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11.发明申请Method for inducing cell lysis with immunogenic portions of NY-ESO-1 protein 有权用NY-ESO-1蛋白的免疫原性部分诱导细胞裂解的方法公开(公告)号：US20110182944A1
公开(公告)日：2011-07-28
申请号：US12930522
申请日：2011-01-10
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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12.发明授权Isolated nucleic acid molecules which encode immunogenic portions of NY-ESO-1 protein 有权编码NY-ESO-1蛋白免疫原性部分的分离的核酸分子公开(公告)号：US07888100B2
公开(公告)日：2011-02-15
申请号：US11499547
申请日：2006-08-04
申请人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
发明人： Alexander Knuth , Elke Jäger , Yao-tseng Chen , Matthew Scanlan , Ali Gure , Gerd Ritter , Lloyd J. Old , Jan W. Drijfhout
IPC分类号： C07H21/04 , C12N5/10 , C12N15/861 , C12N15/70
CPC分类号： C07K14/4748 , A61K38/00 , Y10S435/81
摘要： The invention relates to peptides which bind to MHC Class I and to MHC Class II molecules. These peptides are useful in different therapeutic and diagnostic contexts.
摘要翻译： 本发明涉及结合MHC I类和MHC II类分子的肽。 这些肽可用于不同的治疗和诊断情境。
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13.发明授权Method for determining status of a cancerous condition by determining antibodies to NY-ESO-1 in a patient sample 有权通过在患者样品中测定NY-ESO-1的抗体来确定癌症状态的方法公开(公告)号：US06251603B1
公开(公告)日：2001-06-26
申请号：US09359503
申请日：1999-07-23
申请人： Elke Jäger , Elisabeth Stockert , Lloyd J. Old , Alexander Knuth
发明人： Elke Jäger , Elisabeth Stockert , Lloyd J. Old , Alexander Knuth
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/4748 , C07K16/18 , G01N33/574
摘要： The invention relates to methods for determining tumor status by determining antibodies specific to NY-ESO-1 in patient samples. One can determine whether a cancerous condition is progressing, regressing, or remaining stable by determining antibodies against NY-ESO-1 in a patient sample, and comparing the value obtained to a prior value. When the tumor in question expresses NY-ESO-1, a change in this value is indicative of a change in status of the cancerous condition.
摘要翻译： 本发明涉及通过测定患者样品中NY-ESO-1特异性的抗体来确定肿瘤状态的方法。 可以通过确定患者样品中针对NY-ESO-1的抗体，并将获得的值与先前值进行比较来确定癌症状况是否进展，回归或保持稳定。 当所讨论的肿瘤表达NY-ESO-1时，该值的变化表示癌症状态的变化。
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公开(公告)号：US20100330075A1
公开(公告)日：2010-12-30
申请号：US12530764
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Alfred Zippelius , Dirk Jaeger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Goebels
发明人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Alfred Zippelius , Dirk Jaeger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Goebels
IPC分类号： A61K39/395 , C12P21/04 , C12N9/96 , C12N5/10 , C12N15/63 , G01N33/53 , C07K14/705 , C07K7/06 , C07K7/08 , C07K5/10 , C07K5/08 , C07K16/30 , C07H21/04 , A61P35/00 , A61P35/02
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.
摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。
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公开(公告)号：US20110123447A1
公开(公告)日：2011-05-26
申请号：US12450101
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Roger Nitsch , Holger Moch , Norbert Goebels , Dirk Jaeger , Alfred Zippelius , Alexander Knuth
发明人： Christoph Esslinger , Sandra Kuenzle , Irene Abela , Roger Nitsch , Holger Moch , Norbert Goebels , Dirk Jaeger , Alfred Zippelius , Alexander Knuth
IPC分类号： A61K39/395 , G01N33/53 , C12P21/00 , C07K16/18 , C07K14/47 , C07H21/00 , C12N15/63 , C12N5/10 , C12N9/96 , A61P35/00 , A61K49/00
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel tumor-specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigens and that are obtained from a tumor patient who shows at least partial clinical response or is symptom-free. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of tumors are described.
摘要翻译： 提供了新的肿瘤特异性结合分子，特别是人抗体以及识别肿瘤相关抗原的片段，衍生物和变体，并且其从显示至少部分临床反应或无症状的肿瘤患者获得。 此外，描述了包含这样的结合分子，抗体及其模拟物的药物组合物以及筛选新结合分子的方法，其可以是或可以不是抗体以及肿瘤治疗中的靶标。
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公开(公告)号：US08519106B2
公开(公告)日：2013-08-27
申请号：US12530764
申请日：2008-03-13
申请人： Christoph Esslinger , Sandra Künzle , Irene Abela , Alfred Zippelius , Dirk Jäger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Göbels
发明人： Christoph Esslinger , Sandra Künzle , Irene Abela , Alfred Zippelius , Dirk Jäger , Alexander Knuth , Roger Nitsch , Holger Moch , Norbert Göbels
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.
摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。
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17.发明授权Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per SE, and uses thereof 有权编码癌症相关抗原的分离的核酸分子，每个SE的抗原及其用途公开(公告)号：US07795409B2
公开(公告)日：2010-09-14
申请号：US12011953
申请日：2008-01-30
申请人： Dirk Jager , Elisabeth Stockert , Barry C. Picker, legal representative , Matthew Scanlan , Cynthia H. Scanlan, legal representative , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
IPC分类号： C07H21/02
CPC分类号： C07K14/47 , C07K14/4748
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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18.发明授权公开(公告)号：US07132507B2
公开(公告)日：2006-11-07
申请号：US10153318
申请日：2002-05-21
申请人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
发明人： Dirk Jager , Elizabeth Stockert , Matthew Scanlan , Ali Gure , Elke Jager , Alexander Knuth , Lloyd Old , Yao-Tseng Chen
CPC分类号： C07K14/4748 , A61K39/00 , C12N2799/022 , C12N2799/023 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to isolated, cancer associated antigens, nucleic acid molecules, and various uses thereof.
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19.发明授权Isolated nucleic acid molecule encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US06830924B1
公开(公告)日：2004-12-14
申请号：US09270437
申请日：1999-03-16
申请人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
发明人： Yao-Tseng Chen , Ali Gure , Solam Tsang , Elisabeth Stockert , Elke Jager , Alexander Knuth , Lloyd J. Old
IPC分类号： C12N1563
CPC分类号： C07K14/4748 , A61K2039/505
摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。 本发明还涉及关于已知分子KOC-1的观察。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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20.发明申请Isolated nucleic acid molecules encoding cancer associated antigens, the antigens per se, and uses thereof 失效编码癌相关抗原的分离的核酸分子，抗原本身及其用途公开(公告)号：US20100278850A1
公开(公告)日：2010-11-04
申请号：US12589647
申请日：2009-10-27
申请人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
发明人： Dirk Jager , Elisabeth Stockert , Matthew Scanlan , Alexander Knuth , Lloyd Old , Ali Gure , Yao-Tseng Chen , Elke Jager
IPC分类号： A61K39/00 , C07K14/435 , A61P35/00 , C07K7/06 , C07K7/08
CPC分类号： C07K14/47
摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.
摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。
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