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公开(公告)号：US09158018B2
公开(公告)日：2015-10-13
申请号：US13333620
申请日：2011-12-21
Applicant: Rodrigo Fuck , Christopher H. Chapman , James Rickett , Colin Thomson
Inventor： Rodrigo Fuck , Christopher H. Chapman , James Rickett , Colin Thomson
Abstract: Forward modeling is performed to compute a response of a target structure, the forward modeling accounting for distortion of a reflected signal from a reflector in the target structure. Waveform inversion is performed using the response of the forward modeling.
Abstract translation: 执行正向建模以计算目标结构的响应，正向建模考虑来自目标结构中的反射器的反射信号的失真。 使用正向建模的响应来执行波形反转。
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公开(公告)号：US20060166980A1
公开(公告)日：2006-07-27
申请号：US11385861
申请日：2006-03-22
Applicant: Annika Bjore , Magnus Bjorsne , David Cladingboel , Kurt-Jurgen Hoffmann , John Pavey , Fritiof Ponten , Gert Strandlund , Peder Svensson , Colin Thomson , Michael Wilsterman
Inventor： Annika Bjore , Magnus Bjorsne , David Cladingboel , Kurt-Jurgen Hoffmann , John Pavey , Fritiof Ponten , Gert Strandlund , Peder Svensson , Colin Thomson , Michael Wilsterman
IPC: C07D487/04 , A61K31/538
CPC classification number: C07D498/08
Abstract: There is provided compounds of formula I, wherein R1, R2, R3, R4, R41 to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.
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公开(公告)号：US3966710A
公开(公告)日：1976-06-29
申请号：US523024
申请日：1974-11-12
Applicant: James W. McFarland , Colin Thomson
Inventor： James W. McFarland , Colin Thomson
IPC: C07D333/24 , C07D499/00 , C07D499/46 , C07D499/68
CPC classification number: C07D333/24 , C07D499/00 , Y10S514/96 , Y10S514/962
Abstract: 6-(Aminomethyl substituted phenyl- and thienylacetamido)-penicillanic acid and esters, and synthetic methods for the preparation thereof.
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公开(公告)号：US08395965B2
公开(公告)日：2013-03-12
申请号：US12447683
申请日：2007-08-21
Applicant: Colin Thomson
Inventor： Colin Thomson
CPC classification number: G01V1/303
Abstract: There is provided a method of direct waveform inversion of turning waves (311, 312, 313) to determine parameters characterizing properties of the earth or sub-sections of the earth, particularly of parts of the earth which are capable of trapping hydrocarbons with the inversion yielding from the wavefield of turning waves information representing or being equivalent to velocities or slownesses and/or the gradient of velocities or slownesses, particularly by evaluating wavefield data in the vicinity of turning points (33). The method can be applied sequentially as a survey sinking method.
Abstract translation: 提供了一种转向波（311,312,313）的直接波形反转的方法，以确定表征地球的地球或子部分，特别是地球部分能够捕获碳氢化合物的反应的特性的参数 从表示或相当于速度或慢度的转向波的波场产生和/或速度或慢度的梯度，特别是通过评估转折点附近的波场数据（33）。 该方法可以作为调查沉没法顺序应用。
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公开(公告)号：US08227622B2
公开(公告)日：2012-07-24
申请号：US12830577
申请日：2010-07-06
Applicant: Debra Ainge , Eric Merifield , Colin Thomson , Michael Butters , Ravi Ramakrishnan , Ravi Naidu Rayapati , Parhalad Ray Sharma
Inventor： Debra Ainge , Eric Merifield , Colin Thomson , Michael Butters , Ravi Ramakrishnan , Ravi Naidu Rayapati , Parhalad Ray Sharma
IPC: C07D209/30 , C07D209/12
CPC classification number: C07D209/40 , C07D209/30 , C07D209/32
Abstract: The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound (I): X is ═O, ═N—OH or ═N—OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or —CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.
Abstract translation: 本发明涉及式（X）化合物及其盐，以及它们在制备药物化合物（I）的合成制造方法中作为中间体的用途：X是= O，= N-OH或= N-OC（O ）我; Y是氢，Ph-或对氯苯硫基; Z是氢或-CH 2 COOR 1，其中R 1选自氢，任选取代的烃基和任选取代的杂环基。
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Patent Agency Ranking
公开(公告)号：US20110046394A1
公开(公告)日：2011-02-24
申请号：US12830577
申请日：2010-07-06
Applicant: Debra Ainge , Eric Merifield , Colin Thomson , Michael Butters , Ravi Ramakrishnan , Ravi Naidu Rayapati , Parhalad Ray Sharma
Inventor： Debra Ainge , Eric Merifield , Colin Thomson , Michael Butters , Ravi Ramakrishnan , Ravi Naidu Rayapati , Parhalad Ray Sharma
IPC: C07D209/30 , C07D209/24
CPC classification number: C07D209/40 , C07D209/30 , C07D209/32
Abstract: The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound (I): X is ═O, ═N—OH or ═N—OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or —CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.
Abstract translation: 本发明涉及式（X）化合物及其盐，以及它们在制备药物化合物（I）的合成制造方法中作为中间体的用途：X是= O，= N-OH或= N-OC（O ）我; Y是氢，Ph-或对氯苯硫基; Z是氢或-CH 2 COOR 1，其中R 1选自氢，任选取代的烃基和任选取代的杂环基。
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公开(公告)号：US20090043097A1
公开(公告)日：2009-02-12
申请号：US12121228
申请日：2008-05-15
Applicant: Colin Thomson , Andrew Watts , Michael Butters , Matthew James Welham , Richard Wisedale
Inventor： Colin Thomson , Andrew Watts , Michael Butters , Matthew James Welham , Richard Wisedale
IPC: C07D513/04
CPC classification number: C07D497/04 , C07D513/04
Abstract: A method for the preparation of a compound of formula (1) or a pharmaceutically acceptable salt or solvate thereof; from a compound of the formula: (IV); wherein L represents a leaving group.
Abstract translation: 一种制备式（1）化合物或其药学上可接受的盐或溶剂合物的方法; 由式（IV）表示的化合物： 其中L表示离去基团。
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18.发明授权Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid 失效制备2-（2,4-二氯苯氧基） - 苯乙酸的方法
公开(公告)号：US4404396A
公开(公告)日：1983-09-13
申请号：US338492
申请日：1982-01-11
Applicant: Colin Thomson , Neil J. Tweddle
Inventor： Colin Thomson , Neil J. Tweddle
IPC: A61K31/19 , A61P29/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07C51/00 , C07C51/367 , C07C59/68 , C07C67/00 , C07C65/00
CPC classification number: C07C51/367
Abstract: Process for the preparation of 2-(2,4-dichlorophenoxy)phenylacetic acid in which the potassium salts of 2-chlorophenylacetic acid and 2,4-dichlorophenol are reacted in aromatic hydrocarbon solvents at elevated temperatures in the presence of a copper chloride catalyst, followed thereafter by acidification.
Abstract translation: 制备2-（2,4-二氯苯氧基）苯乙酸的方法，其中2-氯苯基乙酸和2,4-二氯苯酚的钾盐在芳族烃溶剂中，在氯化铜催化剂存在下，在升高的温度下反应， 然后通过酸化。
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公开(公告)号：US4009160A
公开(公告)日：1977-02-22
申请号：US658489
申请日：1976-02-17
Applicant: James W. McFarland , Colin Thomson
Inventor： James W. McFarland , Colin Thomson
IPC: C07D499/00 , C07D499/46 , C07D499/58
CPC classification number: C07D499/00
Abstract: 6-(Aminomethyl substituted phenyl- and thienylacetamido)penicillanic acid and esters, and synthetic methods for the preparation thereof.
Abstract translation: 6-（氨基甲基取代的苯基和噻吩基乙酰胺基）青霉烷酸和酯，以及其制备的合成方法。
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公开(公告)号：US3997527A
公开(公告)日：1976-12-14
申请号：US658384
申请日：1976-02-17
Applicant: James W. McFarland , Colin Thomson
Inventor： James W. McFarland , Colin Thomson
IPC: C07D499/00 , C07D499/46 , C07D499/58
CPC classification number: C07D499/00
Abstract: 6-(Aminomethyl substituted phenyl- and thienylacetamido)-penicillanic acid and esters, and synthetic methods for the preparation thereof.
Abstract translation: 6-（氨基甲基取代的苯基 - 和噻吩基乙酰胺基） - 青霉烷酸和酯，以及其制备方法。
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