公开(公告)号：US20200239925A1

公开(公告)日：2020-07-30

申请号：US16648879

申请日：2018-09-25

Applicant: DSM IP ASSETS B.V.

Inventor： Nathalie BALCH ,  Paul BLOMQUIST ,  Reed DOTEN ,  Peter HOUSTON ,  Ethan LAM ,  Jenna MCMAHON ,  Joshua TRUEHEART ,  Celine VIAROUGE ,  René Marcel DE JONG

IPC: C12P23/00

Abstract: The present invention is related to production of retinyl esters, such as in particular retinyl acetate, an important building block for production of vitamin A. The retinyl esters might be generated via enzymatic conversion of retinol which process includes the use of enzymes with acetyl-transferase (ATF) activity, thus acetylating retinol into retinol/retinyl acetate. Said process is particularly useful for biotechnological production of vitamin A.

公开(公告)号：US20190010508A1

公开(公告)日：2019-01-10

申请号：US16068395

申请日：2017-01-06

Applicant: Adam G. LAWRENCE ,  Peter Louis HOUSTON ,  Jessica Leigh MCGRATH ,  Joshua TRUEHEART ,  DSM IP Assets B.V.

Inventor： Adam G. LAWRENCE ,  Peter Louis HOUSTON ,  Jessica Leigh MCGRATH ,  Joshua TRUEHEART

IPC: C12N15/81 ,  C12N1/16 ,  C12N15/10

Abstract: The present invention is directed to a process for switching the mating type of a Yarrowia fungus strain into an opposite mating type, and to the use thereof to sexually cross two individual strains resulting in new strains.

公开(公告)号：US20160186128A1

公开(公告)日：2016-06-30

申请号：US14772137

申请日：2014-03-13

Applicant: DSM IP ASSETS B.V.

Inventor： Joshua TRUEHEART ,  Jessica Leigh

IPC: C12N1/08 ,  C12P23/00 ,  C12N9/22

CPC classification number: C12N1/08 ,  C12N9/22 ,  C12P23/00 ,  C12Y301/21004

Abstract: The present invention relates to the use of a thermophilic nuclease for degrading nucleic acids in vivo and/or in situ, wherein the thermophilic nuclease is heterologous to the host cell and is produced by the host rather than being added exogenously. The present invention further relates to a genetically modified cell which was produced according to the above method. The present invention is particularly beneficial in inactivating the biological activity of recombinant DNA in biomass or biomass-derived products.

Abstract translation: 本发明涉及嗜热核酸酶在体内和/或原位降解核酸的用途，其中嗜热核酸酶与宿主细胞是异源的，并且由宿主产生，而不是外源性加入。 本发明还涉及根据上述方法生产的遗传修饰细胞。 本发明特别有益于在生物质或生物质衍生产品中灭活重组DNA的生物学活性。