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公开(公告)号：US07998497B2
公开(公告)日：2011-08-16
申请号：US11695545
申请日：2007-04-02
申请人： Eugene de Juan, Jr. , Stephen Boyd , Cary Reich , Alan Rapacki , Hanson S. Gifford, III , Mark Deem
发明人： Eugene de Juan, Jr. , Stephen Boyd , Cary Reich , Alan Rapacki , Hanson S. Gifford, III , Mark Deem
IPC分类号： A61F2/02
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/0026 , A61F9/00772 , A61F9/00781 , A61F2220/0008 , A61F2250/0067 , A61F2250/0087 , A61K9/00 , A61K9/0017 , A61K9/06 , A61K31/215 , A61K31/216 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/573 , A61K47/34 , A61L31/16
摘要： Implant devices, systems and methods for insertion into a punctum of a patient optionally comprises a drug core and a sheath body disposed over the drug core. The drug core includes a therapeutic agent deliverable into the eye, and the sheath defines at least one exposed surface of the drug core. The exposed surface(s) of the drug core may contact a tear or tear film fluid and release the therapeutic agent at therapeutic levels over a sustained period when the implant is implanted for use. The implant may include a retention element to retain the drug core and sheath body near the punctum, optionally comprising a shape memory alloy that can resiliently expand. An occlusive element may be attached to the retention element to at least partially occlude tear flow through the canalicular lumen.
摘要翻译： 用于插入患者泪点的植入装置，系统和方法可任选地包括药物核心和设置在药物核心上方的鞘体。 药物核心包括可递送到眼睛中的治疗剂，护套限定药物核心的至少一个暴露表面。 药物核心的暴露表面可以接触泪液或泪膜流体，并且当植入物植入使用时在持续的时间内以治疗水平释放治疗剂。 植入物可以包括保持元件，以将药物核心和鞘体保持在泪点附近，任选地包括可弹性膨胀的形状记忆合金。 闭塞元件可以连接到保持元件以至少部分地封闭穿过小管腔的泪液流动。
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公开(公告)号：US20050145253A1
公开(公告)日：2005-07-07
申请号：US11071850
申请日：2005-03-02
申请人： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
发明人： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
IPC分类号： A61B17/00 , A61B17/24 , A61F2/04 , A61F2/06 , A61F2/24 , A61M16/00 , A61M16/20 , A61M11/00 , A62B9/06
CPC分类号： A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要： Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway. A region of the lung is aspirated distal of the flow control device while the patient is inhaling.
摘要翻译： 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动。 当患者正在吸入时，肺部的区域被吸入流量控制装置的远端。
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公开(公告)号：US20050051163A1
公开(公告)日：2005-03-10
申请号：US10703919
申请日：2003-11-06
申请人： Mark Deem , Bernard Andreas , Sunmi Chew , Antony Fields , Ronald French , Hanson Gifford , Ronald Hundermark , Alan Rapacki , Douglas Sutton , Peter Wilson
发明人： Mark Deem , Bernard Andreas , Sunmi Chew , Antony Fields , Ronald French , Hanson Gifford , Ronald Hundermark , Alan Rapacki , Douglas Sutton , Peter Wilson
CPC分类号： A61F2/24 , A61B17/12104 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0067 , A61F2230/0091 , F16K15/147
摘要： An implantable flow control element is provided which prevents air from entering an isolated portion of a patient's lung. The element may permit air to escape from the isolated portion so that the element acts like a valve. Systems for implanting pulmonary devices are also provided.
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公开(公告)号：US08747884B2
公开(公告)日：2014-06-10
申请号：US13184690
申请日：2011-07-18
申请人： Eugene De Juan, Jr. , Stephen Boyd , Cary Reich , Alan Rapacki , Hanson S. Gifford , Mark Deem
发明人： Eugene De Juan, Jr. , Stephen Boyd , Cary Reich , Alan Rapacki , Hanson S. Gifford , Mark Deem
CPC分类号： A61K9/0051 , A61F9/0017 , A61F9/0026 , A61F9/00772 , A61F9/00781 , A61F2220/0008 , A61F2250/0067 , A61F2250/0087 , A61K9/00 , A61K9/0017 , A61K9/06 , A61K31/215 , A61K31/216 , A61K31/55 , A61K31/557 , A61K31/5575 , A61K31/573 , A61K47/34 , A61L31/16
摘要： An implant for insertion through a punctum and into a canalicular lumen of a patient. The implant includes a matrix of material, a therapeutic agent dispersed in the matrix of material, a sheath disposed over a portion of the matrix of material and configured to inhibit the therapeutic agent from being released from the matrix of material into the canalicular lumen and to allow the therapeutic agent to be released from a surface of the matrix of material to a tear film, and a retention structure configured to retain the implant within the canalicular lumen.
摘要翻译： 用于插入通过泪点并进入患者的小管腔的植入物。 植入物包括材料基质，分散在材料基质中的治疗剂，鞘层，其设置在材料基质的一部分上并且被配置为抑制治疗剂从材料基质释放到小管腔内，并且 允许治疗剂从材料基质的表面释放到泪膜，以及构造成将植入物保持在小管腔内的保留结构。
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公开(公告)号：US07011094B2
公开(公告)日：2006-03-14
申请号：US10627517
申请日：2003-07-25
申请人： Alan Rapacki , Michael Barrett
发明人： Alan Rapacki , Michael Barrett
CPC分类号： A61F2/04 , A61B17/12022 , A61B17/12036 , A61B17/1204 , A61B17/12104 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/12054 , A61B2090/061 , A61F2/06 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2220/0041 , A61F2230/005 , A61F2230/0054 , A61F2230/0067 , A61F2230/0076 , A61F2230/0078 , A61F2230/0093 , F16K15/147 , Y10S128/912
摘要： A flow control device includes a sealing component that can be positioned within a bronchial lumen. The sealing component can comprise two or more overlapping segments that are movable relative to one another such that the segments collectively form a seal that can expand and contract in size to fit within and seal bronchial lumens of various sizes.
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公开(公告)号：US20060020347A1
公开(公告)日：2006-01-26
申请号：US11075633
申请日：2005-03-08
申请人： Michael Barrett , Michael Hendricksen , Alan Rapacki , Ronald Hundertmark , Jeffrey Dolin , Robert George , John McCutcheon , Antony Fields
发明人： Michael Barrett , Michael Hendricksen , Alan Rapacki , Ronald Hundertmark , Jeffrey Dolin , Robert George , John McCutcheon , Antony Fields
IPC分类号： A61F2/04
CPC分类号： A61B17/12104 , A61B17/12022 , A61B17/12172 , A61F2/24 , A61F2/2412 , A61F2/2418 , A61F2/86 , A61F2/91 , A61F2002/043 , A61F2230/0054
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region.
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公开(公告)号：US20050166925A1
公开(公告)日：2005-08-04
申请号：US11092123
申请日：2005-03-28
申请人： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
发明人： Peter Wilson , Antony Fields , Hanson Gifford , John McCutcheon , Michael Hendricksen , Alan Rapacki , David Tholfsen , Michael Barrett , Ronald Hundertmark , Douglas Sutton
CPC分类号： A61F2/2412 , A61B2017/1205 , A61F2/04 , A61F2/06 , A61F2/2418 , A61F2/2427 , A61F2/91 , A61F2002/043 , A61F2002/9522 , Y10S128/912
摘要： Methods and systems for lung volume reduction of a patient are described. The methods include implanting a flow control device in a bronchial passageway of the lung. The flow control device regulates fluid flow through the bronchial passageway and includes a valve protector that at least partially surrounds a valve member. The valve protector has sufficient rigidity to maintain the shape of the valve member against compression.
摘要翻译： 描述了患者肺容积减少的方法和系统。 所述方法包括在肺的支气管通道中植入流量控制装置。 流量控制装置调节通过支气管通道的流体流动并且包括至少部分地围绕阀构件的阀保护器。 阀保护器具有足够的刚性以保持阀构件的形状不被压缩。
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