公开(公告)号：US20180319829A1

公开(公告)日：2018-11-08

申请号：US15774649

申请日：2016-11-23

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie BOUDON ,  Eileen JACKSON ,  Rolf SCHUETZ ,  Jürgen Herbert VOLLHARDT ,  Peter WIKSTROEM ,  Eliane Ursula WANDELER

IPC: C07F9/6553 ,  A61K8/55 ,  A61K31/67 ,  A61Q19/00 ,  A61Q19/08 ,  C07F9/30 ,  A61K31/662 ,  C07F9/572 ,  A61K31/675 ,  C07C53/18

CPC classification number: C07F9/655354 ,  A61K8/55 ,  A61K8/64 ,  A61K31/662 ,  A61K31/67 ,  A61K31/675 ,  A61Q19/00 ,  A61Q19/08 ,  C07C53/18 ,  C07F9/306 ,  C07F9/5728

Abstract: This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease-12 (MMP-12), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP-12. Formula (I).

公开(公告)号：US20180208576A1

公开(公告)日：2018-07-26

申请号：US15745754

申请日：2016-07-07

Applicant: DSM IP ASSETS B.V.

Inventor： Stéphanie BOUDON ,  Piero GEOTTI-BIANCHINI ,  Marc HEIDL ,  Eileen JACKSON ,  Alexander SCHLIFKE-POSCHALKO

IPC: C07D401/10 ,  C07D265/30 ,  C07D223/04 ,  C07D211/16 ,  A61K8/49 ,  A61Q19/08

CPC classification number: C07D401/10 ,  A61K8/49 ,  A61K8/4906 ,  A61K8/4926 ,  A61Q19/08 ,  C07D211/16 ,  C07D223/04 ,  C07D265/30

Abstract: The present invention relates to novel selective 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors and the use thereof to prevent age-induced skin structure and function defects.