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公开(公告)号:US07144077B2
公开(公告)日:2006-12-05
申请号:US11043834
申请日:2005-01-26
申请人: Rainer Grimm , Thomas Becher , Richard Wagner
发明人: Rainer Grimm , Thomas Becher , Richard Wagner
CPC分类号: B60J7/024
摘要: A mechanism for a sun roof has at least one guide rail, a lifting slide that can be moved along the guide rail, and a guide slide that can be locked in the guide rail in an initial position. The guide slide can be moved in the guide rail once the guide slide is unlocked. A cover holder is coupled to the lifting slide and the guide slide in such a way that the cover can be moved between a closed position and an opened position.
摘要翻译: 用于太阳屋顶的机构具有至少一个导轨,可沿着导轨移动的升降滑块和可在初始位置被锁定在导轨中的导向滑块。 一旦导向滑块解锁,导轨滑块就可以在导轨上移动。 盖保持器以使得盖可以在关闭位置和打开位置之间移动的方式联接到提升滑块和引导滑动件。
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公开(公告)号:US20060149521A1
公开(公告)日:2006-07-06
申请号:US11274682
申请日:2005-11-14
申请人: John Baxter , Beatrice Darimont , Weijun Feng , Robert Fletterick , Peter Kushner , Richard Wagner , Brian West , Keith Yamamoto
发明人: John Baxter , Beatrice Darimont , Weijun Feng , Robert Fletterick , Peter Kushner , Richard Wagner , Brian West , Keith Yamamoto
CPC分类号: G01N33/6875 , G01N2500/20 , H01L21/3065 , H01L21/314 , H01L29/6659
摘要: The present invention comprises cocrystal of a nuclear receptor comprising a molecule bound to the coactivator binding site of said nuclear receptor. The present invention further comprises a machine-readable data storage medium encoded with machine readable data corresponding to the structure coordinates of amino acids of a nuclear receptor coactivator binding site which, when using a machine programmed with instructions for using said data, is capable of displaying a graphical three-dimensional representation of a molecular complex of a compound bound to a nuclear receptor coactivator binding site.
摘要翻译: 本发明包括核受体的共晶体,其包含与所述核受体的共激活因子结合位点结合的分子。 本发明还包括一种机器可读数据存储介质,其被编码有对应于核受体共激活剂结合位点的氨基酸的结构坐标的机读数据,当使用编程有用于使用所述数据的指令的机器时,能够显示 与核受体共激活子结合位点结合的化合物的分子复合物的图形三维表示。
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公开(公告)号:US5503798A
公开(公告)日:1996-04-02
申请号:US228684
申请日:1994-04-18
IPC分类号: C22C14/00
CPC分类号: C22C14/00 , F05C2201/021 , F05C2201/043
摘要: A multiphase, high-temperature material contains an intermetallic base alloy of the Ti.sub.3 Al type, which is intended especially for use in heat engines such as internal combustion engines, gas turbines and aircraft engines. The material contains from 44 to 73 atom % titanium, from 19 to 35 atom % aluminum, from 2 to 6 atom % silicon, and from 5 to 15 atom % niobium. The desired microstructure is attained by heat treating the alloy at between 800.degree. and 1100.degree. C.
摘要翻译: 多相高温材料含有Ti3Al型金属间基体合金,其特别用于内燃机,燃气轮机和飞机发动机等发动机。 该材料含有44至73原子%的钛,19至35原子%的铝,2至6原子%的硅和5至15原子%的铌。 所需的微观结构是通过在800〜1100℃之间热处理合金而实现的。
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公开(公告)号:US5117868A
公开(公告)日:1992-06-02
申请号:US441000
申请日:1989-11-22
申请人: Richard Wagner
发明人: Richard Wagner
CPC分类号: F15B20/00 , B64C13/40 , F16K31/42 , Y10T137/86582 , Y10T137/86614
摘要: Pilot-controlled directional valve having two positions, an admitting position and a closing position for a hydraulic user device, such closing position can be obtained independently from the presence of a supplied hydraulic pressure.
摘要翻译: 具有两个位置的先导控制换向阀,用于液压用户装置的允许位置和关闭位置,这种关闭位置可以独立于所提供的液压的存在而获得。
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公开(公告)号:US08598089B2
公开(公告)日:2013-12-03
申请号:US13040674
申请日:2011-03-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
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公开(公告)号:US08410028B2
公开(公告)日:2013-04-02
申请号:US13051314
申请日:2011-03-18
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffan Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C12N15/1068 , C07H21/00 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
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公开(公告)号:US20120245040A1
公开(公告)日:2012-09-27
申请号:US13040674
申请日:2011-03-04
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供合成包含编码寡核苷酸标签的分子文库的方法。
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公开(公告)号:US07972992B2
公开(公告)日:2011-07-05
申请号:US11015458
申请日:2004-12-17
申请人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
发明人: Barry Morgan , Stephen Hale , Christopher C. Arico-Muendel , Matthew Clark , Richard Wagner , David I. Israel , Malcolm L. Gefter , Dennis Benjamin , Nils Jakob Vest Hansen , Malcolm J. Kavarana , Steffen Phillip Creaser , George J. Franklin , Paolo A. Centrella , Raksha A. Acharya
IPC分类号: C40B50/00
CPC分类号: C07H21/00 , C12N15/1068 , C40B50/10
摘要: The present invention provides methods of synthesizing a molecule comprising a functional moiety which is operatively linked to an encoding oligonucleotide. The methods include providing an initiator compound comprising an initial functional moiety comprising n building blocks, wherein the initial functional moiety comprises at least one reactive group, and is operatively linked to an initial oligonucleotide; reacting the initiator compound with a building block comprising at least one complementary reactive group, under conditions suitable for reaction of the complementary reactive group to form a covalent bond; and reacting the initial oligonucleotide with an incoming oligonucleotide corresponding to the building block in the presence of an enzyme which catalyzes ligation of the initial oligonucleotide and the incoming oligonucleotide, under conditions suitable for ligation of the incoming oligonucleotide and the initial oligonucleotide to form an encoding oligonucleotide.
摘要翻译: 本发明提供合成包含与编码寡核苷酸有效连接的功能部分的分子的方法。 所述方法包括提供包含起始功能部分的引发剂化合物,其包含n个结构单元,其中所述初始功能部分包含至少一个反应性基团,并且可操作地连接到初始寡核苷酸; 使引发剂化合物与包含至少一个互补反应性基团的构建块在适于互补反应性基团反应以形成共价键的条件下反应; 并在初始寡核苷酸和入侵寡核苷酸的连接酶存在下,使初始寡核苷酸与对应于构建单元的入侵寡核苷酸反应,在适合连接引入寡核苷酸和初始寡核苷酸的条件下形成编码寡核苷酸 。
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公开(公告)号:US20070042401A1
公开(公告)日:2007-02-22
申请号:US11450938
申请日:2006-06-09
申请人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
发明人: Barry Morgan , Stephen Hale , Christopher Arico-Muendel , Matthew Clark , Richard Wagner , David Israel , Malcolm Gefter , Dennis Benjamin , Nils Hansen , Malcolm Kavarana , Steffen Creaser , George Franklin , Paolo Centrella , Raksha Acharya
CPC分类号: C12N15/1068 , C07H21/00 , C40B50/10
摘要: The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.
摘要翻译: 本发明提供合成包含编码寡核苷酸标签的分子文库的方法。
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公开(公告)号:US20070034957A1
公开(公告)日:2007-02-15
申请号:US11202662
申请日:2005-08-12
申请人: Richard Wagner , D. Hobson Lane
发明人: Richard Wagner , D. Hobson Lane
IPC分类号: H01L23/62
CPC分类号: B62D57/024
摘要: An apparatus in one example has: an electrostatic device having an engagement portion; and an attractive electrostatic force selectively applicable by the electrostatic device to the engagement portion for at least one of holding the electrostatic device or providing locomotion to the electrostatic device.
摘要翻译: 一个实例中的装置具有:具有接合部分的静电装置; 以及由静电装置选择性地应用于接合部分的有吸引力的静电力,用于保持静电装置或向静电装置提供运动中的至少一个。
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