摘要:
The present invention provides a method for identifying a compound of interest by screening libraries of molecules which include an encoding oligonucleotide tag.
摘要:
The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds.
摘要:
A means for simultaneous determination of the radial and angular vectors of rotary motion of a body relative to a single reference axis, by measurement of the common aid differential states of three position detectors and, together with an axial position detector, thus to allow the measurable modulation of magnetic devices such as to provide measurable vector forces to support that body against the vector effects of any external forces that tend to change its position relative to the reference axis, in the absence of any contact between the rotor and the combined system of sensors and magnetic devices. Measurement of the vector forces applied to the suspended b>dC and its resultant vector displacements, provides the functional basis of a device suitable for measuring the effects of mechanical interaction between that body and any spatially constrained sample material in contact with the b>dC, with respect to the applied vector stresses and resultant vector strains that exist as a result of any shearing or grinding abrasion or indentation deformation or cutting action applied by the rotor to that material during a measured time period. The basic device being consistent with the functions of a rotary viscometer or rheometer or appropriate for use in evaluating the action of a drilling or milling cutter, even when the sample material and the b>dC are confined within a chamber subjected to low or high internal pressure with respect to the external environment. Such confinement also avoids volatile loss of constituents from the sample material and any environmental hazard arising from such loss.
摘要:
The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by administering to the subject a therapeutically effective amount of one or more compounds of the invention.
摘要:
The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds.
摘要:
A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH2)n5 where Z is O, N(R12), S, or a bond; Y is CO, CH2, CS, or a bond; R1 is or N(R24R25); and the remaining substituents are as defined in the disclosure.
摘要翻译:用于抑制异戊烯基转移酶活性的咪唑化合物家族。 化合物被下式所覆盖:其中X是(CHR 11)n 3(CH 2)n 4 Z(CH 2)n N 5其中Z是O,N(R 12),S或键; Y是CO,CH 2,CS或键; R 1是或N(R 24,R 25); 并且其余的取代基如本公开中所定义。
摘要:
The present invention relates to compounds which modulate the activity of the S1P1 receptor, the use of these compounds for treating conditions associated with signaling through the S1P1 receptor, and pharmaceutical compositions comprising these compounds.
摘要:
A composition for treating cancer comprising an anti-tumorally effective amount of a product comprising at least one transduction inhibitor of heterotrimeric G protein signals and at least one other anti-cancer agent selected from the group consisting of prenyltransferase inhibitors, taxol and its analogues, gemcitabine and camptothecin and its analogues, administered simultaneously, separately or spread over a period of time and a pharmaceutical carrier.