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1.2-Oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效
标题翻译: 可用于治疗高增殖性,血管生成和炎性疾病的2-氧代-1,3,5-全氢三氮杂衍生物公开(公告)号:US20050032798A1
公开(公告)日:2005-02-10
申请号:US10788405
申请日:2004-03-01
申请人: Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人: Stephen Boyer , Jacques Dumas , Barton Phillips , William Scott , Roger Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号: A61K31/335 , A61K31/416 , A61K31/4184 , A61K31/4192 , A61K31/423 , A61K31/428 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/444 , A61K31/4709 , A61K31/498 , A61K31/53 , A61K31/538 , A61K31/5415 , A61P35/00 , C07D213/68 , C07D213/79 , C07D213/84 , C07D251/02 , C07D333/66 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
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2.2-oxo-1,3,5-perhydrotriazapine derivatives useful in the treatment of hyper-proliferative, angiogenesis, and inflammatory disorders 失效
标题翻译: 可用于治疗高增殖性,血管生成和炎症性疾病的2-氧代-1,3,5-三氢三氮杂衍生物公开(公告)号:US07928227B2
公开(公告)日:2011-04-19
申请号:US10788405
申请日:2004-03-01
申请人: Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
发明人: Stephen Boyer , Jacques Dumas , Barton Phillips , William J. Scott , Roger A. Smith , Jianqing Chen , Benjamin Jones , Gan Wang
IPC分类号: C07D251/08 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/53 , A61P19/02
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
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3.Fused tricyclic heterocycles useful for treating hyper-proliferative disorders 失效
标题翻译: 用于治疗高增殖性疾病的融合的三环杂环公开(公告)号:US20060287387A1
公开(公告)日:2006-12-21
申请号:US11512032
申请日:2006-08-28
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilhelm , Qian Zhao
IPC分类号: A61K31/381 , A61K31/343
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及下式的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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4.Fused tricyclic heterocycles useful for treating hyper-proliferative disoroders 失效
标题翻译: 用于治疗超增殖解调器的融合的三环杂环公开(公告)号:US20050165042A1
公开(公告)日:2005-07-28
申请号:US10501690
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilheim , Qian Zhao
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Phillips , Scott Wilheim , Qian Zhao
IPC分类号: A61K31/343 , A61K31/381 , A61K31/4741 , A61K31/4743 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D407/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
CPC分类号: C07D407/06 , C07D307/92 , C07D307/93 , C07D333/74 , C07D405/06 , C07D409/06 , C07D413/06 , C07D491/04 , C07D493/04
摘要: This invention relates to a novel fused tricyclic heterocycle of the formula (Ia, Ib) and its use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及式(Ia,Ib)的新型稠合三环杂环及其用于治疗高增殖性疾病的用途。
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5.Benzofuran and benzothiophene derivatives useful in the treatmint of hyper-proliferative disorders 失效
标题翻译: 苯并呋喃和苯并噻吩衍生物可用于高增殖性疾病的治疗公开(公告)号:US20050139814A1
公开(公告)日:2005-06-30
申请号:US10501689
申请日:2003-02-21
申请人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
发明人: Chengzhi Zhang , Michael Burke , Zhi Chen , Jacques Dumas , Dongping Fan , Jianmei Fan , Holia Hatoum-Mokdad , Benjamin Jones , Gaetan Ladouceur , Wendy Lee , Barton Philiips
IPC分类号: A61K31/343 , A61K31/353 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/422 , A61K31/427 , A61K31/4355 , A61K31/443 , A61K31/4436 , A61K31/455 , A61K31/497 , A61P13/08 , A61P13/10 , A61P35/00 , A61P35/02 , A61P35/04 , B66F3/36 , C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/06 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D491/048 , C07D493/04
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general table formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及通用表配方的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
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6.Pyrrolotriazine Derivatives Useful For Treating Hyper-Proliferative Disorders And Diseases Associated With Angiogenesis 有权
标题翻译: 用于治疗与血管发生相关的超增殖性疾病和疾病的吡咯嗪衍生物公开(公告)号:US20070208013A1
公开(公告)日:2007-09-06
申请号:US11596913
申请日:2005-06-03
申请人: Julie Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea Mcclure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold Kluender
发明人: Julie Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea Mcclure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold Kluender
IPC分类号: A61K31/541 , A61K31/5377 , A61K31/53 , C07D487/04
CPC分类号: C07D491/113 , C07D487/04
摘要: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译: 本发明涉及新颖的吡唑并三嗪化合物,含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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7.Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis 有权
标题翻译: 可用于治疗高增殖性疾病和与血管发生相关的疾病的吡咯嗪衍生物公开(公告)号:US07563791B2
公开(公告)日:2009-07-21
申请号:US11596913
申请日:2005-06-03
申请人: Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C. E. Kluender
发明人: Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C. E. Kluender
IPC分类号: C07D487/04 , C07D417/02 , C07D413/02 , A61K31/53 , A61K35/00
CPC分类号: C07D491/113 , C07D487/04
摘要: This invention relates to novel pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译: 本发明涉及新颖的吡唑并三嗪化合物,含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性障碍和疾病的用途。
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8.PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS 有权
标题翻译: 用于治疗与促血细胞生成相关的高血压疾病和疾病的吡咯烷酮衍生物公开(公告)号:US20100075958A1
公开(公告)日:2010-03-25
申请号:US12506033
申请日:2009-07-20
申请人: Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C.E. Kluender
发明人: Julie A. Dixon , Catherine Brennan , Karl Miranda , Brent Chandler , Barton Phillips , Jianmei Fan , Michael Brands , Andrea McClure , Benjamin Jones , Wenlang Fu , Donald Bierer , Steven Magnuson , Harold C.E. Kluender
IPC分类号: A61K31/53 , C07D471/04 , A61K31/5377 , A61P35/00
CPC分类号: C07D491/113 , C07D487/04
摘要: This invention relates to pyrrozolotriazine compounds, pharmaceutical compositions containing such compounds and the use of those compounds and compositions for the prevention and/or treatment of hyper-proliferative disorders and diseases associated with angiogenesis.
摘要翻译: 本发明涉及吡咯并三嗪化合物,含有这些化合物的药物组合物以及这些化合物和组合物用于预防和/或治疗与血管发生相关的高增殖性病症和疾病的用途。
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公开(公告)号:US20110011888A2
公开(公告)日:2011-01-20
申请号:US12205762
申请日:2008-09-05
申请人: Russell Beavis , Benjamin Jones , John Kerwin , Larry Gray , Casey Manning , Felix Winkler
发明人: Russell Beavis , Benjamin Jones , John Kerwin , Larry Gray , Casey Manning , Felix Winkler
摘要: A product dispensing system includes a flow control device configured to regulate a first ingredient. A pump module is configured to be coupled to a supply of a second ingredient. A controller is configured to provide a first control signal to the flow control device for controlling the supply of a first quantity of the first ingredient based upon, at least in part, a predetermined recipe. The controller is further configured to provide a second control signal to the pump module for controlling the supply of a first quantity of the second ingredient based upon, at least in part, the predetermined recipe.
摘要翻译: 产品分配系统包括配置成调节第一成分的流量控制装置。 泵模块被配置为联接到第二成分的供应。 控制器被配置为向流量控制装置提供第一控制信号,以至少部分地基于预定的配方来控制第一数量的第一成分的供应。 控制器还被配置为向泵模块提供第二控制信号,用于至少部分地基于预定配方来控制第一数量的第二成分的供应。
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公开(公告)号:US20090291938A1
公开(公告)日:2009-11-26
申请号:US12274213
申请日:2008-11-19
申请人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
发明人: Sheldon X. Cao , Victoria Feher , Takashi Ichikawa , Benjamin Jones , Stephen W. Kaldor , Andre A. Kiryanov , Betty Lam , Yan Liu , Christopher McBride , Srinivasa Reddy Natala , Zhe Nie , Jeffrey A. Stafford
IPC分类号: A61K31/551 , C07D487/04
CPC分类号: C07D487/04
摘要: Compounds of the following formula are provided for use with kinases: wherein the variables are as defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
摘要翻译: 提供下式的化合物用于激酶:其中变量如本文所定义。 还提供了包含这些化合物的药物组合物,试剂盒和制品; 用于制备化合物的方法和中间体; 以及使用所述化合物的方法。
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