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公开(公告)号：US20160333114A1
公开(公告)日：2016-11-17
申请号：US15156159
申请日：2016-05-16
申请人： City of Hope
发明人： John C. Williams , Christine Brown
IPC分类号： C07K16/40 , C07K14/705 , C07K14/725
CPC分类号： C07K16/40 , C07K14/7051 , C07K14/70521 , C07K16/32 , C07K2317/24 , C07K2317/622 , C07K2318/20 , C07K2319/03 , C07K2319/70
摘要： Provided herein are compositions which exhibit novel diagnostic capabilities and allow to rapidly add functionality to adoptive immunotherapy. The compositions include isolated nucleic acids encoding proteins including antibody regions capable of binding compounds including a peptidyl moiety (e.g., a meditope). The recombinant proteins provided herein are useful, inter alia, for a broad variety of therapeutic and diagnostic purposes. For example, the recombinant proteins provided herein including embodiments thereof may be used as non-invasive means to characterize chimeric antigen receptor (CAR) T cells before and/or during treatment of diseases (e.g., cancer).
摘要翻译： 本文提供了表现出新的诊断能力并允许快速添加过继性免疫治疗功能的组合物。 组合物包括编码蛋白质的分离的核酸，包括能够结合化合物的抗体区域，所述化合物包括肽基部分（例如，中间体）。 本文提供的重组蛋白尤其可用于多种治疗和诊断目的。 例如，本文提供的重组蛋白质包括其实施方案可以用作在疾病（例如癌症）治疗之前和/或期间表征嵌合抗原受体（CAR）T细胞的非侵入性手段。
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公开(公告)号：US09428553B2
公开(公告)日：2016-08-30
申请号：US13764762
申请日：2013-02-11
申请人： City of Hope
CPC分类号： C07K14/001 , A61K47/48346 , A61K47/48746 , A61K47/66 , A61K47/6897 , B82Y5/00 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US20140113348A1
公开(公告)日：2014-04-24
申请号：US13764762
申请日：2013-02-11
申请人： CITY OF HOPE
IPC分类号： C07K14/00
CPC分类号： C07K14/001 , A61K47/48346 , A61K47/48746 , A61K47/66 , A61K47/6897 , B82Y5/00 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
摘要翻译： 提供了与抗体结合的抗体和沉默剂，以及包含中间体和抗体的复合物，组合物和组合，以及生产，使用，测试和筛选其中的方法，包括治疗和诊断方法和用途。
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公开(公告)号：US20230250157A1
公开(公告)日：2023-08-10
申请号：US18060814
申请日：2022-12-01
IPC分类号： C07K16/10
CPC分类号： C07K16/10 , C07K2317/92 , C07K2317/76
摘要： Disclosed herein include antibodies or fragments thereof having specificity to a sarbecovirus spike protein receptor binding domain. Also provided are compositions, methods, and kits for isolating and using said antibodies or fragments thereof for preventing or treating, for example a coronavirus infection.
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公开(公告)号：US20230085485A1
公开(公告)日：2023-03-16
申请号：US17660603
申请日：2022-04-25
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US20230001003A1
公开(公告)日：2023-01-05
申请号：US17556863
申请日：2021-12-20
申请人： City of Hope
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US11311622B2
公开(公告)日：2022-04-26
申请号：US16460957
申请日：2019-07-02
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US11116834B2
公开(公告)日：2021-09-14
申请号：US16342426
申请日：2017-10-19
申请人： CITY OF HOPE
IPC分类号： C07K16/28 , C07K14/705 , C07K14/725 , A61K39/00 , A61K35/17 , A61K39/245 , A61P35/00 , C07K14/03 , C07K16/18 , A61K38/00
摘要： Provided herein are, inter alia, methods and compositions including T cells expressing (i) a recombinant CAR protein which includes a peptide binding site and is capable of specifically binding cancer-specific antigens and (ii) a T cell receptor specific for a viral antigen (e.g., a CMV pp65 protein). The engineered T cells provided herein may be used in combination with a viral vaccine (e.g. cytomegalovirus (CMV) Triplex Vaccine) to treat a variety of cancers. The methods described herein also permit in viva expansion of CMV-specific CAR T cells, instead of or in addition to ex vivo expansion, avoiding excessive T cell exhaustion that results in some cases from ex vivo manufacturing.
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公开(公告)号：US10357571B2
公开(公告)日：2019-07-23
申请号：US14949648
申请日：2015-11-23
发明人： John C. Williams , Cindy Zer , Kendra N. Avery , Ulrich Rodeck , Joshua M. Donaldson , Csaba Kari
摘要： In one embodiment, a masked monoclonal antibody (mAb) is provided, the mAb, encoded by a nucleic acid sequence or an amino acid sequence molecule comprising a signal sequence, a masking epitope sequence, a linker sequence that is cleavable by a protease specific to a target tissue; and an antibody or a functional fragment thereof. In another embodiment, a masked monoclonal antibody (mAb) is provided, which includes a therapeutic mAb and a mask, the mask comprising protein A and protein L attached by a protease cleavable linker.
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公开(公告)号：US09669108B2
公开(公告)日：2017-06-06
申请号：US14453586
申请日：2014-08-06
申请人： City of Hope
发明人： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua M. Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra N. Avery , Jun Xie
IPC分类号： C07K16/18 , C07K7/00 , A61K47/48 , A61K38/00 , A61K39/00 , A61K51/10 , C07K16/28 , C07K16/32 , B82Y5/00
CPC分类号： A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
摘要： Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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