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    Antifouling heparin coatings
    4.
    发明申请
    Antifouling heparin coatings 有权
    防污肝素涂层

    公开(公告)号：US20050266038A1

    公开(公告)日：2005-12-01

    申请号：US10857141

    申请日：2004-05-27

    申请人： Thierry Glauser ,  Eugene Michal ,  Charles Claude ,  Stephen Pacetti

    发明人： Thierry Glauser ,  Eugene Michal ,  Charles Claude ,  Stephen Pacetti

    IPC分类号： A61L31/10 ,  A61L31/16 ,  A61L33/00 ,  C08L1/00 ,  C08L33/10 ,  C08L33/14 ,  A61F2/06

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  C08L1/00 ,  C08L33/14 ,  C08L2666/26

    摘要： A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。

    Antifouling heparin coatings
    7.
    发明授权
    Antifouling heparin coatings 有权
    防污肝素涂层

    公开(公告)号：US09561309B2

    公开(公告)日：2017-02-07

    申请号：US10857141

    申请日：2004-05-27

    申请人： Thierry Glauser ,  Eugene Michal ,  Charles Claude ,  Stephen D. Pacetti

    发明人： Thierry Glauser ,  Eugene Michal ,  Charles Claude ,  Stephen D. Pacetti

    IPC分类号： A61L31/10 ,  C08L33/14 ,  A61L31/16 ,  C08L1/00

    CPC分类号： A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2300/42 ,  C08L1/00 ,  C08L33/14 ,  C08L2666/26

    摘要： A medical device comprising a coating thereon comprising a biocompatible polymer and heparin is provided herein. Heparin is coupled with the biocompatible polymer via a spacer having a grouping that renders a binding site of the heparin molecule accessible by a binding protein. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

    摘要翻译： 本文提供了包括其上的包含生物相容性聚合物和肝素的医疗装置。 肝素通过具有使得肝素分子的结合位点可被结合蛋白使得的分组的间隔物与生物相容性聚合物偶联。 医疗器械可以植入人类用于治疗动脉粥样硬化，血栓形成，再狭窄，出血，血管解剖或穿孔，血管动脉瘤，易损斑块，慢性完全闭塞，跛行，静脉和人造移植物的吻合增殖等疾病 ，胆管阻塞，输尿管阻塞，肿瘤阻塞或其组合。