摘要:
The present invention generally relates to a method for an improved treatment for Alzheimer's disease (AD) using immunotherapy, e.g., immunotherapy targeting β amyloid (Aβ), e.g., immunotherapy based on AN1792. In one embodiment, the method allows for predicting an adverse clinical response, and therefore allows for an improved safety profile of AN1792. In another embodiment, the method allows for predicting a favorable clinical response, and therefore allows for an improved efficacy profile of AN1792. The methods of the present invention may be combined to predict a favorable clinical response and the lack of an adverse clinical response.
摘要:
A foldable multi-purpose tool includes a pair of jaws and a pair of folding handles and is capable of accepting removable cartridges. In the extended position, the handles operate the jaws. Each removable cartridge contains a number of relatively small tool blades that are preferably selected by functional categories. Various cartridge hold-down and removal mechanisms are also provided.
摘要:
Application developers can request to have their applications registered for use with a content delivery platform. The operator of the content delivery platform establishes perimeters defining geographic areas, and maintains records reserving particular areas for delivery of content associated with particular sponsors. Registered applications running on mobile devices can request content from the content delivery platform. Based at least in part on the request, the content delivery platform can identify a target location, which may be the location of the mobile device, or some other location indicated in the request. A mobile device can be provided content based on the relationship of the target location to the geographic areas, so that a registered application running on a mobile device with a target location contained within a geographic area assigned to a particular sponsor will receive content related to that sponsor.
摘要:
Application developers can request to have their applications registered for use with a content delivery platform. The operator of the content delivery platform establishes perimeters defining geographic areas, and maintains records reserving particular areas for delivery of content associated with particular sponsors. Registered applications running on mobile devices can request content from the content delivery platform. Based at least in part on the request, the content delivery platform can identify a target location, which may be the location of the mobile device, or some other location indicated in the request. A mobile device can be provided content based on the relationship of the target location to the geographic areas, so that a registered application running on a mobile device with a target location contained within a geographic area assigned to a particular sponsor will receive content related to that sponsor.
摘要:
A method assigns token requirements to service subscriptions in a service platform, such as a service platform containing entities or a database containing a plurality of said entities. The operator of the service platform establishes customization factors and maintains records reserving data services associated with token requirements for delivery to entities. In addition, customization factors are determined from values representing information associated with objects in a database. Token requirements associated with data services are calculated from one or more formulas utilizing customization factors. Sponsorships associated with the entities can be accepted by the service platform. The service platform can apply credit toward the fulfillment of token requirements. An entity can be provided a data service based on a relationship with a sponsorship such that an entity assigned a subscription having a token requirement fulfilled as a result of applying credit from a sponsorship will receive services related to the subscription.
摘要:
A shock detector system for determining the existence of a harmful electrical condition in a body of water proximate a first shock detector or a second shock detector with the first shock detector providing a danger signal if the harmful electrical condition proximate the first shock detector could injure or kill a person coming into contact with the body of water proximate the first shock detector and the second shock detector providing a caution signal if there is no harmful electrical condition detected by the second shock detector even though there is a harmful electrical condition proximate the first shock detector.
摘要:
The invention relates to razors and razor blade cartridges and methods of manufacture therefore including at least one razor blade housing made from polymer material and at least one skin contacting surface, the at least one skin contacting surface being made of a superhydrophillic polymer material. The polymer material has surface properties modified by functionalisation. Preferably the polymer material is a TPU or TPE, with a Rockwell hardness D scale between 30 D and 85 D, a tensile strength between 35 and 80 MPA and a flexural modulas between 40 and 2350 MPA The invention also relates to a method of manufacture of a razor blade cartridge including the steps of moulding a cartridge housing including skin contacting surfaces of polymeric material; subsequently activating the skin engaging surfaces of the polymer using either physical or chemical means to make the surface receptive to the covalent grafting of a monomer, and grafting a functional group onto the surface such as an N-vinyl lactam.
摘要:
Embodiments related to dual mode rotatable input devices that permit both resistive and non-resistive rotation are disclosed. One embodiment comprises a stationary hub, a rotatable member rotatable around the stationary hub, and a resistive rotation mechanism forming an interface between the stationary hub and the rotatable member. The resistive rotation mechanism comprises a resistive surface and a movable interface member configured to selectively contact the resistive surface, wherein the resistive surface and the movable interface member move relative to one another with rotation of the rotatable member. The resistive mechanism further comprises a biasing mechanism that urges the movable interface member into engagement with the resistive surface when a rotational velocity of the rotatable member is below a threshold velocity, and allows separation of the interface member and the resistive surface when the rotational velocity of the rotatable member is above the threshold velocity.
摘要:
A method of making an article comprises a heat cured composition with at least one foil or sheet applied on one face of the cured composition. The article may be an electrode. The composition may comprise titanium suboxide.
摘要:
The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating type I diabetes. A variety of markers are provided, wherein changes in the levels of expression of one or more of the markers is correlated with the presence of type I diabetes.