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    SYSTEMS AND METHODS FOR CONTROLLING FLOW THROUGH AN OPEN PORT INTERFACE
    2.
    发明公开
    SYSTEMS AND METHODS FOR CONTROLLING FLOW THROUGH AN OPEN PORT INTERFACE 审中-公开

    公开(公告)号：US20240112901A1

    公开(公告)日：2024-04-04

    申请号：US18257611

    申请日：2021-12-21

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Chang LIU ,  Thomas COVEY ,  Peter KOVARIK

    IPC: H01J49/06 ,  H01J49/16

    CPC classification number: H01J49/068 ,  H01J49/165

    Abstract: A method of adjusting a position of an electrode within a nebulizer probe of a mass spectrometry device having an open port interface for receiving a sample includes performing a first analysis of the sample at a first analysis condition including a first position of the electrode and a first flow rate. After performing the first analysis, a second analysis of the sample is performed at a second analysis condition including the first position of the electrode and a second flow rate higher than the first flow rate. Thereafter, a third analysis of the sample is performed at a third analysis condition including a second position of the electrode and the second flow rate.

    Bioanalysis Workflow with Direct Ejection from Phase-Separated Samples
    3.
    发明公开
    Bioanalysis Workflow with Direct Ejection from Phase-Separated Samples 审中-公开

    公开(公告)号：US20240272173A1

    公开(公告)日：2024-08-15

    申请号：US18568398

    申请日：2022-06-08

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas COVEY ,  Yuzhu GUO ,  Chang LIU

    IPC: G01N33/68 ,  G01N30/06 ,  G01N30/72

    CPC classification number: G01N33/6851 ,  G01N30/06 ,  G01N30/7233

    Abstract: In one aspect, a method of introducing a sample into an open port interface (OPI) of a mass spectrometer is disclosed, which includes mixing the sample with a solvent in which a matrix of an aqueous phase of the sample is immiscible and in which at least a target analyte, when present in the sample, is miscible so as to extract at least a portion of the target analyte into said at least one solvent, thereby generating a multi-phase liquid having said aqueous phase and one or more organic phases, wherein at least one of those organic phases contains at least a portion of the target analyte. In some embodiments, the method further calls for ejecting a plurality of droplets from at least one of the phases of the multi-phase liquid for introduction into the OPI of the mass spectrometer.

    MS Calibration for OPI-MS
    5.
    发明公开
    MS Calibration for OPI-MS 审中-公开

    公开(公告)号：US20240290595A1

    公开(公告)日：2024-08-29

    申请号：US18568404

    申请日：2022-06-08

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas COVEY ,  Chang LIU

    IPC: H01J49/00 ,  H01J49/04

    CPC classification number: H01J49/0009 ,  H01J49/0404

    Abstract: In one aspect, a calibration system for use in a mass spectrometer having an open port interface (OPI) for receiving a sample for mass analysis is disclosed, which includes a fluidic junction having a first inlet in fluid communication with a first reservoir, which is configured for storing a calibration liquid, and a second inlet in fluid communication with a second reservoir, which is configured for storing a transport liquid. The fluidic junction can further include an outlet in fluid communication with the first and second inlets such that any of the calibration liquid and the transport liquid can exit the fluidic junction via said outlet.

    Methods and Systems for Performing Reactions Within Direct Sampling Interfaces for Mass Spectrometric Analysis
    6.
    发明公开
    Methods and Systems for Performing Reactions Within Direct Sampling Interfaces for Mass Spectrometric Analysis 审中-公开

    公开(公告)号：US20240282563A1

    公开(公告)日：2024-08-22

    申请号：US18569787

    申请日：2022-06-24

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： Thomas COVEY ,  Chang LIU

    IPC: H01J49/04 ,  H01J49/00

    CPC classification number: H01J49/0404 ,  H01J49/0031 ,  H01J49/0413 ,  H01J49/0431

    Abstract: Methods and systems for delivering a liquid sample to an ion source for the generation of ions and subsequent analysis by mass spectrometry are provided herein. In accordance with various aspects of the present teachings. MS-based systems and methods are provided in which the flow of solvent into an open port sampling probe fluidly coupled to an ion source can be selectively stopped during the addition of one or more reagents into the drained open end of the sampling probe. Upon re-initiating the flow of solvent, the reagents and/or the reaction products can be delivered to the ion source. In one aspect, a method for chemical analysis is provided, the method comprising directing a flow of a first solvent from a solvent conduit to an ion source via a sampling space of a sampling probe, wherein the sampling space is at least partially defined by an open end of the sampling probe. The flow of the first solvent into the sampling space from the solvent conduit may be terminated for a first duration, and the sampling space drained. A second solvent and one or more reactants may then be added to the drained sampling space through the open end during the first duration. Thereafter, the flow of the first solvent may again be directed from the solvent conduit to the ion source via the sampling space such that the second solvent is delivered to the ion source, and such that one or more reaction products contained within the second solvent and generated by said one or more reactants may be ionized for mass spectrometric analysis.

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