公开(公告)号：US20180344776A1

公开(公告)日：2018-12-06

申请号：US15997422

申请日：2018-06-04

Applicant: Duke University

Inventor： Victor J. Dzau ,  Maria Mirotsou ,  Tilanthi Jayawardena

IPC: A61K35/33 ,  C12N5/077 ,  A61L27/38 ,  C12N15/113 ,  A61L31/16 ,  A61L29/16 ,  A61L27/54

Abstract: A method for promoting conversion of cells into cardiomyocytic tissue is carried out by contacting fibrotic tissue (e.g., scar tissue) with a microRNA oligonucleotide or combination of microRNA oligonucleotides. The methods lead to direct reprogramming of fibroblasts to cardiomyocytes or cardiomyoblasts.

公开(公告)号：US20140357703A1

公开(公告)日：2014-12-04

申请号：US14256169

申请日：2014-04-18

Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  Duke University

Inventor： Victor J. Dzau ,  Maria Mirotsou

IPC: C07K14/475 ,  C07K14/435

CPC classification number: A61K38/1709 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0085 ,  A61K38/17 ,  A61K38/18 ,  A61K45/06 ,  C07K14/435 ,  C07K14/475 ,  C12N5/10 ,  C12N15/09 ,  C12N15/63

Abstract: A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic conditions.

Abstract translation: 间充质干细胞（如分泌型卷曲相关蛋白（Sfrp））的纯化旁分泌因子可用于减少与缺血性疾病相关的细胞死亡或组织损伤。