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公开(公告)号：US20210240886A1
公开(公告)日：2021-08-05
申请号：US17163435
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
Abstract: A method, according to some implementations, includes displaying an interface structured to evaluate design data by a group of users and identifying user parameters for each user in the group. The method ma further include configuring the interface for each user in the group based at least in part on the user parameters, receiving, via the interface, user input data from one or more users in the group, and scoring designs based on the user input and user parameters.
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公开(公告)号：US20250022551A1
公开(公告)日：2025-01-16
申请号：US18899259
申请日：2024-09-27
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC: G16H10/20 , G06F30/10 , G06F30/12 , G06F30/20 , G06F111/02 , G06F111/04 , G06F111/06 , G06F111/08 , G06F111/16 , G06N5/04 , G06N20/00 , G06Q10/0631 , G06Q10/067 , G06Q30/0204 , G16H40/20 , G16H50/70
Abstract: A method for searching clinical trial designs that includes: determining a first convex hull set from a first set of clinical trial designs for a first scenario; simulating the first convex hull set for a second scenario to determine first simulation results; removing the first convex hull set from the first set of clinical trial designs to generate a second set of clinical trial designs; determining a second convex hull set from the second set of clinical trial designs for the first scenario; simulating the second convex hull set for the second scenario to determine second simulation results; determining, based at least in part on the first simulation results and the second simulation results, a refined scenario convex hull set of clinical trial designs for the second scenario from the first convex hull set and the second convex hull set; and transmitting the refined scenario convex hull set.
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公开(公告)号：US20220374558A1
公开(公告)日：2022-11-24
申请号：US17847040
申请日：2022-06-22
Applicant: Cytel Inc.
Inventor： Nitin Patel , Jaydeep Bhattacharyya , Albert M. Kim , Yannis Jemiai , Jay Kyle Wathen , Sagar Mehta , Christopher Michael Porayko
Abstract: A method for trial design analysis that includes receiving, for each trial design of a plurality of trial designs, a set of simulated performance criteria for a set of trial designs, and visualizing, on a graph, values for a first simulated performance criteria and a second simulated performance criteria from the set of simulated performance criteria for each trial design using a location of points on the graph corresponding to the set of trial designs. The method further includes identifying optimal designs based on an optimality criteria using the set of the simulated performance criteria, and determining a tradeoff metric for the first simulated performance criteria and the second simulated performance criteria. The method further includes displaying, the tradeoff metric as a set of lines on the graph, wherein a slope of the lines corresponds to a value of the tradeoff metric.
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公开(公告)号：US20210241864A1
公开(公告)日：2021-08-05
申请号：US17163436
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
Abstract: A method for trial design with simulated annealing includes obtaining, via at least one processor of a trial design platform, initial trial design simulation results data for a set of trial designs. The method may further include identifying an initial design from the design simulation results data, predicting, performance data of designs for variations of parameters corresponding to the set of trial designs, and identifying a new design for simulation by varying parameters of the initial simulated design based on the predicting. The method may also include simulating the new design, determining performance data of the new design, and identifying a second new design for simulation by varying parameters of the new design based on the simulated performance of the new design.
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公开(公告)号：US20210241863A1
公开(公告)日：2021-08-05
申请号：US17163433
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
Abstract: A method, according to some implementations, determining, via at least one processor, a plurality of possible sites for recruiting patients from for a trial and determining, via the at least one processor and for each of one or more subgroupings of the plurality of possible sites, a predicted available resources value. The method may further include determining, via the at least one processor, which subgrouping of the plurality of possible sites has a predicted available resources value that globally optimizes a desired site resource criteria.
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Patent Agency Ranking
公开(公告)号：US12211593B2
公开(公告)日：2025-01-28
申请号：US17163427
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC: G16H10/20 , G06F30/10 , G06F30/12 , G06F30/20 , G06F111/02 , G06F111/04 , G06F111/06 , G06F111/08 , G06F111/16 , G06N5/04 , G06N20/00 , G06Q10/0631 , G06Q10/067 , G06Q30/0204 , G16H40/20 , G16H50/70
Abstract: A method, according to some implementations, includes obtaining trial design simulation results for a set of trial designs and determining a set of Pareto designs in the set of trial designs based at least in part on the trial design simulation results and one or more performance parameters. The method further includes determining a set of convex hull designs in the set of trial designs, determining a set of recommended designs based at least in part on the set of Pareto designs and the set of convex hull designs, and transmitting the set of recommended designs.
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公开(公告)号：US12040059B2
公开(公告)日：2024-07-16
申请号：US17163425
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharyya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
IPC: G16H10/20 , G06F30/10 , G06F30/12 , G06F30/20 , G06N5/04 , G06N20/00 , G06Q10/0631 , G06Q10/067 , G06Q30/0204 , G16H40/20 , G16H50/70 , G06F111/02 , G06F111/04 , G06F111/06 , G06F111/08 , G06F111/16
CPC classification number: G16H10/20 , G06F30/10 , G06F30/12 , G06F30/20 , G06N5/04 , G06N20/00 , G06Q10/06315 , G06Q10/067 , G06Q30/0205 , G16H40/20 , G16H50/70 , G06F2111/02 , G06F2111/04 , G06F2111/06 , G06F2111/08 , G06F2111/16
Abstract: A method for determining trial designs is provided. The method includes receiving, via at least one processor, one or more trial design criteria and one or more scenarios corresponding to a set of trial designs, and generating, via the at least one processor, simulation data based at least in part on replicating each of the set of trial designs with the one or more trial design criteria and the one or more scenarios. The simulation data includes performance parameters and performance parameter values associated with each design in the set of designs for a set of criteria. The method further includes determining, via the at least one processor, an optimality criteria for evaluating the trial designs, searching, within the set of trial designs, via the at least one processor, for globally optimum designs based on the optimality criteria, and transmitting, via the at least one processor, globally optimum designs.
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公开(公告)号：US20220382935A1
公开(公告)日：2022-12-01
申请号：US17847025
申请日：2022-06-22
Applicant: Cytel Inc.
Inventor： Nitin Patel , Jaydeep Bhattacharyya , Albert M. Kim , Yannis Jemiai , Jay Kyle Wathen , Sagar Mehta , Christopher Michael Porayko
IPC: G06F30/20
Abstract: A method, according to some implementations, receiving, for each trial design of a set of trial designs, a simulated performance and presenting, for at least two criteria, a plot of the simulated performance. The method may further include presenting, for at least one additional criteria, a plurality of contour lines on the plot and selecting a subset of the set of trial designs based on the plurality of contour lines.
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公开(公告)号：US20210241865A1
公开(公告)日：2021-08-05
申请号：US17163437
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
Abstract: A method, according to some implementations, includes providing inputs to a plurality of trial design simulation engines, receiving first outputs of the plurality of trial design simulation engines in response to the inputs, and providing variations of the inputs to the plurality of trial design simulation engines. The method may further include receiving second outputs of the plurality of trial design simulation engines in response to the variations evaluating the first and the second outputs to determine delta values, and determining, based in part on the delta values, a plurality of normalization factors for the plurality of trial design simulation engines.
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公开(公告)号：US20210241861A1
公开(公告)日：2021-08-05
申请号：US17163431
申请日：2021-01-30
Applicant: Cytel Inc.
Inventor： Jaydeep Bhattacharya , James Bolognese , Alexandre Buer , Eric Edwards , Stanley Y. Huang , Yannis Jemiai , Cyrus Mehta , Nitin Patel , Anne Pelz , Ajay Prabhakar Sathe , Joshua A. Schultz , Pralay Senchaudhuri
Abstract: A method, according to some implementations, includes determining, via at least one processor, a plurality of possible sites for recruiting patients from for a trial and determining, via the at least one processor and for each of one or more subgroupings of the plurality of possible sites, a predicted patient recruitment value. The method may include determining, via the at least one processor, a candidate subgrouping of the plurality of possible sites having a predicted patient recruitment value that globally optimizes a desired site selection criteria, and transmitting, via the at least one processor, data corresponding to the candidate subgrouping.
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