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    Detector for radiation, particularly high energy electromagnetic radiation
    19.
    发明授权
    Detector for radiation, particularly high energy electromagnetic radiation 有权
    辐射检测器，特别是高能量电磁辐射

    公开(公告)号：US09594171B2

    公开(公告)日：2017-03-14

    申请号：US14403707

    申请日：2012-06-08

    申请人： Irina Astafieva ,  Oliver Heid ,  Timothy Hughes

    发明人： Irina Astafieva ,  Oliver Heid ,  Timothy Hughes

    IPC分类号： G01V5/04 ,  G01T1/185 ,  H01J47/02 ,  G01T1/20

    CPC分类号： G01T1/185 ,  G01T1/2006 ,  H01J47/02 ,  H01J47/024

    摘要： A detector for radiation, particularly high energy electromagnetic radiation is provided. The detector includes a converting section including a cathode for converting the radiation incident on the converting section in electrons by the photoelectric effect. The detector further includes a gas electron multiplier for generating an electron avalanche from electrons which are generated by the converting section and enter the gas electron multiplier, the gas electron multiplier including a first electrode, a dielectric layer and a second electrode, the first electrode being disposed at a first side of the dielectric layer adjacent to the converting section and the second electrode being disposed at a second side of the dielectric layer opposite to the first side. The gas electron multiplier includes a number of holes filled with gas, the holes extending through the first electrode, the dielectric layer and the second electrode.

    摘要翻译： 提供了用于辐射的检测器，特别是高能量的电磁辐射。 检测器包括转换部分，其包括用于通过光电效应将入射在转换部分上的辐射转换为电子的阴极。 检测器还包括气体电子倍增器，用于从由转换部分产生并进入气体电子倍增器的电子产生电子雪崩，气体电子倍增器包括第一电极，电介质层和第二电极，第一电极为 设置在与转换部相邻的电介质层的第一侧，第二电极设置在与第一侧相反的电介质层的第二侧。 气体电子倍增器包括填充有气体的多个孔，所述孔延伸穿过第一电极，电介质层和第二电极。

    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT
    20.
    发明申请
    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
    APO A-I MIME技术和治疗方法

    公开(公告)号：US20110263497A1

    公开(公告)日：2011-10-27

    申请号：US13177473

    申请日：2011-07-06

    申请人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    发明人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    IPC分类号： A61K38/10 ,  A61P9/10

    CPC分类号： A61K38/17 ,  A61K31/661 ,  A61K38/10 ,  A61K38/1709

    摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.

    摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。