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公开(公告)号：US20190030193A1
公开(公告)日：2019-01-31
申请号：US16149828
申请日：2018-10-02
发明人： Nicole Steinmetz , Michael Bruckman
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
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公开(公告)号：US11442127B2
公开(公告)日：2022-09-13
申请号：US16603335
申请日：2018-04-06
发明人： Chris Flask , Christian Anderson , Xin Yu , Nicole Steinmetz , Mark A. Griswold , Susann Brady-Kalnay
摘要： The present disclosure provides a method of DDCE-MRF. The method can include: a) introducing two or more contrast agents to a region of interest (ROI) of a subject, the two or more contrast agents having different relaxivities; b) measuring a T1 relaxation time and a T2 relaxation time for locations within the ROI using magnetic resonance fingerprinting (MRF); c) determining, using equations that relate the different relaxivities, the T1 relaxation time, the T2 relaxation time, and concentrations of the two or more contrast agents, the concentrations of the two or more contrast agents for each of the locations within the ROI; and d) producing an image depicting the ROI based, at least in part, on the concentrations of the two or more contrast agents.
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公开(公告)号：US20200339961A1
公开(公告)日：2020-10-29
申请号：US16859400
申请日：2020-04-27
发明人： Jonathan Pokorski , Nicole Steinmetz , Parker Lee
IPC分类号： C12N7/00
摘要： A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
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公开(公告)号：US11946075B2
公开(公告)日：2024-04-02
申请号：US17868144
申请日：2022-07-19
发明人： Jonathan Pokorski , Nicole Steinmetz , Parker Lee
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2770/18023 , C12N2770/18051 , C12N2770/32023 , C12N2770/32051 , C12Y301/27005
摘要： A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
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公开(公告)号：US20230002742A1
公开(公告)日：2023-01-05
申请号：US17851187
申请日：2022-06-28
发明人： Nicole Steinmetz , Daniel Popkin
IPC分类号： C12N7/00 , A61K35/76 , A61K33/243 , A61K31/40 , A61K31/473 , A61K47/46
摘要： A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells.
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公开(公告)号：US20150376578A1
公开(公告)日：2015-12-31
申请号：US14769247
申请日：2014-02-18
发明人： Nicole Steinmetz , Daniel Popkin
IPC分类号： C12N7/00 , A61K31/40 , A61K31/473 , A61K47/46 , A61K33/24
摘要： A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells.
摘要翻译： 描述了非共价加载植物细小核糖核酸病毒的方法。 该方法包括将溶液中的植物微小核糖核酸病毒与摩尔过量的货物分子接触，以将载体分子装载植物微小核糖核酸病毒，然后纯化加载的植物小核糖核酸病毒。 货物分子的实例包括成像剂，抗肿瘤剂和抗病毒剂。 以这种方式制备的装载的小核糖核酸病毒可用于将货物分子递送至细胞。
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公开(公告)号：US20150265729A1
公开(公告)日：2015-09-24
申请号：US14434435
申请日：2013-10-09
发明人： Nicole Steinmetz
CPC分类号： A61K49/1896 , A61K49/1884 , C12N7/00 , C12N2770/00031
摘要： A rod-shaped plant virus having an interior surface and an exterior surface, and at least one imaging agent that is linked to the interior and/or exterior surface is described. The rod-shaped viruses can be combined into larger spherical nanoparticles. A rod-shaped plant virus or spherical nanoparticles including an imaging agent can be used in a method of generating an image of a tissue region of a subject such as a tumor or atherosclerotic tissue by administering the virus particle to the subject and generating an image of the tissue region of the subject to which the virus particle has been distributed.
摘要翻译： 描述了具有内表面和外表面的杆状植物病毒，以及连接到内表面和/或外表面的至少一种成像剂。 杆状病毒可以组合成较大的球形纳米粒子。 包括成像剂的棒状植物病毒或球形纳米粒子可以用于通过向受试者施用病毒颗粒来产生受试者例如肿瘤或动脉粥样硬化组织的组织区域的图像的方法，并产生图像 已分发病毒颗粒的受试者的组织区域。
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公开(公告)号：US20230174952A1
公开(公告)日：2023-06-08
申请号：US17868144
申请日：2022-07-19
发明人： Jonathan Pokorski , Nicole Steinmetz , Parker Lee
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12Y301/27005 , C12N2770/18051 , C12N2770/32023 , C12N2770/18023 , C12N2770/32051
摘要： A method of producing plant virus-like particles includes freeze drying an aqueous solution of plant virus particles to produce a substantially RNA-free plant virus-like particles.
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公开(公告)号：US11371025B2
公开(公告)日：2022-06-28
申请号：US16820073
申请日：2020-03-16
发明人： Nicole Steinmetz , Daniel Popkin
IPC分类号： C12N7/00 , A61K35/76 , A61K33/243 , A61K31/40 , A61K31/473 , A61K47/46
摘要： A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells.
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公开(公告)号：US10590394B2
公开(公告)日：2020-03-17
申请号：US14769247
申请日：2014-02-18
发明人： Nicole Steinmetz , Daniel Popkin
摘要： A method of non-covalently loading a plant picornavirus is described. The method includes contacting a plant picornavirus in solution with a molar excess of a cargo molecule to load the plant picornavirus with the cargo molecule, and then purifying the loaded plant picornavirus. Examples of cargo molecules include imaging agents, antitumor agents, and antiviral agents. Loaded plant picornaviruses prepared in this manner can be used to delivering cargo molecule to cells.
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