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    Thiopyrano(2,3,4-c,d) indolyloxime ether alkylcarboxylates
    13.
    发明授权
    Thiopyrano(2,3,4-c,d) indolyloxime ether alkylcarboxylates 失效
    噻哆醇（2,3,4-c，d）吲哚肟醚烷基羧酸盐

    公开(公告)号：US5420282A

    公开(公告)日：1995-05-30

    申请号：US197422

    申请日：1994-02-15

    申请人： Dee W. Brooks ,  Pramila Bhatia

    发明人： Dee W. Brooks ,  Pramila Bhatia

    IPC分类号： C07D495/06 ,  C07D495/08 ,  A61K31/44 ,  A61K31/47

    CPC分类号： C07D495/06

    摘要： Compounds of the structure ##STR1## wherein R.sup.1 is selected from the group consisting of ##STR2## are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

    摘要翻译： 结构的化合物，其中R1选自是脂氧合酶的有效抑制剂，从而抑制白细胞三烯的生物合成。 这些化合物可用于治疗或改善过敏性和炎性疾病状态。

    Indole iminooxy derivatives which inhibit leukotriene biosynthesis
    15.
    发明授权
    Indole iminooxy derivatives which inhibit leukotriene biosynthesis 失效
    抑制白细胞三烯生物合成的吲哚亚氨氧基衍生物

    公开(公告)号：US5399699A

    公开(公告)日：1995-03-21

    申请号：US186410

    申请日：1994-01-24

    申请人： Teodozyi Kolasa ,  Pramila Bhatia ,  Dee W. Brooks

    发明人： Teodozyi Kolasa ,  Pramila Bhatia ,  Dee W. Brooks

    IPC分类号： C07D401/12 ,  C07D417/12 ,  C07D401/02 ,  A61K31/425 ,  A61K31/47 ,  C07D417/02

    CPC分类号： C07D401/12 ,  C07D417/12

    摘要： Compounds of the structure ##STR1## where A.sub.1 is alkylene or cycloalkylene; A.sub.2 is a valence bond, alkylene, or cycloalkylene; R.sub.1 is selected from hydrogen, alkylthio, optionally substituted phenylthio, optionally substituted phenylalkylthio, optionally substituted 2-, 3- and 4-pyridylthio, optionally substituted 2- and 3-thienylthio, and optionally substituted 2-thiazolylthio; R.sup.2 is selected from optionally substituted phenylalkyl and optionally substituted heteroarylakyl; R.sup.3 is selected from alkyl, alkoxy, optionally substituted phenyl, optionally substituted phenoxy, optionally substituted phenylalkyl, optionally substituted phenylalkoxy, optionally substituted naphthyl,optionally substituted naphthyloxy, optionally substituted naphthylalkyl, optionally substituted naphthylalkoxy, optionally substituted heteroaryl, optionally substituted heteroaryloxy, optionally substituted heteroarylalkyl, and optionally substituted heteroarylalkoxy; R.sup.4 is selected from hydrogen and optionally substituted alkyl; and Z is selected from --COOB, --C(OB)R.sup.6 R.sup.6, --COOalkyl, --COOalkylaryl, --CONR.sup.5 R.sup.6, and --COR.sup.6 are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment of amelioration of allergic and inflammatory disease states.

    摘要翻译： 其中A1是亚烷基或亚环烷基的结构的化合物; A2是价键，亚烷基或亚环烷基; R 1选自氢，烷硫基，任选取代的苯硫基，任选取代的苯基烷硫基，任选取代的2-，3-和4-吡啶硫基，任选取代的2-和3-噻吩硫基，以及任选取代的2-噻唑基硫基; R2选自任选取代的苯基烷基和任选取代的杂芳基; R 3选自烷基，烷氧基，任选取代的苯基，任选取代的苯氧基，任选取代的苯基烷基，任选取代的苯基烷氧基，任选取代的萘基，任选取代的萘基氧基，任选取代的萘基烷基，任选取代的萘基烷氧基，任选取代的杂芳基，任选取代的杂芳氧基， 杂芳基烷基和任选取代的杂芳基烷氧基; R4选自氢和任选取代的烷基; 并且Z选自-COOB，-C（OB）R 6 R 6，-COO烷基，-COO烷基芳基，-CONR 5 R 6和-COR 6是脂氧合酶的有效抑制剂，因此抑制白细胞三烯的生物合成。 这些化合物可用于治疗改善变态反应和炎性疾病状态。