公开(公告)号：US20080167332A1

公开(公告)日：2008-07-10

申请号：US11779700

申请日：2007-07-18

Applicant: Scott Gibson ,  Barry Elkins ,  Mike Rogers ,  Ian Hassall ,  Hong Gu ,  Zhenyu Wang ,  Vinod Kumar ,  Synthana Suresh Kumar ,  Santosh Kavitake ,  Sidda Lingesha ,  Eric Merifield ,  David Ennis ,  John Pavey ,  Austen Pimm ,  James Reuberson ,  Bo-Goran Josefsson ,  Martin Hemmerling ,  Svetlana Ivanova ,  Marguerite Mensonides-Harsema ,  Hakan Schulz ,  John Mo ,  Tomas Eriksson ,  Per Strandberg

Inventor： Scott Gibson ,  Barry Elkins ,  Mike Rogers ,  Ian Hassall ,  Hong Gu ,  Zhenyu Wang ,  Vinod Kumar ,  Synthana Suresh Kumar ,  Santosh Kavitake ,  Sidda Lingesha ,  Eric Merifield ,  David Ennis ,  John Pavey ,  Austen Pimm ,  James Reuberson ,  Bo-Goran Josefsson ,  Martin Hemmerling ,  Svetlana Ivanova ,  Marguerite Mensonides-Harsema ,  Hakan Schulz ,  John Mo ,  Tomas Eriksson ,  Per Strandberg

IPC: A61K31/438 ,  A61P11/00 ,  C07D491/107 ,  C07C275/32 ,  C07D211/52 ,  C07C69/76 ,  C07C69/52 ,  C07C233/81 ,  C07C233/00 ,  C07D303/46 ,  A61P29/00

CPC classification number: C07C233/25 ,  C07C69/92 ,  C07C235/60 ,  C07D211/48 ,  C07D303/23 ,  C07D491/107

Abstract: Compounds of formula (I) wherein R1, R3, R4, R5, R6, R7, and R10 are as defined in the specification, are described. The present invention also relates to pharmaceutical composition comprising said compounds and to the use of said compounds in therapy. The present invention further relates to processes for the preparation of said compounds and to new intermediates useful in the preparation thereof. Beside, the invention relates to salts and polymorphic forms of the new compounds as well as the preparation thereof.

Abstract translation: 式（I）的化合物，其中R 1，R 3，R 4，R 5，R SUP > 6 ，R＆lt; 7＆gt;和＆lt; 10＆gt;如说明书中所定义。 本发明还涉及包含所述化合物的药物组合物和所述化合物在治疗中的用途。 本发明还涉及制备所述化合物的方法和可用于其制备的新中间体。 除此之外，本发明涉及新化合物的盐和多晶型物及其制备。

公开(公告)号：US20140364601A1

公开(公告)日：2014-12-11

申请号：US14117259

申请日：2012-05-11

Applicant: Neil Barnwell ,  Philip Cornwall ,  Duncan Michael Gill ,  Gareth P. Howell ,  Rebecca Elizabeth Meadows ,  Andiappan Murugan ,  Philip O'Keefe ,  John Singleton ,  Jane Withnall ,  Eric Merifield ,  Christopher William Mitchell ,  Zakariya Mohamed Patel ,  James Barry Rose

Inventor： Neil Barnwell ,  Philip Cornwall ,  Duncan Michael Gill ,  Gareth P. Howell ,  Rebecca Elizabeth Meadows ,  Andiappan Murugan ,  Philip O'Keefe ,  John Singleton ,  Jane Withnall ,  Eric Merifield ,  Christopher William Mitchell ,  Zakariya Mohamed Patel ,  James Barry Rose

IPC: C07D498/10 ,  C07C309/08 ,  C07D277/68 ,  C07C55/07

CPC classification number: C07D498/10 ,  C07C55/07 ,  C07C309/08 ,  C07C309/24 ,  C07D277/68

Abstract: Processes for the preparation of the compound of formula (II) and intermediate compounds for use in the processes.

Abstract translation: 用于制备式（II）化合物和用于该方法的中间体化合物的方法。

公开(公告)号：US20080051586A1

公开(公告)日：2008-02-28

申请号：US11813816

申请日：2006-01-09

Applicant: Philip Keegan ,  Eric Merifield ,  Duncan Gill

Inventor： Philip Keegan ,  Eric Merifield ,  Duncan Gill

IPC: C07D209/10 ,  C07D209/04

CPC classification number: C07D209/30 ,  C07D209/08

Abstract: The invention relates to a novel process for the preparation of substituted indoles which are useful as therapeutic agents.

Abstract translation: 本发明涉及一种制备可用作治疗剂的取代吲哚的新方法。

公开(公告)号：US08227622B2

公开(公告)日：2012-07-24

申请号：US12830577

申请日：2010-07-06

Applicant: Debra Ainge ,  Eric Merifield ,  Colin Thomson ,  Michael Butters ,  Ravi Ramakrishnan ,  Ravi Naidu Rayapati ,  Parhalad Ray Sharma

Inventor： Debra Ainge ,  Eric Merifield ,  Colin Thomson ,  Michael Butters ,  Ravi Ramakrishnan ,  Ravi Naidu Rayapati ,  Parhalad Ray Sharma

IPC: C07D209/30 ,  C07D209/12

CPC classification number: C07D209/40 ,  C07D209/30 ,  C07D209/32

Abstract: The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound (I): X is ═O, ═N—OH or ═N—OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or —CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.

Abstract translation: 本发明涉及式（X）化合物及其盐，以及它们在制备药物化合物（I）的合成制造方法中作为中间体的用途：X是= O，= N-OH或= N-OC（O ）我; Y是氢，Ph-或对氯苯硫基; Z是氢或-CH 2 COOR 1，其中R 1选自氢，任选取代的烃基和任选取代的杂环基。

公开(公告)号：US20110046394A1

公开(公告)日：2011-02-24

申请号：US12830577

申请日：2010-07-06

Applicant: Debra Ainge ,  Eric Merifield ,  Colin Thomson ,  Michael Butters ,  Ravi Ramakrishnan ,  Ravi Naidu Rayapati ,  Parhalad Ray Sharma

Inventor： Debra Ainge ,  Eric Merifield ,  Colin Thomson ,  Michael Butters ,  Ravi Ramakrishnan ,  Ravi Naidu Rayapati ,  Parhalad Ray Sharma

IPC: C07D209/30 ,  C07D209/24

CPC classification number: C07D209/40 ,  C07D209/30 ,  C07D209/32

Abstract: The invention relates to compounds of formula (X), and salts thereof, and their use as intermediates in improved manufacturing processes for the synthesis of pharmaceutical compound (I): X is ═O, ═N—OH or ═N—OC(O)Me; Y is hydrogen, PhS- or p-chlorophenylsulfanyl; Z is hydrogen or —CH2COOR1 wherein R1 is selected from hydrogen, optionally substituted hydrocarbyl and optionally substituted heterocyclyl.

Abstract translation: 本发明涉及式（X）化合物及其盐，以及它们在制备药物化合物（I）的合成制造方法中作为中间体的用途：X是= O，= N-OH或= N-OC（O ）我; Y是氢，Ph-或对氯苯硫基; Z是氢或-CH 2 COOR 1，其中R 1选自氢，任选取代的烃基和任选取代的杂环基。

公开(公告)号：US07781598B2

公开(公告)日：2010-08-24

申请号：US11813816

申请日：2006-01-09

Applicant: Philip Keegan ,  Eric Merifield ,  Duncan Gill

Inventor： Philip Keegan ,  Eric Merifield ,  Duncan Gill

IPC: C07D209/30 ,  C07D209/04 ,  C07D209/08

CPC classification number: C07D209/30 ,  C07D209/08

Abstract: The invention relates to a novel process for the preparation of substituted indoles which are useful as therapeutic agents.

Abstract translation: 本发明涉及一种制备可用作治疗剂的取代吲哚的新方法。