公开(公告)号：US09101620B2

公开(公告)日：2015-08-11

申请号：US13501437

申请日：2010-11-02

申请人： Rong Yan ,  Hao Yang ,  Yongxiang Xu

发明人： Rong Yan ,  Hao Yang ,  Yongxiang Xu

IPC分类号： C07D401/04 ,  A61K31/445 ,  A61K31/454

CPC分类号： A61K31/454 ,  C07D401/04

摘要： The present invention provides polymorph of 3-(4-amino-1-oxo-1,3-dihydro-2H-isoindole-2-yl)-piperidine-2,6-dione, and also the preparing methods and pharmaceutical compositions thereof.

摘要翻译： 本发明提供3-（4-氨基-1-氧代-1,3-二氢-2H-异吲哚-2-基） - 哌啶-2,6-二酮的多晶型物，以及其制备方法和药物组合物。

公开(公告)号：US20150215409A1

公开(公告)日：2015-07-30

申请号：US14424667

申请日：2012-09-04

申请人： Likhang Chow ,  Hao Yang ,  Zhen Liu

发明人： Likhang Chow ,  Hao Yang ,  Zhen Liu

IPC分类号： H04L29/08 ,  H04W4/02

CPC分类号： H04L67/18 ,  G06Q30/0259 ,  G06Q30/0261 ,  H04W4/021

摘要： A method, apparatus, computer program product and system are provided for providing mobile services via a scalable location-based publication/subscription comprising a subscription system. In this regard, a method is provided that includes receiving at least one subscription comprising a subscription area and at least one publication comprising a publication location. The method further includes determining a geohash representation of the subscription area and determining whether the at least one publication matches the at least one subscription based at least on the publication location and the geohash representation of the representation of the subscription area. The method further includes causing content associated with the at least one publication to be transmitted in an instance in which the at least one publication matches the at least one subscription.

摘要翻译： 提供了一种方法，装置，计算机程序产品和系统，用于经由包括订阅系统的可扩展的基于位置的发布/订阅来提供移动服务。 在这方面，提供了一种方法，其包括接收包括订阅区域的至少一个订阅和包含发布位置的至少一个发布。 所述方法还包括：确定所述订阅区域的地理位置表示，以及至少基于所述发布位置和所述订阅区域的表示的所述地理位置表示来确定所述至少一个发布是否匹配所述至少一个订阅。 所述方法还包括在所述至少一个出版物与所述至少一个订阅匹配的实例中引起与所述至少一个发布相关联的内容。

公开(公告)号：US08489722B2

公开(公告)日：2013-07-16

申请号：US12625437

申请日：2009-11-24

申请人： Kyriakos Karenos ,  Minkyong Kim ,  Hui Lei ,  Dimitrios Pendarakis ,  Hao Yang ,  Fan Ye

发明人： Kyriakos Karenos ,  Minkyong Kim ,  Hui Lei ,  Dimitrios Pendarakis ,  Hao Yang ,  Fan Ye

IPC分类号： G06F15/173 ,  H04L12/56

CPC分类号： H04L45/00 ,  H04L45/24 ,  H04L45/302

摘要： Techniques for transmitting data according to at least one quality of service requirement. A message path is calculated specifying a sequence of broker computers selected from a network of interconnected broker computers. The message path is statistically estimated to fulfill the at least one quality of service requirement. Quality of service metrics are received about the network of interconnected broker computers. If the message path is determined not to fulfill the quality of service requirement, a new message path is calculated specifying a new sequence of broker computers selected from the network of interconnected broker computers. The new message path is statistically estimated to fulfill the at least one quality of service requirement.

摘要翻译： 根据至少一种服务质量要求传输数据的技术。 计算消息路径，指定从互连代理计算机的网络中选择的代理计算机的序列。 统计估计消息路径以满足至少一个服务质量要求。 收到关于互联经纪电脑网络的服务质量指标。 如果消息路径被确定为不满足服务质量要求，则计算新的消息路径，指定从互连代理计算机的网络中选择的新的代理计算机序列。 统计估计新消息路径以满足至少一个服务质量要求。

公开(公告)号：US20130164856A1

公开(公告)日：2013-06-27

申请号：US13695869

申请日：2011-04-15

申请人： Mais J. Jebrail ,  Hao Yang ,  Aaron R. Wheeler

发明人： Mais J. Jebrail ,  Hao Yang ,  Aaron R. Wheeler

IPC分类号： G01N1/28

CPC分类号： B01L3/502792 ,  B01L3/502753 ,  B01L3/502784 ,  B01L2200/0631 ,  B01L2400/0427 ,  G01N2001/288 ,  G01N2001/4061 ,  H01J49/00 ,  Y10T436/25

摘要： Methods are provided for the preparation of a sample using a digital microfluidic platform and the optional subsequent mass analysis of an extracted analyte. A sample is dried, optionally on a solid phase support, and contacted with digital microfluidic array. An analyte present within the dried sample is extracted into an extraction solvent by electrically addressing the digital microfluidic array to transport a droplet of extraction solvent to the dried sample spot. The extracted sample may be dried and subsequently processed on the digital microfluidic array for derivatization. The digital microfluidic device may further include an integrated microfluidic channel having an output aperture, and the method may further include contacting a droplet containing extracted analyte with the microfluidic channel and applying a suitable electric field for generating nano-electrospray, thereby enabling the device to be directly interfaced with a mass analysis device.

摘要翻译： 提供了使用数字微流体平台制备样品的方法以及提取的分析物的随后的质量分析。 将样品干燥，任选地在固相载体上，并与数字微流体阵列接触。 将干燥样品中存在的分析物通过电解寻址数字微流体阵列将萃取溶剂的液滴输送到干燥的样品点而提取到萃取溶剂中。 提取的样品可以干燥并随后在数字微流体阵列上进行处理以进行衍生。 数字微流体装置还可以包括具有输出孔的集成微流体通道，并且该方法还可以包括使含有提取的分析物的液滴与微流体通道接触并施加合适的电场以产生纳米电喷雾，由此使得该装置能够 直接与质量分析装置连接。

公开(公告)号：US08423619B2

公开(公告)日：2013-04-16

申请号：US12727831

申请日：2010-03-19

申请人： John Christopher Hawkins ,  Francis N. Parr ,  Hao Yang

发明人： John Christopher Hawkins ,  Francis N. Parr ,  Hao Yang

IPC分类号： G06F15/16

CPC分类号： G06F9/542 ,  G06F2209/544

摘要： Message brokering in a consuming broker device of a publish-subscribe system having at least one processor includes: designating in the consuming broker device a first producing broker device as a sole provider of messages having a topic to which the consuming broker device has subscribed; and in response to a determination that a measured livelihood of the first producing broker device is less than a defined threshold, designating with the consuming broker device a second producing broker device as the sole provider of the messages having the topic to the consuming broker device. The second producing broker device has a measured livelihood that is greater than the measured livelihood of the first producing broker device.

摘要翻译： 在具有至少一个处理器的发布订阅系统的消费代理设备中的消息代理包括：在消费代理设备中指定第一生产代理设备作为具有消费代理设备已订阅的主题的消息的唯一提供者; 并且响应于确定第一生产代理设备的测量生计小于定义的阈值，与消费代理设备一起指定作为具有该主题的消息的唯一提供者的第二生产代理设备到消费代理设备。 第二生产经纪人设备的测量生计大于第一生产经纪人设备的测量生计。

公开(公告)号：US20120233295A1

公开(公告)日：2012-09-13

申请号：US13046008

申请日：2011-03-11

申请人： Daniel Bauer ,  Nicholas D. Butler ,  Han Chen ,  Kristijan Dragicevic ,  Luis Garces-Erice ,  Gidon Gershinsky ,  Minkyong Kim ,  Hui Lei ,  David Rushall ,  Marc-Thomas H. Schmidt ,  Konstantin Shagin ,  Hao Yang ,  Liangzhao Zeng

发明人： Daniel Bauer ,  Nicholas D. Butler ,  Han Chen ,  Kristijan Dragicevic ,  Luis Garces-Erice ,  Gidon Gershinsky ,  Minkyong Kim ,  Hui Lei ,  David Rushall ,  Marc-Thomas H. Schmidt ,  Konstantin Shagin ,  Hao Yang ,  Liangzhao Zeng

IPC分类号： G06F15/177

CPC分类号： H04L41/5003 ,  G06F9/5061 ,  H04L41/0806 ,  H04L41/5009 ,  H04L67/2838

摘要： A mechanism for declarative service domain federation uses a declarative approach to both the visibility aspect and the management aspect of service domain federation. Instead of manually exporting services, that is, selecting individual services from source domains to be visible in the target domain, using the present system, a federation architect uses a federation console to specify federation intent. The federation intent may include federation rule, query-based service group, and quality-of-service (QoS) policy. Based on the declared federation intent, a planning engine resolves the individual services based on the group query, generates the service visibility configuration, and creates the necessary service proxies and/or mediation objects to satisfy the goal. At runtime, a service monitor collects the performance metrics of federated services and dynamically adjusts the mediation/proxy configurations to maintain the QoS objectives specified by the federation architect.

摘要翻译： 声明性服务域联合的机制对服务域联合的可见性方面和管理方面使用声明式方法。 代替手动导出服务，即从源域中选择单个服务在目标域中可见，使用本系统，联合架构师使用联合控制台来指定联合意图。 联盟意图可以包括联合规则，基于查询的服务组和服务质量（QoS）策略。 基于声明的联盟意图，计划引擎基于组查询来解析各个服务，生成服务可见性配置，并创建必要的服务代理和/或中介对象以满足目标。 在运行时，服务监视器收集联合服务的性能指标，并动态调整中介/代理配置，以维护联盟架构师指定的QoS目标。

公开(公告)号：US08250185B2

公开(公告)日：2012-08-21

申请号：US12732441

申请日：2010-03-26

申请人： Daniel Bauer ,  Kristijan Dragicevic ,  Luis Garces-Erice ,  Minkyong Kim ,  Hui Lei ,  Hao Yang

发明人： Daniel Bauer ,  Kristijan Dragicevic ,  Luis Garces-Erice ,  Minkyong Kim ,  Hui Lei ,  Hao Yang

IPC分类号： G06F15/177

CPC分类号： H04L67/2838

摘要： A method, device, and computer program product are provided for automatically generating connectivity configuration between domains by a device. A rule is received by the device. The rule is read by the device to determine a first domain invoking a service, a second domain having the service, and connectivity requirements for the first and second domains. A first proxy and a second proxy are automatically determined to fulfill the rule by the device. The first proxy is automatically assigned to the first domain and the second proxy is automatically assigned to the second domain.

摘要翻译： 提供了一种方法，设备和计算机程序产品，用于通过设备自动生成域之间的连接配置。 设备接收到一条规则。 该规则由设备读取以确定调用服务的第一域，具有该服务的第二域以及第一域和第二域的连接性要求。 自动确定第一代理和第二代理以实现设备的规则。 第一个代理自动分配给第一个域，第二个代理自动分配给第二个域。

公开(公告)号：US08112416B2

公开(公告)日：2012-02-07

申请号：US11754068

申请日：2007-05-25

申请人： Zhen Liu ,  Srinivasan Parthasarathy ,  Anand Ranganathan ,  Hao Yang

发明人： Zhen Liu ,  Srinivasan Parthasarathy ,  Anand Ranganathan ,  Hao Yang

IPC分类号： G06F7/00

CPC分类号： G06F17/2785 ,  G06F17/30699

摘要： A semantic publish-subscribe system, including: a plurality of subscribers; a plurality of publishers; and a server that receives and stores subscriptions that are described in web ontology language (OWL) graph patterns from the plurality of subscribers and that receives events that are described in semantic graphs formed by OWL assertions from the plurality of publishers, wherein when the server receives an event from a publisher, the server expands the OWL assertions of the event using a reasoner to produce an expanded event, the server matches the expanded event to a subscription, and then, the server notifies a subscriber whose interest matches the event.

摘要翻译： 一种语义发布订阅系统，包括：多个用户; 多个出版商; 以及服务器，其接收并存储来自所述多个订户的以网络本体语言（OWL）图形模式描述的订阅，并且接收在所述多个发布者中由OWL断言形成的语义图中描述的事件，其中，当所述服务器接收到 来自发布者的事件，服务器使用推理器来扩展事件的OWL断言，以生成扩展事件，服务器将展开的事件与订阅进行匹配，然后，服务器通知其兴趣与事件匹配的用户。

公开(公告)号：US08037023B2

公开(公告)日：2011-10-11

申请号：US12135489

申请日：2008-06-09

申请人： Zhen Liu ,  Honghui Xia ,  Hao Yang ,  Fan Ye

发明人： Zhen Liu ,  Honghui Xia ,  Hao Yang ,  Fan Ye

IPC分类号： G06F17/30

CPC分类号： G06F17/30578 ,  Y10S707/99932 ,  Y10S707/99953 ,  Y10S707/99955

摘要： Methods and systems are provided for optimally trading off replication overhead and consistency levels in distributed data replication where nodes are organized in a hierarchy. The root node has the original data that need to be replicated at all other nodes, and the replicated copies have a freshness threshold that must be satisfied. The data are propagated through periodic updates in the hierarchy. Each node periodically sends data to its child nodes. Given the freshness threshold, an algorithm and its distributed protocol can determine the optimal update period for each link of the hierarchy such that the freshness threshold is satisfied for every node and the overall replication overhead is minimized. The systems and methods can be used in any scenario where replicated data have consistency requirements, such as in a replicate overlay assisted resource discovery system.

摘要翻译： 提供了方法和系统，用于最佳地折中分布式数据复制中的复制开销和一致性级别，其中节点被组织在层次结构中。 根节点具有需要在所有其他节点进行复制的原始数据，并且复制副本具有必须满足的新鲜度阈值。 数据通过层次结构中的定期更新进行传播。 每个节点周期性地向其子节点发送数据。 给定新鲜度阈值，算法及其分布式协议可以确定层次结构的每个链路的最佳更新周期，使得每个节点满足新鲜度阈值，并将整体复制开销最小化。 系统和方法可以在复制数据具有一致性要求的任何情况下使用，例如在复制覆盖辅助资源发现系统中。

公开(公告)号：US09916363B2

公开(公告)日：2018-03-13

申请号：US14112090

申请日：2011-04-19

申请人： Jilei Tian ,  Shaowei Jiang ,  Xinxing Yang ,  Dong Liu ,  Hao Yang

发明人： Jilei Tian ,  Shaowei Jiang ,  Xinxing Yang ,  Dong Liu ,  Hao Yang

IPC分类号： G06F7/00 ,  G06F17/30

CPC分类号： G06F17/3053 ,  G06F17/30522 ,  G06F17/3064 ,  G06F17/30648 ,  G06F17/30867

摘要： An approach is provided for diversifying recommendation results. A diversification manager determines one or more recommendation scores associated with one or more items. The one or more recommendation scores are for determining a sort order of the one or more items. The diversification manager then determines similarity information associated with the one or more items, and processes and/or facilitates a processing of the similarity information to cause, at least in part, an adjustment of the one or more recommendation scores, the sort order, or a combination thereof.