公开(公告)号：US20230000475A1

公开(公告)日：2023-01-05

申请号：US17855530

申请日：2022-06-30

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Lishan Aklog ,  Richard Yazbeck ,  Michael Boutillette ,  Brian deGuzman ,  David Wurtman

IPC: A61B10/04

Abstract: Provided herein are methods and a device for collecting biological samples. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.

公开(公告)号：US20180327849A1

公开(公告)日：2018-11-15

申请号：US15568334

申请日：2016-04-20

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Kishore Guda ,  Amitabh Chak ,  Anne-Marie Kieber-Emmons

IPC: C12Q1/6886

CPC classification number: C12Q1/6886 ,  C12N15/111 ,  C12N15/113 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: A method of analyzing tissue in a subject having or suspected of having cancer includes obtaining an expression profile from a sample of tissue obtained from the subject, wherein the expression profile comprises the level of at least one esophageal adenocarcinoma associated lincRNA selected from the group consisting of linc-PRKD, lincRTL, lincMIA, lincNAV, and lincTMEM.

公开(公告)号：US20170204470A1

公开(公告)日：2017-07-20

申请号：US15413108

申请日：2017-01-23

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Joseph Willis ,  Amitabh Chak ,  Rom Leidner

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C07H21/04 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/154 ,  C12Q2600/158 ,  C12Q2600/16

Abstract: This application describes methods and compositions for detecting and treating vimentin-associated neoplasia. Differential methylation of the vimentin nucleotide sequences has been observed in vimentin-associated neoplasia such as neoplasia of the upper or lower gastrointestinal tract, pancreas, and/or bladder.

公开(公告)号：US20160317132A1

公开(公告)日：2016-11-03

申请号：US15103638

申请日：2014-12-12

Applicant: CASE WESTERN RESERVE UNIVERSITY

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Seidlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

Abstract translation: 用于收集患者中的生物样品的装置包括具有第一轴向端部和第二轴向端部的收集部。 第二轴向端部具有折叠位置和展开位置。 当第二轴向端部在折叠位置和展开位置之间移动时，第二轴向端部相对于第一轴向端部在轴向方向上移动。 第二轴向端部沿轴向延伸到第一轴向端部，并且在处于折叠位置时具有凹形。 当处于展开位置时，第二轴向端部是凸形的。

公开(公告)号：US12258632B2

公开(公告)日：2025-03-25

申请号：US16315405

申请日：2017-07-05

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Helen Moinova ,  Amitabh Chak ,  Joseph Willis ,  Thomas LaFramboise

IPC: C12Q1/68 ,  C12Q1/6827 ,  C12Q1/6853 ,  C12Q1/6886 ,  G01N33/574

Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.

公开(公告)号：US20230000474A1

公开(公告)日：2023-01-05

申请号：US17855515

申请日：2022-06-30

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis

IPC: A61B10/04 ,  A61B5/00

Abstract: Provided herein are methods and a device for collecting biological samples from a subject. In particular, the present disclosure relates to a device designed to specifically capture samples within the target areas of a patient for specific cell collection for particular diagnosis.

公开(公告)号：US20220154294A1

公开(公告)日：2022-05-19

申请号：US17590986

申请日：2022-02-02

Applicant: Case Western Reserve University

Inventor： Sanford D. Markowitz ,  Helen Moinova ,  Amitabh Chak ,  Joseph Willis ,  Thomas LaFramboise

IPC: C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6853 ,  G01N33/574

Abstract: The disclosure provides methods for identifying genomic loci (e.g., vimentin and/or SqBE18) that are differentially methylated in metaplasias (e.g., Barrett's esophagus) and/or neoplastic cancers (e.g., esophageal cancers). Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have gastrointestinal metaplasias and/or neoplasias.

公开(公告)号：US20220096063A1

公开(公告)日：2022-03-31

申请号：US17643335

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20220096061A1

公开(公告)日：2022-03-31

申请号：US17643320

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.

公开(公告)号：US20220096060A1

公开(公告)日：2022-03-31

申请号：US17643299

申请日：2021-12-08

Applicant: Case Western Reserve University

Inventor： Sanford Markowitz ,  Amitabh Chak ,  Joseph Willis ,  Jeffrey Silver Taggart ,  Rebecca Blice ,  Dean Secrest ,  Dennis Siedlak

IPC: A61B10/02

Abstract: A device for collecting a biological sample in a patient includes a collection portion having a first axial end portion and a second axial end portion. The second axial end portion has a collapsed position and an expanded position. The second axial end portion moves in an axial direction relative to the first axial end portion when the second axial end portion moves between the collapsed position and the expanded position. The second axial end portion extends axially into the first axial end portion and has a concave shape when in the collapsed position. The second axial end portion is convex when in the expanded position.