公开(公告)号：US20100330075A1

公开(公告)日：2010-12-30

申请号：US12530764

申请日：2008-03-13

申请人： Christoph Esslinger ,  Sandra Kuenzle ,  Irene Abela ,  Alfred Zippelius ,  Dirk Jaeger ,  Alexander Knuth ,  Roger Nitsch ,  Holger Moch ,  Norbert Goebels

发明人： Christoph Esslinger ,  Sandra Kuenzle ,  Irene Abela ,  Alfred Zippelius ,  Dirk Jaeger ,  Alexander Knuth ,  Roger Nitsch ,  Holger Moch ,  Norbert Goebels

IPC分类号： A61K39/395 ,  C12P21/04 ,  C12N9/96 ,  C12N5/10 ,  C12N15/63 ,  G01N33/53 ,  C07K14/705 ,  C07K7/06 ,  C07K7/08 ,  C07K5/10 ,  C07K5/08 ,  C07K16/30 ,  C07H21/04 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K49/0002 ,  C07K16/3053 ,  C07K2317/21

摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.

摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。

公开(公告)号：US20110123447A1

公开(公告)日：2011-05-26

申请号：US12450101

申请日：2008-03-13

申请人： Christoph Esslinger ,  Sandra Kuenzle ,  Irene Abela ,  Roger Nitsch ,  Holger Moch ,  Norbert Goebels ,  Dirk Jaeger ,  Alfred Zippelius ,  Alexander Knuth

发明人： Christoph Esslinger ,  Sandra Kuenzle ,  Irene Abela ,  Roger Nitsch ,  Holger Moch ,  Norbert Goebels ,  Dirk Jaeger ,  Alfred Zippelius ,  Alexander Knuth

IPC分类号： A61K39/395 ,  G01N33/53 ,  C12P21/00 ,  C07K16/18 ,  C07K14/47 ,  C07H21/00 ,  C12N15/63 ,  C12N5/10 ,  C12N9/96 ,  A61P35/00 ,  A61K49/00

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K49/0002 ,  C07K16/3053 ,  C07K2317/21

摘要： Provided are novel tumor-specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigens and that are obtained from a tumor patient who shows at least partial clinical response or is symptom-free. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of tumors are described.

摘要翻译： 提供了新的肿瘤特异性结合分子，特别是人抗体以及识别肿瘤相关抗原的片段，衍生物和变体，并且其从显示至少部分临床反应或无症状的肿瘤患者获得。 此外，描述了包含这样的结合分子，抗体及其模拟物的药物组合物以及筛选新结合分子的方法，其可以是或可以不是抗体以及肿瘤治疗中的靶标。

公开(公告)号：US08519106B2

公开(公告)日：2013-08-27

申请号：US12530764

申请日：2008-03-13

申请人： Christoph Esslinger ,  Sandra Künzle ,  Irene Abela ,  Alfred Zippelius ,  Dirk Jäger ,  Alexander Knuth ,  Roger Nitsch ,  Holger Moch ,  Norbert Göbels

发明人： Christoph Esslinger ,  Sandra Künzle ,  Irene Abela ,  Alfred Zippelius ,  Dirk Jäger ,  Alexander Knuth ,  Roger Nitsch ,  Holger Moch ,  Norbert Göbels

IPC分类号： C12P21/08

CPC分类号： C07K16/30 ,  A61K45/06 ,  A61K49/0002 ,  C07K16/3053 ,  C07K2317/21

摘要： Provided are novel human tumor-specific antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigen NY-ESO-1. In addition, pharmaceutical compositions comprising such antibodies and mimics thereof in the treatment of tumors are described.

摘要翻译： 提供了新的人肿瘤特异性抗体以及识别肿瘤相关抗原NY-ESO-1的片段，衍生物和变体。 此外，描述了包含这种抗体的药物组合物及其在治疗肿瘤中的模拟物。

公开(公告)号：US20100202968A1

公开(公告)日：2010-08-12

申请号：US12522031

申请日：2008-01-07

申请人： Roger Nitsch ,  Christoph Hock ,  Christoph Esslinger ,  Marlen Knobloch ,  Kathrin Tissot ,  Jan Grimm

发明人： Roger Nitsch ,  Christoph Hock ,  Christoph Esslinger ,  Marlen Knobloch ,  Kathrin Tissot ,  Jan Grimm

IPC分类号： A61K49/00 ,  G01N33/50 ,  C07K16/00 ,  C07H21/00 ,  C12N15/74 ,  C12N5/10 ,  C12P21/02 ,  A61K31/7088 ,  A61K35/12 ,  A61K39/395 ,  A61K39/00 ,  A61P25/28

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/77

摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.

摘要翻译： 提供了新型特异性结合分子，特别是人抗体以及其识别疾病相关蛋白的新表型的片段，衍生物和变体，其衍生自天然内源性蛋白质，但是在变体形式和/或出口的患者体内普遍存在 的正常生理环境。 此外，描述了包含这样的结合分子的药物组合物，其抗体及其模拟物以及筛选新结合分子的方法，其可以是或可以不是抗体以及治疗神经疾病如阿尔茨海默病的靶标。

公开(公告)号：US08906367B2

公开(公告)日：2014-12-09

申请号：US12522031

申请日：2008-01-07

申请人： Roger Nitsch ,  Christoph Hock ,  Christoph Esslinger ,  Marlen Knobloch ,  Kathrin Tissot ,  Jan Grimm

发明人： Roger Nitsch ,  Christoph Hock ,  Christoph Esslinger ,  Marlen Knobloch ,  Kathrin Tissot ,  Jan Grimm

IPC分类号： A61K39/395 ,  C07K16/00 ,  C12N15/00 ,  C12P21/00 ,  C07K16/18 ,  A61K39/00

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/77

摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.

摘要翻译： 提供了新型特异性结合分子，特别是人抗体以及其识别疾病相关蛋白的新表型的片段，衍生物和变体，其衍生自天然内源性蛋白质，但是在变体形式和/或出口的患者体内普遍存在 的正常生理环境。 此外，描述了包含这样的结合分子的药物组合物，其抗体及其模拟物以及筛选新结合分子的方法，其可以是或可以不是抗体以及治疗神经疾病如阿尔茨海默病的靶标。

公开(公告)号：US09370531B2

公开(公告)日：2016-06-21

申请号：US12733437

申请日：2008-09-01

申请人： Karsten Henco ,  Roger Nitsch ,  Jan Grimm ,  Anja Zeller ,  Marcel Maier

发明人： Karsten Henco ,  Roger Nitsch ,  Jan Grimm ,  Anja Zeller ,  Marcel Maier

IPC分类号： A61K45/00 ,  A61K39/00 ,  C12N15/117 ,  A61K31/7088 ,  A61K39/39

CPC分类号： A61K39/0007 ,  A61K31/7088 ,  A61K39/39 ,  A61K2039/53 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2039/575 ,  C12N15/117 ,  G01N33/6896 ,  G01N2333/4709 ,  Y02A50/41

摘要： A treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are also described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.

摘要翻译： 通过增强或维持针对主要针对存在于所述蛋白质或蛋白质复合物的致病形式的病理蛋白聚集体或新表位的抗体应答来提供治疗阿尔茨海默氏病和其它涉及蛋白质错误折叠或聚集的疾病。 此外，还描述了将离体刺激的抗原选择的外周血淋巴细胞移植到同源供体中的治疗方法。

公开(公告)号：US09283271B2

公开(公告)日：2016-03-15

申请号：US13992840

申请日：2011-12-19

申请人： Fabio Montrasio ,  Maria Grazia Barenco Montrasio ,  Jan Grimm ,  Roger Nitsch ,  Christoph Hock ,  Marcel Maier

发明人： Fabio Montrasio ,  Maria Grazia Barenco Montrasio ,  Jan Grimm ,  Roger Nitsch ,  Christoph Hock ,  Marcel Maier

IPC分类号： A61K39/395 ,  A61K39/00 ,  C07K14/435 ,  C07K16/40 ,  C12N9/02 ,  A61K45/06 ,  A61K47/48 ,  A61K49/08 ,  A61K51/10 ,  G01N33/573

CPC分类号： C07K16/40 ,  A61K39/0005 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6871 ,  A61K49/085 ,  A61K51/10 ,  A61K2039/505 ,  C07K14/435 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C12N9/0089 ,  G01N33/573 ,  G01N33/577 ,  G01N33/6893 ,  G01N2333/90283 ,  G01N2800/28 ,  G01N2800/285

摘要： Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.

摘要翻译： 提供新型人铜 - 锌超氧化物歧化酶，也称为超氧化物歧化酶1或SOD1，特异性抗体以及其片段，衍生物和变体以及与之相关的方法。 还公开了与SOD1特异性抗体相关的测定，试剂盒和固体支持物。 抗体，免疫球蛋白链以及其结合片段，衍生物和变体可分别用于SOD1靶向免疫治疗和诊断的药物和诊断组合物中。

公开(公告)号：US20140301945A1

公开(公告)日：2014-10-09

申请号：US13992840

申请日：2011-12-19

申请人： Fabio Montrasio ,  Maria Grazia Barenco Montrasio ,  Jan Grimm ,  Roger Nitsch ,  Christoph Hock ,  Tobias Welt ,  Jordan McAfoose ,  Marcel Maier

发明人： Fabio Montrasio ,  Maria Grazia Barenco Montrasio ,  Jan Grimm ,  Roger Nitsch ,  Christoph Hock ,  Tobias Welt ,  Jordan McAfoose ,  Marcel Maier

IPC分类号： A61K39/395 ,  A61K49/08 ,  G01N33/573 ,  A61K45/06 ,  A61K47/48 ,  C12N9/02 ,  A61K51/10 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K39/0005 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6871 ,  A61K49/085 ,  A61K51/10 ,  A61K2039/505 ,  C07K14/435 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  C12N9/0089 ,  G01N33/573 ,  G01N33/577 ,  G01N33/6893 ,  G01N2333/90283 ,  G01N2800/28 ,  G01N2800/285

摘要： Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.

摘要翻译： 提供新型人铜 - 锌超氧化物歧化酶，也称为超氧化物歧化酶1或SOD1，特异性抗体以及其片段，衍生物和变体以及与之相关的方法。 还公开了与SOD1特异性抗体相关的测定，试剂盒和固体支持物。 抗体，免疫球蛋白链以及其结合片段，衍生物和变体可分别用于SOD1靶向免疫治疗和诊断的药物和诊断组合物中。

公开(公告)号：US20090023145A1

公开(公告)日：2009-01-22

申请号：US11979234

申请日：2007-10-31

申请人： Roger Nitsch ,  John Growdon

发明人： Roger Nitsch ,  John Growdon

IPC分类号： C12Q1/68

CPC分类号： G01N33/6896 ,  G01N2333/8139 ,  G01N2800/2821

摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.

摘要翻译： 一种用于诊断或预测受试者中的阿尔茨海默病的方法，或确定受试者是否处于发展中的阿尔茨海默氏病的风险增加的方法，其包括：确定转录产物和/或其他疾病的水平或活性，或所述水平和所述活性 （i）半胱氨酸蛋白酶抑制剂C基因或（ii）来自所述受试者的样品中半胱氨酸蛋白酶抑制剂C基因的多态性变体的翻译产物; 以及将所述转录产物和/或所述翻译产物的所述水平或所述活性，或所述水平和所述活性两者进行比较，以代表已知疾病或健康状况的参考值，由此诊断或预测所述受试者的阿尔茨海默氏病，或 确定所述受试者是否处于发展为阿尔茨海默氏病的风险增加。

公开(公告)号：US20080188435A1

公开(公告)日：2008-08-07

申请号：US12003851

申请日：2008-01-02

申请人： Roger Nitsch ,  Christoph Hock ,  Uwe Otten

发明人： Roger Nitsch ,  Christoph Hock ,  Uwe Otten

IPC分类号： A61K31/70 ,  C12Q1/02 ,  C12Q1/68 ,  A61P25/00 ,  G01N33/567

CPC分类号： G01N33/6896 ,  G01N2333/4709 ,  G01N2333/475 ,  G01N2800/304

摘要： The invention relates to a method for diagnosing or prognosing depression, in particular major depression, in a subject, or determining whether a subject is at increased risk of developing depression, in particular major depression, comprising: determining a level, or an activity, or both said level and said activity, of neurotrophin 3 and/or of a transcription product of a gene coding for neurotrophin 3 in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, to a reference value representing a known disease or health status, thereby diagnosing or prognosing depression in said subject, or determining whether said subject is at increased risk of developing said depression.

摘要翻译： 本发明涉及用于诊断或预测受试者中抑郁症，特别是抑郁症的方法，或确定受试者是否处于发展中的抑郁症，特别是重度抑郁症的风险增加的方法，其包括：确定水平或活动，或 在所述受试者的样品中表达神经营养因子3和/或编码神经营养因子3的基因的转录产物的水平和所述活性; 以及将所述水平或所述活动或所述水平和所述活动两者比较为代表已知疾病或健康状况的参考值，从而诊断或预测所述受试者的抑郁症，或者确定所述受试者是否处于发展所述受试者的风险增加 萧条。