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11.发明申请2-Oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效可用于治疗高增殖性，血管生成和炎性疾病的2-氧代-1,3,5-全氢三氮杂衍生物公开(公告)号：US20050032798A1
公开(公告)日：2005-02-10
申请号：US10788405
申请日：2004-03-01
申请人： Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人： Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号： A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译： 本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。
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12.发明授权Substituted pyrimidine derivatives useful in the treatment of cancer and other disorders 失效可用于治疗癌症和其他疾病的取代嘧啶衍生物公开(公告)号：US08580798B2
公开(公告)日：2013-11-12
申请号：US12158524
申请日：2006-12-20
申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
发明人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
IPC分类号： C07D401/12 , A61K31/506
CPC分类号： C07D401/12
摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.
摘要翻译： 式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗 增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。
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公开(公告)号：US20090253762A1
公开(公告)日：2009-10-08
申请号：US12206721
申请日：2008-09-08
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , C07D277/82 , C07D413/02 , A61K31/416 , A61K31/423 , C07D405/02
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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14.发明申请公开(公告)号：US20080214545A1
公开(公告)日：2008-09-04
申请号：US11579093
申请日：2005-05-02
申请人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号： A61K31/5377 , C07D401/12 , C07D413/14 , A61P35/02 , A61P35/00 , A61K31/4439
CPC分类号： C07D401/12 , C07D405/14
摘要： The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译： 本发明涉及式（I）化合物，含有它们的药物组合物和使用式（I）化合物治疗癌症的方法。
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公开(公告)号：US07091228B2
公开(公告)日：2006-08-15
申请号：US10839833
申请日：2004-05-06
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , A61K31/426 , C07D277/82 , C07D277/42
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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16.发明授权公开(公告)号：US08207166B2
公开(公告)日：2012-06-26
申请号：US12941841
申请日：2010-11-08
申请人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Mokdad
发明人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Mokdad
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/454 , A61K31/497
CPC分类号： C07D401/12 , C07D405/14
摘要： The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译： 本发明涉及式（I）化合物，含有它们的药物组合物和使用式（I）化合物治疗癌症的方法。
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17.发明授权公开(公告)号：US07838524B2
公开(公告)日：2010-11-23
申请号：US11579093
申请日：2005-05-02
申请人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
发明人： Wendy Lee , Gaetan Ladouceur , Jacques Dumas , Roger Smith , Shihong Ying , Gan Wang , Zhi Chen , Qingjie Liu , Holia Hatoum Mokdad
IPC分类号： A61K31/4439 , A61K31/5377 , A61K31/497 , A61K31/454 , C07D401/14 , C07D413/14
CPC分类号： C07D401/12 , C07D405/14
摘要： The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译： 本发明涉及式（I）化合物，含有它们的药物组合物和使用式（I）化合物治疗癌症的方法。
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18.发明申请SUBSTITUTED PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 失效用于治疗癌症和其他疾病的替代吡嗪衍生物公开(公告)号：US20100081812A1
公开(公告)日：2010-04-01
申请号：US12158524
申请日：2006-12-20
申请人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
发明人： Roger Smith , Jacques Dumas , Gan Wang , Wendy Lee , Karl Miranda
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： Substituted pyrimidine derivatives of formula (I), salts, metabolites, prodrugs and diastereoisomeric forms (both isolated stereoisomers and mixtures of stereoisomers) thereof (wherein A=pyrimidine) pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with other active ingredients, e.g., cytotoxic therapies.
摘要翻译： 式（I）的取代的嘧啶衍生物，其盐，代谢物，前药和非对映异构体形式（分离的立体异构体和立体异构体的混合物）（其中A =嘧啶）含有这些化合物的药物组合物以及这些化合物或组合物用于治疗 增殖和血管生成障碍，作为唯一的药剂或与其它活性成分组合，例如细胞毒性疗法。
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公开(公告)号：US20060194859A1
公开(公告)日：2006-08-31
申请号：US11341197
申请日：2006-01-27
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/5377 , A61K31/4184 , C07D235/30
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
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20.发明申请公开(公告)号：US20050256167A1
公开(公告)日：2005-11-17
申请号：US11133751
申请日：2005-05-20
申请人： Roger Smith , Stephen O'Connor , Stephan-Nicholas Wirtz , Wai Wong , Soongyu Choi , Harold Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
发明人： Roger Smith , Stephen O'Connor , Stephan-Nicholas Wirtz , Wai Wong , Soongyu Choi , Harold Kluender , Ning Su , Gan Wang , Furahi Achebe , Shihong Ying
IPC分类号： A61K31/4164 , A61K31/4196 , A61K31/42 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/551 , A61K45/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/28 , A61P25/30 , A61P35/00 , C07D233/90 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/04 , C07D417/04 , C07D417/08 , C07D417/14 , A61K31/4172 , C07D43/02
CPC分类号： C07D401/06 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/06 , C07D409/14
摘要： This invention relates to substituted imidazole derivatives which have been found to suppress appetite and induce weight loss. The invention also provides methods for synthesis of the compounds, pharmaceutical compositions comprising the compounds, and methods of using such compositions for inducing weight loss and treating obesity and obesity-related disorders.
摘要翻译： 本发明涉及已被发现抑制食欲并引起体重减轻的取代的咪唑衍生物。 本发明还提供了合成化合物的方法，包含该化合物的药物组合物，以及使用这些组合物诱导体重减轻和治疗肥胖症和肥胖相关疾病的方法。
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