seok Sung ,  Hyung Joon Kim

IPC: C12P13/08 ,  C12N9/12 ,  C12N9/92

CPC classification number: C12P13/08 ,  C12N9/1205 ,  C12N9/92 ,  C12Y207/01017 ,  C12Y503/01005 ,  Y02P20/52

Abstract: The present invention relates to microorganisms of corynebacterium which can utilize xylose and to a method for producing L-lysine using same. More particularly, the present invention relates to microorganisms of corynebacterium which are modified, in which genes encoding xylose isomerase and xylulokinase which are xylose synthases are introduced to express the xylose synthase. The present invention also relates to a method for producing L-lysine, comprising a step of culturing the modified microorganisms of corynebacterium using xylose as a carbon source, and recovering L-lysine from the culture.

Abstract translation: 本发明涉及能够利用木糖的棒状杆菌的微生物和使用其的L-赖氨酸的制造方法。 更具体地，本发明涉及被修饰的棒状杆菌的微生物，其中引入木糖异构酶和木酮糖激酶的基因是木糖合成酶来表达木糖合酶。 本发明还涉及L-赖氨酸的制造方法，其特征在于，包括使用木糖作为碳源培养棒状杆菌的修饰微生物并从培养物中回收L-赖氨酸的步骤。

公开(公告)号：US12227676B2

公开(公告)日：2025-02-18

申请号：US17254167

申请日：2019-08-30

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ji Ho Hwang ,  Young Lyeol Yang ,  Chang Yub Oh ,  Chang Suk Lee ,  Kyung Su Na ,  Jun Ok Moon

IPC: C09J11/06

Abstract: Provided is an adhesive composition including lysine, alpha ketoglutaric acid, and water, wherein the lysine and the alpha ketoglutaric acid are present in the form of an aqueous salt solution and do not form precipitates in the aqueous solution.

公开(公告)号：US12037610B2

公开(公告)日：2024-07-16

申请号：US17452565

申请日：2021-10-27

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： So Yeon Hong ,  Jinseung Park ,  Hye Min Park ,  Su Jin Choi ,  Jun Ok Moon ,  Sung Gun Lee ,  Jinwoo Jeon

IPC: C12N9/10 ,  C12N15/63 ,  C12N15/70 ,  C12N15/77 ,  C12N15/81 ,  C12P13/12

CPC classification number: C12N9/1025 ,  C12N9/10 ,  C12N15/63 ,  C12N15/70 ,  C12N15/77 ,  C12N15/81 ,  C12P13/12 ,  C12Y203/01001

Abstract: The present disclosure relates to a polypeptide having an acyltransferase activity or a microorganism including the same; a composition for preparing N-acetyl-L-methionine, the composition including the polypeptide or microorganism; and a method of preparing N-acetyl-L-methionine using the polypeptide or microorganism. Further, the present disclosure relates to a polynucleotide encoding the polypeptide and an expression vector including the polynucleotide. Since the microorganism including a novel acyltransferase according to the present disclosure has enhanced acyltransferase activity, this microorganism can be efficiently used for producing N-acetyl-L-methionine by acetylating L-methionine.

公开(公告)号：US10676512B2

公开(公告)日：2020-06-09

申请号：US15508662

申请日：2015-09-04

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Lan Huh ,  Kwang Ho Lee ,  Hyung Joon Kim ,  Jun Ok Moon ,  Song-Gi Ryu

IPC: C12N9/12 ,  C07K14/34 ,  C12P13/08 ,  C12R1/15

Abstract: The present disclosure relates to a novel modified RNA polymerase sigma factor A (SigA) polypeptide; a polynucleotide encoding the same; a microorganism containing the polypeptide; and a method for producing L-lysine using the microorganism.