-
1.发明授权Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor 失效酵母细胞工程化生产信息素系统蛋白质代理，并用于此公开(公告)号：US07416881B1
公开(公告)日：2008-08-26
申请号：US09286166
申请日：1999-04-05
Applicant: Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
Inventor： Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
CPC classification number: C12N15/81 , C07K14/395 , C07K2319/02
Abstract: Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
Abstract translation: 酵母细胞被设计成表达信息素系统蛋白质的替代物（例如，参与α因子成熟的酶，α-因子的转运蛋白，信息素受体等）和代理的潜在的肽调节剂，在这样的 替代物的抑制或活化影响酵母细胞的可筛选或选择性状的方式。 各种附加功能提高了筛选/选择系统的信噪比。
-
公开(公告)号：US07105309B2
公开(公告)日：2006-09-12
申请号：US10263341
申请日：2002-10-01
Applicant: Dana M. Fowlkes , James R. Broach , John P. Manfredi , Christine A. Klein , Andrew J. M. Murphy , Jeremy I. Paul , Joshua Trueheart
Inventor： Dana M. Fowlkes , James R. Broach , John P. Manfredi , Christine A. Klein , Andrew J. M. Murphy , Jeremy I. Paul , Joshua Trueheart
IPC: G01N33/567
CPC classification number: C12N15/81 , C07K14/395 , C07K2319/02
Abstract: Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
-
公开(公告)号：US6159705A
公开(公告)日：2000-12-12
申请号：US936632
申请日：1997-09-24
Applicant: Joshua Trueheart , Jeremy I. Paul , Hans A. Fuernkranz , Debra Nathan , Scott Holmes
Inventor： Joshua Trueheart , Jeremy I. Paul , Hans A. Fuernkranz , Debra Nathan , Scott Holmes
IPC: C12N15/00 , C07K14/39 , C07K19/00 , C12N1/16 , C12N1/19 , C12N15/09 , C12N15/81 , C12Q1/00 , C12Q1/02 , C12Q1/37 , C12Q1/42 , C12Q1/48 , C12Q1/68
CPC classification number: C12Q1/025 , C07K14/39 , C12N15/81 , C12Q1/6897
Abstract: The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. The subject assay is particularly amenable for identifying surrogate ligands for receptors especially from small molecule or peptide libraries or from peptides produced by an autocrine system.
Abstract translation: 本发明提供用于筛选和鉴定与细胞蛋白质例如受体或离子通道特异性相互作用并调节其活性的药学有效化合物的快速有效的测定。 本发明分析使得能够快速筛选大量的化合物以鉴定那些充当细胞蛋白的生物活性的激动剂或拮抗剂的化合物。 主题测定特别适用于鉴定受体的替代配体，特别是从小分子或肽文库或由自分泌系统产生的肽。
-
公开(公告)号：US20110039327A1
公开(公告)日：2011-02-17
申请号：US12600559
申请日：2008-05-19
Applicant: Aaron Adriaan Winkler , Abraham Frederik De Hulster , Johannes Pieter Van Dijken , Jacobus Thomas Pronk , Joshua Trueheart , Kevin T. Madden , Carlos Gancedo Rodriguez , Carmen-Lisset Flores Mauriz , Antonius Jeroen Adriaan Van Maris , Jacob C. Harrison
Inventor： Aaron Adriaan Winkler , Abraham Frederik De Hulster , Johannes Pieter Van Dijken , Jacobus Thomas Pronk , Joshua Trueheart , Kevin T. Madden , Carlos Gancedo Rodriguez , Carmen-Lisset Flores Mauriz , Antonius Jeroen Adriaan Van Maris , Jacob C. Harrison
IPC: C12N1/18
Abstract: Improved systems for the biological production of organic acids are described.
Abstract translation: 描述了用于生物制备有机酸的改进的系统。
-
5.发明授权Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor 失效酵母细胞工程化生产信息素系统蛋白质代理，并用于此公开(公告)号：US07611854B2
公开(公告)日：2009-11-03
申请号：US10600003
申请日：2003-06-18
Applicant: Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
Inventor： Dana M. Fowlkes , Jim Broach , John Manfredi , Christine Klein , Andrew J. Murphy , Jeremy Paul , Joshua Trueheart
CPC classification number: C12N15/81 , C07K14/395 , C07K2319/02
Abstract: Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that the inhibition or activation of the surrogate affects a screenable or selectable trait of the yeast cells. Various additional features improve the signal-to-noise ratio of the screening/selection system.
Abstract translation: 酵母细胞被设计成表达信息素系统蛋白质的替代物（例如，参与α因子成熟的酶，α-因子的转运蛋白，信息素受体等）和代理的潜在的肽调节剂，在这样的 替代物的抑制或活化影响酵母细胞的可筛选或选择性状的方式。 各种附加功能提高了筛选/选择系统的信噪比。
-
Patent Agency Ranking
公开(公告)号：US20050255568A1
公开(公告)日：2005-11-17
申请号：US10858730
申请日：2004-06-01
Applicant: Richard Bailey , Paul Blomquist , Reed Doten , Edward Driggers , Kevin Madden , Jessica O'Leary , George O'Toole , Joshua Trueheart , Michael Walbridge , Peter Yorgey
Inventor： Richard Bailey , Paul Blomquist , Reed Doten , Edward Driggers , Kevin Madden , Jessica O'Leary , George O'Toole , Joshua Trueheart , Michael Walbridge , Peter Yorgey
IPC: C12N1/21 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/12 , C12N9/88 , C12P13/04 , C12P13/08 , C12P13/12
CPC classification number: C12N9/0008 , C12N9/0006 , C12N9/1007 , C12N9/1029 , C12N9/1085 , C12N9/1217 , C12N9/88 , C12P13/04 , C12P13/08 , C12P13/12
Abstract: Methods and compositions for amino acid production using genetically modified bacteria are disclosed.
Abstract translation: 公开了使用转基因细菌进行氨基酸生产的方法和组合物。
-
公开(公告)号：US20050059135A1
公开(公告)日：2005-03-17
申请号：US10752478
申请日：2004-01-05
Applicant: Christine Klein , Andrew Murphy , Dana Fowlkes , James Broach , John Manfredi , Jeremy Paul , Joshua Trueheart
Inventor： Christine Klein , Andrew Murphy , Dana Fowlkes , James Broach , John Manfredi , Jeremy Paul , Joshua Trueheart
IPC: C07K14/395 , C12N5/02 , C12N15/81 , C07H21/04 , C07K14/705 , C12N1/18
CPC classification number: C12N15/81 , C07K14/395 , C07K2319/02
Abstract: The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screening of large numbers of polypeptides in a library to identifying those polypeptides which induce or antagonize receptor bioactivity. The subject assay is particularly amenable for identifying surrogate ligands for orphan receptors.
Abstract translation: 本发明提供用于筛选和鉴定与细胞受体或离子通道的活性特异性相互作用并调节其活性的药学有效化合物的快速有效的测定。 本发明分析使得能够快速筛选文库中的大量多肽以鉴定诱导或拮抗受体生物活性的那些多肽。 主题测定特别适用于鉴定孤儿受体的替代配体。
-
公开(公告)号：US09909130B2
公开(公告)日：2018-03-06
申请号：US13586611
申请日：2012-08-15
Applicant: Richard B. Bailey , Kevin T. Madden , Joshua Trueheart
Inventor： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart
Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
-
公开(公告)号：US08633009B2
公开(公告)日：2014-01-21
申请号：US12293237
申请日：2007-03-20
Applicant: Richard B. Bailey , Kevin T. Madden , Joshua Trueheart
Inventor： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart
CPC classification number: C12N15/815 , C12N15/52 , C12N15/81 , C12P7/6463 , C12P7/6481 , C12P7/66
Abstract: The present invention provides systems for producing engineered oleaginous yeast or fungi that express quinone derived compounds.
Abstract translation: 本发明提供用于生产表达醌衍生化合物的工程化含油酵母或真菌的系统。
-
公开(公告)号：US20120149886A1
公开(公告)日：2012-06-14
申请号：US12937204
申请日：2009-04-10
Applicant: Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
Inventor： Richard B. Bailey , Kevin T. Madden , Joshua Trueheart , Reed Doten , Maria Mayorga , Joshua Griffin Dunn , Dan Dueppen
IPC: C07H15/10 , C12P17/02 , C12P19/02 , C12P7/26 , C12P7/22 , C12P5/00 , C12P5/02 , C12N1/15 , C12N1/19 , C07D405/06 , C07D303/12 , C07C49/653 , C07C35/00 , C07C11/02 , C07C13/28 , C12P17/04
CPC classification number: C12P23/00 , A23K20/158 , A23K20/174 , A23K20/179 , A23K50/80 , C12N9/00 , C12N15/52 , C12P7/6463 , Y02A40/818 , Y02E50/343
Abstract: The present disclosure provides systems for producing engineered oleaginous yeast or fungi that express carotenoids.
Abstract translation: 本公开提供了用于生产表达类胡萝卜素的工程化含油酵母或真菌的系统。
-
-
-
-
-
-
-
-
-
Search Results
45
records
(took 0.033 seconds)
