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公开(公告)号：US20240096611A1
公开(公告)日：2024-03-21
申请号：US18262852
申请日：2022-02-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas R. COVEY , Chang LIU , Hui ZHANG
IPC: H01J49/04
CPC classification number: H01J49/0431 , H01J49/0454
Abstract: A method of sampling an ejection of a sample from a liquid container includes disposing the liquid container adjacent an open port in-terface. The container includes a sampling port. The open port interface en-gages with the sampling port. The sample from the liquid container is eject-ed, through the sampling port, and into the open port interface. The sample is analyzed with a mass spectrometry device.
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公开(公告)号：US20230096792A1
公开(公告)日：2023-03-30
申请号：US17908659
申请日：2021-03-02
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Don W. ARNOLD , Thomas R. COVEY , Chang LIU
Abstract: An electromagnetic sampling device is disclosed, which comprises a needle having a hollow housing that extends from a proximal end to a distal end, and an electromagnet comprising an electromagnetic coil and a metal core, at least a portion of said metal core extending through said hollow housing of the needle and be configured to transition between an extended position in which the distal end of the metal core extends beyond the distal end of the needle's hollow housing and a retracted position in which the distal end of the metal core is positioned within the needle's housing, wherein an activation of said electromagnetic coil magnetizes the metal core.
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13.发明申请公开(公告)号：US20240418686A1
公开(公告)日：2024-12-19
申请号：US18688485
申请日：2022-09-02
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Chang LIU , Gordana IVOSEV , Alandra QUINN
Abstract: Methods and systems for assessing a quality of mass analysis data generated by a mass analysis device, including collecting mass spectrometry data for a given compound, deriving a measured isotope profile based on the collected mass spectrometry data, determining a predicted isotope profile, determining a first quality score for the mass analysis data, the first quality score being based on a relationship between an intensity of the main peak and intensities of the one or more isotope peaks, determining a second quality score for the mass analysis data, the second quality score being based on a signal-to-noise ratio of the mass analysis data, determining an overall quality score as a combination of the first quality score and the second quality score, and assessing a quality of a compound library based on the determined overall quality score.
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公开(公告)号：US20240290595A1
公开(公告)日：2024-08-29
申请号：US18568404
申请日：2022-06-08
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas COVEY , Chang LIU
CPC classification number: H01J49/0009 , H01J49/0404
Abstract: In one aspect, a calibration system for use in a mass spectrometer having an open port interface (OPI) for receiving a sample for mass analysis is disclosed, which includes a fluidic junction having a first inlet in fluid communication with a first reservoir, which is configured for storing a calibration liquid, and a second inlet in fluid communication with a second reservoir, which is configured for storing a transport liquid. The fluidic junction can further include an outlet in fluid communication with the first and second inlets such that any of the calibration liquid and the transport liquid can exit the fluidic junction via said outlet.
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15.发明公开公开(公告)号：US20240282563A1
公开(公告)日：2024-08-22
申请号：US18569787
申请日：2022-06-24
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Thomas COVEY , Chang LIU
CPC classification number: H01J49/0404 , H01J49/0031 , H01J49/0413 , H01J49/0431
Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings. MS-based systems and methods are provided in which the flow of solvent into an open port sampling probe fluidly coupled to an ion source can be selectively stopped during the addition of one or more reagents into the drained open end of the sampling probe. Upon re-initiating the flow of solvent, the reagents and/or the reaction products can be delivered to the ion source. In one aspect, a method for chemical analysis is provided, the method comprising directing a flow of a first solvent from a solvent conduit to an ion source via a sampling space of a sampling probe, wherein the sampling space is at least partially defined by an open end of the sampling probe. The flow of the first solvent into the sampling space from the solvent conduit may be terminated for a first duration, and the sampling space drained. A second solvent and one or more reactants may then be added to the drained sampling space through the open end during the first duration. Thereafter, the flow of the first solvent may again be directed from the solvent conduit to the ion source via the sampling space such that the second solvent is delivered to the ion source, and such that one or more reaction products contained within the second solvent and generated by said one or more reactants may be ionized for mass spectrometric analysis.
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Patent Agency Ranking
公开(公告)号：US20240159716A1
公开(公告)日：2024-05-16
申请号：US18550001
申请日：2022-03-18
Applicant: DH Technologies Development Pte. Ltd.
Inventor： David Michael COX , Chang LIU
CPC classification number: G01N30/20 , B01D15/14 , G01N30/22 , G01N30/7233 , G01N2030/201
Abstract: A method of performing liquid chromatography (LC) with an LC system including an LC column and an analyzer includes delivering a transport liquid to an open port interface (OPI) of a sample receiving circuit, wherein the sample receiving circuit includes a sample transfer chamber. A sample is ejected from a sample holder into the OPI with a non-contact ejector. The transport liquid and the sample are received in the sample transfer chamber. The sample transfer chamber is decoupled from the sample receiving circuit. A solvent is delivered to the analysis circuit. The sample is pushed from the sample transfer chamber with the solvent. The sample and the solvent is passed through the LC column to produce an eluent. The eluent is analyzed with the analyzer.
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公开(公告)号：US20240038518A1
公开(公告)日：2024-02-01
申请号：US18258359
申请日：2021-12-22
Applicant: DH Technologies Development Pte. Ltd.
CPC classification number: H01J49/0454 , H01J49/0031
Abstract: A method of ejecting a plurality of samples from a well plate includes receiving a first sample intensity prediction associated with a first sample in a first well of the well plate. A second sample intensity prediction associated with a second sample in a second well is also received. The second sample intensity prediction is less than the first sample intensity prediction. An ejection time delay value for a subsequent analysis of the first sample and the second sample is determined, based at least in part on the second sample intensity prediction. Thereafter, the first sample is acoustically ejected from the first well, and the second sample is acoustically ejected from the second well.
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公开(公告)号：US20230236201A1
公开(公告)日：2023-07-27
申请号：US17999621
申请日：2021-05-20
Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
Inventor： Thomas R. COVEY , Chang LIU
IPC: G01N33/68 , G01N33/543 , G01N27/624 , G01N27/74
CPC classification number: G01N33/6851 , G01N33/54326 , G01N27/624 , G01N27/745
Abstract: In a system for affinity selection by mass spectrometry, wherein a plurality of drug candidates in solution are separated based on affinity, a method is provided comprising introducing a solid-phase device having binding affinity for a selected protein into the solution, binding at least one of the plurality of drug candidates to the solid-phase device as a selected drug candidate, washing the solid-phase device and selected drug candidate to separate unbound material, sampling the selected drug candidate in capture fluid flowing through a sampling region of an open port sampling interface and directing the sampled selected drug candidate and capture fluid to an ionization source.
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公开(公告)号：US20240404807A1
公开(公告)日：2024-12-05
申请号：US18694178
申请日：2022-09-23
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Gordana IVOSEV , Chang LIU
Abstract: A method for determining a convolved peak intensity in a sample trace includes ejecting a plurality of sample ejections from a sample well plate. An ejection time log is generated which includes an ejection time of each of the plurality of sample ejections from the sample well plate. The plurality of sample ejections is analyzed with a mass analyzer. The sample trace of intensity versus time values is produced for the plurality of sample ejections based on the analysis. A known peak shape is obtained. A convolved peak intensity is determined for a convolved peak of the sample trace based at least in part on the known peak shape and the ejection time log.
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公开(公告)号：US20240395522A1
公开(公告)日：2024-11-28
申请号：US18693311
申请日：2022-09-19
Applicant: DH Technologies Development Pte. Ltd.
Inventor： Gordana IVOSEV , Chang LIU , Stephen TATE , Hui ZHANG
IPC: H01J49/00
Abstract: A method for performing mass spectrometry (MS) comprises receiving MS data corresponding to a plurality of MS runs, wherein MS data corresponding to an MS run of the plurality of MS runs comprises detected intensities for a plurality of mass over charge ratios (MZ values) during the MS run; finding a recurrent MZ value of the plurality of MZ values, wherein a detected intensity for the recurrent MZ value appears as a recurrent peak in MS data corresponding to a subset of the plurality of MS runs; and the subset of the plurality of MS runs includes at least two MS runs of the plurality of MS runs; and identifying the recurrent MZ value as corresponding to a background ion.
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