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11.发明申请公开(公告)号：US20200041595A1
公开(公告)日：2020-02-06
申请号：US16603335
申请日：2018-04-06
发明人： Chris Flask , Christian Anderson , Xin Yu , Nicole Steinmetz , Mark A. Griswold , Susann Brady-Kalnay
摘要： The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.
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公开(公告)号：US11654204B2
公开(公告)日：2023-05-23
申请号：US17335557
申请日：2021-06-01
发明人： Nicole Steinmetz , Michael Bruckman
CPC分类号： A61K49/1896 , A61K49/1884 , C12N7/00 , C12N2770/00031
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
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公开(公告)号：US20220088228A1
公开(公告)日：2022-03-24
申请号：US17335557
申请日：2021-06-01
发明人： Nicole Steinmetz , Michael Bruckman
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
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公开(公告)号：US11020497B2
公开(公告)日：2021-06-01
申请号：US16149828
申请日：2018-10-02
发明人： Nicole Steinmetz , Michael Bruckman
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
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公开(公告)号：US10086095B2
公开(公告)日：2018-10-02
申请号：US14434435
申请日：2013-10-09
发明人： Nicole Steinmetz , Michael Bruckman
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
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