公开(公告)号：US20180208576A1

公开(公告)日：2018-07-26

申请号：US15745754

申请日：2016-07-07

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie BOUDON ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: C07D401/10 ,  C07D265/30 ,  C07D223/04 ,  C07D211/16 ,  A61K8/49 ,  A61Q19/08

CPC classification number: C07D401/10 ,  A61K8/49 ,  A61K8/4906 ,  A61K8/4926 ,  A61Q19/08 ,  C07D211/16 ,  C07D223/04 ,  C07D265/30

Abstract: The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.

公开(公告)号：US20250032439A1

公开(公告)日：2025-01-30

申请号：US18715405

申请日：2022-12-05

Applicant: DSM IP ASSETS B.V.

Inventor： Christine MENDROK-EDINGER ,  Eileen JACKSON ,  Angela WILDERMANN ,  Peter Louis HOUSTON

IPC: A61K31/222 ,  A61K8/67 ,  A61Q19/00

Abstract: The present invention relates to novel compositions comprising a retinoid mixture of cis and trans isomers of a retinyl ester, particularly retinyl acetate, with a cis/trans ratio of less than 0.03 as well as the use thereof for the treatment, prevention and lessening of the symptoms of diseases and conditions which can be treated with 5-HT2B serotonin receptor antagonists, including but not limited to diseases or conditions selected from migraine headaches, anxiety, ocular hypotension, heart valve disease, irritable bowel syndrome, and MDMA (commonly called “ecstasy”) abuse.

公开(公告)号：US20210277058A1

公开(公告)日：2021-09-09

申请号：US16338758

申请日：2017-10-02

Applicant: DSM IP ASSETS B.V.

Inventor： Marc HEIDL ,  Eileen JACKSON

IPC: C07K7/06 ,  A61Q19/04 ,  A61K8/64 ,  A61K8/25 ,  A61K8/29 ,  A61K8/23 ,  A61K8/27 ,  A61K8/34

Abstract: The present invention relates to novel selective melanocortin-1 receptor (MC1R) agonists as well as the use thereof as skin tanning agents.

公开(公告)号：US20200290960A1

公开(公告)日：2020-09-17

申请号：US16061418

申请日：2016-12-14

Applicant: DSM IP ASSETS B.V.

Inventor： Igor BENDIK ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: C07C401/00 ,  A61K8/34 ,  A61Q19/08

Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

公开(公告)号：US20190290563A1

公开(公告)日：2019-09-26

申请号：US16062279

申请日：2016-12-14

Applicant: DSM IP ASSETS B.V.

Inventor： Igor BENDIK ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: A61K8/34 ,  A61K8/06 ,  A61Q19/08 ,  C07C33/28

Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.

公开(公告)号：US20190002378A1

公开(公告)日：2019-01-03

申请号：US16061697

申请日：2016-12-14

Applicant: DSM IP ASSETS B.V.

Inventor： Igor BENDIK ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: C07C33/28 ,  A61Q19/08 ,  A61K8/67 ,  C07C33/48

CPC classification number: C07C33/28 ,  A61K8/345 ,  A61K8/67 ,  A61Q19/00 ,  A61Q19/08 ,  C07C33/486

Abstract: Novel biaromatic compounds, which are vitamin D analogs, processes for their preparation and cosmetic, dermatological and pharmaceutical preparations containing one or more of these compounds.